DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and gcy-32

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	94/378 - (24%)
Similarity:	171/378 - (45%)	Gaps:	66/378 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAK 238
            |||...:|:..|:.:        .::|:..:..|.:|.||...:.|.:..
Worm   360 YVTSINELMQYGMRL--------TAMPLHDATRDLILLNQQRLSDVEVNL--------------- 401

  Fly   239 QKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVS 303
            |..|..|..:::..::.:|.|..:.  :|..:||:.:|.::   |.....||      ..|| .:
Worm   402 QLEANNEQLETMTRELELERQKTDS--ILKDMLPRRIAQQL---LSGEHIEA------CEHE-AT 454

  Fly   304 ILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHA 368
            :::.|:..|.......|.:|:|.||||:|.:.||:.......:::.:.|.|..:||.||..|:||
Worm   455 VMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAVSGIPDYTPEHA 519

  Fly   369 VLCVHMGLSMV-KAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESS 432
            ....|:.|.|: :|...:...:.:|..:|:|||:|.:.||::|....::.::.:.|.||::|||.
Worm   520 ENMCHVALGMMWEARSVIDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGETVTLASQMESL 584

  Fly   433 GKAGRVHISDKTL--AFLNGEFEVEAAFGEKREELLRIAGL-KTYFITKVVKAFASPCAKKINET 494
            |.||::..|....  |...|.||    |..:....::..|| :|||:|:.:|       |.|.|.
Worm   585 GMAGKIQCSKWAYQKAMETGRFE----FSPRGRIDVKQRGLTETYFLTRSLK-------KSIWEI 638

  Fly   495 QAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEE 547
               |.|            |.|.|..:::..|.| :.::.|...|..|:...::
Worm   639 ---IDH------------DRDINVNSIEGYEEL-ETAIENAVTIKSALPRPDQ 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	21/110 (19%)
		CYCc	256..453	CDD:214485	57/199 (29%)
		Guanylate_cyc	294..476	CDD:278633	55/185 (30%)
		CYCc	860..1071	CDD:214485
		Guanylate_cyc	892..1092	CDD:278633
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002
		HNOBA	226..440	CDD:285003	20/104 (19%)
		CYCc	419..608	CDD:214485	59/204 (29%)
		Guanylate_cyc	452..627	CDD:278633	54/179 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810