Protein Alignment Ac3 and acy-4

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1104
• Identity: 342/1104 - (30%)
• Similarity: 526/1104 - (47%)
• Gaps: 242/1104 - (21%)

  Fly    58 YHNYSIKQRRSGLKWFVF--------------------AAALFNIWTIGIPWDQSAPTRVINCCM 102
            |...|.|::||.|..|.|                    :.|.|:  ..|..|.:|     :..|:
 Worm    69 YRKNSQKKKRSTLYSFYFEQVNSGRIQFSFVILLSICISEAAFS--AFGAEWLKS-----LILCI 126

  Fly   103 LLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAI 167
            |...:::.:..|..|..                     |:.|......||:....|.|..:.:
 Worm   127 LTLVISILSFFHAKRTE---------------------LVCIASIISCVIISACTSMRTSVTY-- 168

  Fly   168 LLNFLVYVTLPLQLIFLGLSIGCITYFIC-----LSLPVGYSHWDSLLSNQLAANAVLIATAALI 227
            ||.|..|..||:..:.:..|...:|:.:.     :...||:   |.:|:     ..:::....::
 Worm   169 LLIFSTYSLLPMSFMLMIFSTFALTFLVAFIGVLMDYNVGF---DIILT-----RVMMVILVNVV 225

  Fly   228 GLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE-AF 291
            |.|.|:..|..|::.|.|.:|.::.:|:::::...||::||:||||::|.::::|:..:..| .|
 Worm   226 GSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILLAVLPKNIAFEVKKDMQETHEERMF 290

  Fly   292 KKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYC 356
            .|||:.::|::|||:|||.|||.::|.|:.:|||.||||||||||::|..:|.:|||||||||||
 Worm   291 HKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKVASIHQCMRIKILGDCYYC 355

  Fly   357 ISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSK 421
            :.|.|:.:.:||:..|.||..|::||:.|::.....|:||||||||....|:||.::|||||:|.
 Worm   356 VCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGKAHCGVLGLKKWQFDVWSN 420

  Fly   422 DVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASP 486
            ||.|||:|||.|.||||||:|.|.::|.|.:.:|...|..|.:.|....:||:.:......:.:.
 Worm   421 DVTLANQMESGGLAGRVHITDATRSYLKGAYILEEGNGGSRSKFLEKEKIKTWLVVDRSPDYDNI 485

  Fly   487 CAKKINETQAEIAHP--NPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQ 549
            |.:..|       ||  .|..||..|...|.....:........:|.:|             ||:
 Worm   486 CQEATN-------HPVMVPWKSTRGISKQERLTGMSTRTRGASTRNGLS-------------EEE 530

  Fly   550 VKLENFKQRLKDELVTRDGHENLTKDT-------NIFLRFKNPQLEQLYAVYREPYSSLP----L 603
            |.:||....|      |.|.:.:.::.       |..|::|..::|..:.  |..|..:|    |
 Worm   531 VLVENVDSHL------RQGIQAIHQENWKTMHCKNWSLKYKQVRVENKFV--RLKYKDIPFQVTL 587

  Fly   604 LAALLVQCIDV------LYSYLVLPR------STLHF----------------INIAAPLVPIAM 640
            ..|::..||.:      |.|:..:|:      |.:.|                |.:...|:.|.:
 Worm   588 YVAIVAICIGIKFGLMNLVSFSFVPQMFIVLTSVMIFILTRALIKHARLVSLVIGVLFILLSIQI 652

  Fly   641 LVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVS 705
            ::::.:.||      ||..||.|.|.                   :|..|.|
 Worm   653 VILMGMYES------KFTCDVEKCFK-------------------NNYTDFF------------- 679

  Fly   706 ESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVI 770
              |.....:|.:.:.|.|:.|                    |:.::...|.|:|.|||      .
 Worm   680 --EIFEICTLATCVILSVDFM--------------------TKLLMSMIYFSSFTVLI------T 716

  Fly   771 AQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLAR 835
            |:|..:.:...|||..|..|..:...:                        ||:|.:...|.|..
 Worm   717 AKLIRINQYEALLSTYANFCVLSCLTL------------------------LLVVFSTRRSELIS 757

  Fly   836 HMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEV 900
            ..|      |.||.:..:::.......::|.:::.|:||.|||:||:::. .|...||.:|....
 Worm   758 RYD------FIWKLQALDEQLQMKRKHEQNRSVLENILPSHVAKHFVEDA-TSVSKLYHESRDNA 815

  Fly   901 GVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDF----DALLELPQFQDIIKIKTIGSTYMA 961
            .::||::..|..||.|...||:|:||||.|||:||||    |.:|:..:|:.|.|||||.:|||.
 Worm   816 CIMFATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMV 880

  Fly   962 ASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIG 1026
            |||:..:....|        ||:..:..||.||...|:|.|..|||:|.|::|||.||:.|||||
 Worm   881 ASGLAGRECGDN--------SHVEAIALFARELLVKLESTNIHSFNNFNLRIGINVGPVVAGVIG 937

  Fly  1027 ARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYL 1090
            :.|||||||||:|||||||:|.|.||.||||||..:||...||.|..||.:.|||||.:.||:|
 Worm   938 SDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILEPLGYNFECRGQINVKGKGMMETFFL 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	128/338 (38%)
		Guanylate_cyc	294..476	CDD:425528	94/181 (52%)
		Guanylate_cyc	892..1092	CDD:425528	104/203 (51%)
acy-4	NP_504486.4	AcyC	93..455	CDD:441717	137/399 (34%)
		Guanylate_cyc	293..448	CDD:425528	86/154 (56%)
		Guanylate_cyc	807..1003	CDD:425528	104/203 (51%)