DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and acy-1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	1300	Identity:	338/1300 - (26%)
Similarity:	527/1300 - (40%)	Gaps:	389/1300 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 RSGLKWFVFAAALFNIWTIGIP---------WDQSAPTRVINCCMLLAYLALTALLHIGRRSDKP 122
            ||||   ::.|.:...||:.:.         |..|    :..|.::.|..|.||.        ..
Worm    67 RSGL---IYIAVVIAAWTLYLALFDRTFIQHWIVS----LCLCAIIFAMFAFTAC--------AA 116

  Fly   123 ALRRFHQILLIIVPRALWLLSILHFTVYVILQPSF-SPRDLLGWAILLNFLVYVTLPLQLIFLGL 186
            ..:||:.....:....:.|:::|.|:..  .|.:| :|...|..:..:..|:|..:||.|
Worm   117 QYQRFYMPTSFLCTFLICLVTLLIFSAE--NQAAFMTPVASLATSFQVVLLIYTVIPLPL----- 174

  Fly   187 SIGCITYFICLSLPVGYS-HWDSLLSNQLA------ANAVLIATAALIGLLYYFMGEAKQKRAFL 244
                   ::|:.:.:.|| .::.|..|::.      ...||.|...|:|:..:.:.:.:|::.||
Worm   175 -------YLCILIGIIYSILFEILNKNKIGLEEAGYIKLVLHAGVHLLGVHLFILTQVRQRKTFL 232

  Fly   245 EAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLG-----SSSSEA-------------- 290
            :..:|:..:..:|.::..::.::.||:||.||.::.:|..     |:|:::
Worm   233 KVGQSMLARKDLELETQFKDHMIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPL 297

  Fly   291 ---------FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLR 346
                     |:...|:...|||||:|||.|||.:||..||.:||.:||:||.|||.|.......:
Worm   298 AKMVPEYRKFRPFTMNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEK 362

  Fly   347 IKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQ 411
            |..|||||||::|.|:...|||...|.|||.|:.||:.........|:||||||||.|:.|::|.
Worm   363 ISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGT 427

  Fly   412 RQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAA---FGEKR------EELLR 467
            ::::|||:|.||.|||:|||||.|||||:|:.|...|.|.:|:|..   .|..|      |..::
Worm   428 KRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQVQGTERRVK 492

  Fly   468 IAGLKTYFI---------------TKVVKAFASPCAKK--INETQAE---IAHPNP--------- 503
            ...:||:||               .:|....:...:||  :.:..||   :.|.|.
Worm   493 PESMKTFFIKGRINDGVEEEVMQVQEVESLHSQKSSKKSTLKQKWAEKLKMNHTNSYPMRAAARE 557

  Fly   504 -NGS----------TTDIVSDEDDNDATLDDE------ELLAQNSVSNGH--------QIGIA-- 541
             .||          :|.::..|.::...::|.      :.||.|:.:..:        :.|:|
Worm   558 GGGSLRIKLAERNRSTQLLPKESNSICIMEDNRKSASLQALATNNFNGSNTDTNNTYSERGVAGS 622

  Fly   542 -----VTADEEEQVK-----------------------LE-------------------NFKQRL 559
                 |...|...:|                       |:                   ||.|||
Worm   623 VSKKSVAGSESNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAISHHHNAASLTRFDTDNNFDQRL 687

  Fly   560 KDELVTRDG---------HENLTKDTNIFLRFKNPQLEQLYAVY----REPYSS----------- 600
            ...:...:|         |::|.|.|   |||....:|:.|..:    .|.|::
Worm   688 AMVIGQGEGGFDKGFWNHHDSLNKWT---LRFNEKDVEEEYRAHFVDSSERYTASKKGHVERHKD 749

  Fly   601 --------------------------------------------------------LPLLAALLV 609
                                                                    .|..||:|:
Worm   750 LMEQGGEKDGITGSTVNKYRYSGVFIDIIVATLIFVISGAVAIMSVRPFPLSLIAYFPFAAAILI 814

  Fly   610 QCIDVLYSYLVLPRS----------TLHFINIAAPLVPIAMLV-VISLAESFSGMLPKFFVDVSK 663
            ..| ||....:|.|.          ..|.|.:....:||.:.: ::.|.:  ||......::...
Worm   815 LTI-VLIGLPLLARKKSFQCANQWMPRHLIGLLLIFLPIGVAICIMPLCQ--SGDCANVILNYRL 876

  Fly   664 RFNDITFV--------RELAA---IIIALTIGFSNVIDMFFFVTFVRTEHIVSESE-FNVTA--- 713
            .|:.:|.:        .:|||   ...|:.||..::..:|:  .....:|:|.|.: .||||
Worm   877 AFSYVTILAIFAHCNFSQLAAWPKTTAAVFIGLLHIAGVFY--CEFNLKHLVEEQDTCNVTAIMI 939

  Fly   714 -SLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLT 777
             .:...:|..:....|:...|...|..             |.::....:.::::|.::|.|.
Worm   940 PPIRKGLNYTIALNSTSARTLSQDFGS-------------PLFIWELLLDVILSIVLVAFLN--- 988

  Fly   778 KILLLLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDR 842
                                   |..|..|                                  |
Worm   989 -----------------------YQFETAF----------------------------------R 996

  Fly   843 VIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASM 907
            :.|....:.....|....:|.:.:.|:.||:|.|..|....:||      ||:::..|||||||:
Worm   997 MSFFGDVQARRDTERMQIVRDQADWLLNNVIPAHAVESLKTDTK------YSENHETVGVLFASI 1055

  Fly   908 PNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVR 972
            .|::|.|.|..  ..|.|.||.|||||.|||.||:.|.|..|.||||||..||||||:|.:|...
Worm  1056 TNWNDMYEENF--EGGREFLRVLNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASGLNPERKKN 1118

  Fly   973 NDAPITERWSHLAILVEFALELKHALQSINEQSFN-HFVLKMGINHGPITAGVIGARKPHYDIWG 1036
            ...|    ..||..:|:|||.::|.|...||...| .||.|:|:|.||:||||||..|.:|||||
Worm  1119 MLHP----KEHLYQMVDFALAVQHVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWG 1179

  Fly  1037 NTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG-KGQLMTFYLQGKSQSSAEP 1100
            :|||:||||.|||....|||::.|...| |..|.|..|..:.||| .|.:.|:.|.|:......|
Worm  1180 DTVNIASRMYSTGVLNRIQVSQHTREYL-LDRYEFEFRDHIEVKGIDGGMDTYLLVGRKGDGIPP 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	35/170 (21%)
		CYCc	256..453	CDD:214485	92/224 (41%)
		Guanylate_cyc	294..476	CDD:278633	88/190 (46%)
		CYCc	860..1071	CDD:214485	101/211 (48%)
		Guanylate_cyc	892..1092	CDD:278633	100/201 (50%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	22/109 (20%)
		CYCc	297..469	CDD:214485	82/171 (48%)
		Guanylate_cyc	317..503	CDD:278633	89/185 (48%)
		SDF	<773..982	CDD:294387	37/226 (16%)
		CYCc	1016..1215	CDD:214485	102/211 (48%)
		Guanylate_cyc	1041..1235	CDD:278633	100/200 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810