Protein Alignment Ac3 and gcy-18

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 958
• Identity: 191/958 - (19%)
• Similarity: 334/958 - (34%)
• Gaps: 275/958 - (28%)

  Fly   202 GYSH-WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQER 265
            ||.| :|||....||...||..|.   ...|...|:....|     .:.::.:.|:...|:|:.:
 Worm   349 GYLHLFDSLKLYALAIRKVLNETD---NEAYVTNGQFIWNR-----MRRMKFEGVVSRSSSEENK 405

  Fly   266 ---LLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKM 327
               .:.:||...||         ..:..|...|:|.:.:                  ....:|.|
 Worm   406 DAGAIGTVLMDDVA---------DRAPIFSAFYISPNRD------------------KVMKMVNM 443

  Fly   328 LNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSP 392
            .:||.:..|.|..|                ||           |..:.::.:|:..:..:..:.|
 Worm   444 ESELISNCDGLKNK----------------SG-----------CFQLKINDIKSGFWPSEDGSMP 481

  Fly   393 VDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAA 457
            :|        ..:.|..|||            .:..:|.|  .|.:.|
 Worm   482 LD--------EPICGYRGQR------------CSYLLEIS--VGSLII----------------- 507

  Fly   458 FGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATLD 522
                   ||.:..:..:|:.:..:      .|::.:....|.|                     |
 Worm   508 -------LLILISVVFFFLFRYCE------NKQLEKMPWRIFH---------------------D 538

  Fly   523 DEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELV----TRDGHENLTKDTNIFLRFK 583
            |.:.:.:..|.:...:|...|       ||.|.:...|...:    |...:....:...|  :|.
 Worm   539 DLQFIDEEQVKSMMSVGSVTT-------KLSNIQTGQKQHAIIGVNTHTTYHRYKQRRPI--KFI 594

  Fly   584 NPQLEQLYAVYREPYSSL-PLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLA 647
            ...::.|..:.:..:.:| |.|.|...:..::|..:....|.|:..|...|.:|         |.
 Worm   595 KEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVV---------LD 650

  Fly   648 ESFSGMLPKFFVDVSKRFNDITFVRELA---AIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEF 709
            |.|.|                .|||::.   ..:.|..||:...:..  :...:....:|..|::
 Worm   651 EKFHG----------------AFVRDITLGLEYLHASPIGYHGSLTP--WCCLIDRNWMVKLSDY 697

  Fly   710 NVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLY--PSYLSN-------------- 758
            .:...||   ....:|.:   .:..|...:....|.....::|  |..|.|
 Worm   698 GIANPLE---RWEKQGAI---EIAAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWV 756

  Fly   759 --------------FGVL---ILIAIAVIAQLTHLTKILLLLSIAA------------LHCYFNI 794
                          ||::   ||.........|::::::..|:..:            ||
 Worm   757 KQSMLRRQAGDIYSFGMVMYEILFRSLPFRDNTNISELVDYLADGSKTVSPEIQNQMGLH----- 816

  Fly   795 FIMQDLYA-LEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTE----VAEQ 854
               .||.| |.|.:...|.|  |.:...:.|...:.|.|....:|...:::.::...    |||:
 Worm   817 ---PDLNALLRDCWSENPEI--RPSIRRVRLNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAER 876

  Fly   855 KETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETV 919
            .....:...|.:.|:..:||.:||     |..:....:..:.|:...:||:.:..|:...|..|
 Worm   877 TGMLEEANIRADQLLTQLLPAYVA-----NELKMGRSVAPKLYSSATILFSDIVGFTTICSGST- 935

  Fly   920 NNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHL 984
               .||.:..||.:.:.||   |........|::|||..||..|||          |....::|.
 Worm   936 ---PLEVVNMLNGLYTGFD---ECITRNKSYKVETIGDAYMVVSGI----------PEENEYNHS 984

  Fly   985 AILVEFALELKHAL--QSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMES 1047
            ..:...||:::..|  ..|..:..:....:.|.:.|.:.|||:|...|.|.::|:||||:|||||
 Worm   985 RNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMES 1049

  Fly  1048 TGKAGAIQVTEETCNILRLFG--YTFLQRGLVAVKGKGQLMTFYLQGK 1093
            ||..|.||::||....:|...  :|..:||.|.|||||...||:|:.:
 Worm  1050 TGTPGMIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDR 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	21/86 (24%)
		CYCc	256..453	CDD:214485	30/199 (15%)
		Guanylate_cyc	294..476	CDD:278633	25/181 (14%)
		CYCc	860..1071	CDD:214485	61/214 (29%)
		Guanylate_cyc	892..1092	CDD:278633	66/203 (33%)
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141	27/133 (20%)
		ANF_receptor	87..395	CDD:279440	14/53 (26%)
		PKc_like	549..846	CDD:304357	58/348 (17%)
		HNOBA	<857..903	CDD:285003	10/50 (20%)
		CYCc	882..1073	CDD:214485	61/212 (29%)
		Guanylate_cyc	909..1095	CDD:278633	65/202 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810