Protein Alignment Ac3 and daf-11

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_505960.3
• Gene: daf-11 / 179605
• WormBaseID: WBGene00000907
• Length: 1077
• Species: Caenorhabditis elegans
• Alignment Length: 1082
• Identity: 224/1082 - (20%)
• Similarity: 393/1082 - (36%)
• Gaps: 287/1082 - (26%)

  Fly   251 EVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKK-IYMSRHEN------------- 301
            :|..|:.|:..|.:.     |...:.....||:..:::.|.|: :.:.:.||
 Worm    63 QVGAVLCEECYEGDE-----LASEIYFSTIEDIFENNNIALKETVRIGKRENSVNISDAITIFEP 122

  Fly   302 ---VSILYA-----DIVGF-TAIS-STYSAQDLVKML----NELFARF-----DRLAEKYQQLRI 347
               |.:|:.     |...| ||:| :.|:.::...::    |.|...|     |.:||.:.: .|
 Worm   123 SARVILLFLGNKLNDYTEFMTAMSMNNYTTEEYTPVIVISKNSLELTFPWKENDAIAELFDK-AI 186

  Fly   348 KILGDCY-----------YCISGAPDERPDHAVLCVHM-------GLSMVKAI------KYVQ-Q 387
            .:..:||           |..|..     :..::.:.|       |..:..||      .||| :
 Worm   187 IVYNNCYDKSKISSFLSSYSFSTI-----EETIISLQMYEGYHLLGYYLYTAITNTTLFNYVQPE 246

  Fly   388 KANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDK--TLAFLNG 450
            ||.|  .|.:....|.:.....|||...:||...|..| |........|.:....|  ..|.||.
 Worm   247 KAIS--SMSIPGPFGEIFINSNGQRIAGYDVLVVDKSL-NSNNFIMPLGTISTDKKCPDQACLNF 308

  Fly   451 EFEVEAAF------------GEKREE---LLRIA---GLKTYFITKVVKAFASPCAKKINETQAE 497
            .....::|            ||..::   ::.||   |:...||  ::......|..  ......
 Worm   309 VLNSTSSFEPLKDVPLCGFHGEICDQTGVIIAIAVIMGVLLMFI--IILTTIRKCCN--GSKGRS 369

  Fly   498 IAHP--------------NPNGSTTDIVSDEDDN---------------DATLDDEELLAQNSVS 533
            |::|              |..||....:.....|               .||:|...:||...|.
 Worm   370 ISNPWVIPFQDVRFIDLTNTEGSQHMSIQSLQRNMEEKQRLQSLARTKHIATVDQVYVLADKYVM 434

  Fly   534 NG------------HQIG-----------IAVTADEEEQVKL---ENFKQRLKDELVTRDGHE-N 571
            ..            :|:.           :.:|.|:...:.:   :.|:..|.|.:.|::... .
 Worm   435 RDKLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQRGT 499

  Fly   572 LTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPR-------STLHFI 629
            .|:...:|||.....||.::|...:.:.:|.|...:|.....|..|...:.|       |...|.
 Worm   500 ATRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQIFT 564

  Fly   630 NIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFF 694
            ....|::....|      ..|...:.|.:    |.:.|    |...|:|   |..|....||:.|
 Worm   565 EDHTPVIKSEEL------HYFDPAMKKIW----KNYAD----RNERALI---TPQFGKKCDMYSF 612

  Fly   695 VTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTER---VLY---- 752
                                          |::..|.:|...||||:.|: |.|.   ||.
 Worm   613 ------------------------------GVILHEIILKKKFVEQLFDS-PREEDDSVLIDDEN 646

  Fly   753 PSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRY 817
            .:..|.|.:.|:|... |.....|.|:|       .:|:.:  :..|: ||.     :.||.|..
 Worm   647 DAIASRFPLPIIIPEG-IEMHNDLIKML-------ENCFGS--VRPDI-ALA-----RKIIDTVL 695

  Fly   818 AASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAE-QKETANDMRQRNEALVYNVLPVHVAEHF 881
            ..||.|:  .|.:..|..:....:..:   |...|| :||     :::.:.|:..:||..||
 Worm   696 KMSGSLV--DLMIKNLTAYTQGLNETV---KNRTAELEKE-----QEKGDQLLMELLPKSVA--- 747

  Fly   882 MKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQF 946
              |..::...:..:.|....:|::.:..|:...|:    :|.:|.:..|:.:...||.::..
 Worm   748 --NDLKNGIAVDPKVYENATILYSDIVGFTSLCSQ----SQPMEVVTLLSGMYQRFDLIISQ--- 803

  Fly   947 QDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVL 1011
            |...|::|||..|..|:|:          |:.....|:..:...||        :.....:||.:
 Worm   804 QGGYKMETIGDAYCVAAGL----------PVVMEKDHVKSICMIAL--------LQRDCLHHFEI 850

  Fly  1012 ----------KMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRL 1066
                      :.|.|.||:.|||||.:.|.|..:|..|.:||:|||:|....||:|..:..:|..
 Worm   851 PHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSGVEDRIQMTLASQQLLEE 915

  Fly  1067 FGYTFL--QRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVESTSELEASDIKM 1129
            ....|:  .||...::|.|:::|::|:|.:......|......||.:.|..::...||.|:...:
 Worm   916 NFPQFVCSNRGGRTIEGIGRILTYWLEGVNAGEQVKVVEFQNDLNDELSRIMKKDGELLAAATAL 980

  Fly  1130 -PLLKMNGPEQSL---EIDQDRSLRNDSAGQESVAECQSLLE 1167
             |..||...::.:   ..:::..|:.....||::.|.:..:|
 Worm   981 KPKDKMTLAKEKVIAERKNEEERLQRQQTLQEALEEHEEEIE 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	7/33 (21%)
		CYCc	256..453	CDD:214485	53/256 (21%)
		Guanylate_cyc	294..476	CDD:278633	52/258 (20%)
		CYCc	860..1071	CDD:214485	52/220 (24%)
		Guanylate_cyc	892..1092	CDD:278633	53/211 (25%)
daf-11	NP_505960.3	Periplasmic_Binding_Protein_Type_1	<33..295	CDD:299141	51/245 (21%)
		PKc_like	447..695	CDD:304357	63/311 (20%)
		HNOBA	<714..750	CDD:285003	11/48 (23%)
		CYCc	729..922	CDD:214485	55/227 (24%)
		Guanylate_cyc	756..943	CDD:278633	53/211 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810