DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and gcy-33

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	471	Identity:	104/471 - (22%)
Similarity:	205/471 - (43%)	Gaps:	84/471 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   703 IVSESEFNVTASL----ESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYP-SYLSNFGVL 762
            :|.::|.|:|..:    |..::|..:.::..|:.|         :::|...:..| :.|.:....
Worm   280 VVKQTEENITVQINDITEDKVSLEKKTVMDNEYGL---------ESLPYVTLRGPITVLKSSETF 335

  Fly   763 ILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAA 827
            :|:|..|:..|..:.|:.|         |.|.|       .|.|...:.|::|        :..:
Worm   336 LLLATCVVDTLDTMFKMGL---------YLNDF-------GESDCNREIIMAT--------IQKS 376

  Fly   828 LALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDL 892
            ..|.|:..:......|:.:...|::|.|:||       ..|:..::|..||:..|::....|
Worm   377 DTLKTMLENEKRRSEVLTEMTREISEAKKTA-------RTLLTQMMPYEVAQTMMRSGSVDH--- 431

  Fly   893 YSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGS 957
             .:::..|.:.|..:.:||..    ::..:..|.:..||.:.|..|::::.   ..:.|::|||.
Worm   432 -CEAFECVSIGFIRVCDFSKI----SLFIEAFEVVNLLNTIYSHLDSIVDT---HGVYKVETIGE 488

  Fly   958 TYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFN---HFVLKMGINHGP 1019
            :||.::|          .|..:.:. ..::.:..||:...::|...||.:   ..::|.||..||
Worm   489 SYMISAG----------CPYRDDYD-AEMVSDCCLEMVSHIKSFEYQSHDAVKKVLIKCGIFTGP 542

  Fly  1020 ITAGVIGARKPHYDIWGNTVNVASRMESTGKAG-AIQVTEETCNILR---LFGYTFLQRGLVAVK 1080
            :..||:|.|.|.|.::|:|||.||||||:.:.. .||:.:.|.:.:.   ...:....:|.|.||
Worm   543 VVGGVVGVRTPRYCLFGDTVNTASRMESSNQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVK 607

  Fly  1081 GKGQLMTFYLQGKS----QSSAEPVASGVVVLNGQDSSAVESTSELEASDIKMPLLKMNGPEQSL 1141
            |||.:..:.::.|.    ...::|:...:|....:....::..:|...|.   .|.:|:..|
Worm   608 GKGDMRVYEIEKKKGRARYKKSDPLRKKMVAEKKEAEELLDEDNEGHRSS---ALSRMSLGE--- 666

  Fly  1142 EIDQDRSLRNDSAGQE 1157
            .||...|.|...:|.:
Worm   667 SIDSSSSRRGSLSGSQ 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		CYCc	860..1071	CDD:214485	52/217 (24%)
		Guanylate_cyc	892..1092	CDD:278633	53/206 (26%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902
		HNOBA	204..423	CDD:369471	36/182 (20%)
		CYCc	402..598	CDD:214485	56/224 (25%)
		COG5134	<595..744	CDD:227463	20/94 (21%)
		TDA11	<710..>898	CDD:293689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910