Protein Alignment Ac3 and gcy-29

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001364597.1
• Gene: gcy-29 / 175116
• WormBaseID: WBGene00007314
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1031
• Identity: 212/1031 - (20%)
• Similarity: 379/1031 - (36%)
• Gaps: 272/1031 - (26%)

  Fly   217 NAVLIATAALIGLLYYFMGEAKQKRAFLEAK---------KSLEV-----------KMVIEEQSA 261
            |::..||||       ||......:|.:.|.         :|||.           :::.||.::
 Worm   147 NSISEATAA-------FMAHHNITKAAIVANIGTDSFEKIQSLEKALRSRGITVARRVMFEEAAS 204

  Fly   262 EQE--------------RLLLSVL--PKHVAIKMRED--LGSSSSEAFKKIYMS------RHENV 302
            .|:              |::|.:.  .:.::...|..  |.:.:|..|  ||::      ..|..
 Worm   205 AQDLVDNGYMNELRDNARVILPIFSSTRDLSTVFRNATWLANMASPEF--IYINPLIVARNSEEP 267

  Fly   303 SILY---------ADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCIS 358
            .:.|         |:......|.::|...|  .:|||..|.||      |..||.|
 Worm   268 PVFYGKMAQKSIKAENPNTIQIYNSYGFSD--DLLNEFLAIFD------QNQRIYI--------- 315

  Fly   359 GAPDERP--DHAVL----CVHMGLSMVKAIKYVQQKANSPVD------------MRVGIHTGAVL 405
               ||:.  ::..|    ||...|:.    ||:......|.|            |.||:....||
 Worm   316 ---DEKDLFNYVALYESFCVFAKLTE----KYLHSLKEKPEDGKIRIDGKALWNMAVGMTFQGVL 373

  Fly   406 AGIL----GQRQWQFDVYSKD--------VELANKMESSGKAG-----RVHISDKTLAFLNG--- 450
            ..::    .:|...|..:..|        |.|.|...:|....     .:.:||....|.:.
 Worm   374 DNVIFDNGAERMTSFSAFYVDEKRDQIRTVSLINSTVTSKNCMDPVCIELVVSDVVTKFWSSPSG 438

  Fly   451 ---EFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVS 512
               :.|.|..|.|:..:..:...:.|..:..::..|.....::..||.|               .
 Worm   439 KLPDSEPECGFREENCDYTQTIVIATAVVCIILTVFLGIWLRRACETSA---------------L 488

  Fly   513 DEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELV----TRDGHENLT 573
            |:.......||.::|.:..|.:...:..|.|...:.:.||      :|:..:    |...::...
 Worm   489 DKMPWRVFRDDVQILDEEQVKSVVSLNSASTKMSQVETKL------IKNHAIVGVNTHAVYDLYE 547

  Fly   574 KDTNIFLRFKNPQLEQLYAVYREPYSSL-PLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVP 637
            :..||  ||....|..|..:.:..:.:: |.:.....:..::|..:....|.||.         .
 Worm   548 QRQNI--RFTREDLILLTKMKQAVHDNINPFIGVSFNEKSELLLLWKFCSRGTLQ---------D 601

  Fly   638 IAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELA---AIIIALTIGF-------SNVIDMF 692
            :......::.|.|.|                .|||::.   ..:.:..||:       |.:||..
 Worm   602 VIYCEKFAMDEKFQG----------------AFVRDITMGLEYLHSSPIGYHGGLACWSVLIDKN 650

  Fly   693 FFVTFVRTEHIV--------------------SESEFNVTASLESDINLVVEGMVTAEHLLPASF 737
            :.:..  |::.|                    :|.::...|||     .|...:.||..   .:.
 Worm   651 WMLKL--TDYAVCDPLKRWEKHGRINCKVDNEAEKQWQKMASL-----YVPPEIRTANE---KNR 705

  Fly   738 VEQMRDAVPTERVL--YPSYLSNFGVL---ILIAIAVIAQLTHLTKILLLLS----IAALHCYFN 793
            :::|......:.:|  ..|.:..|||:   ||.......:...||::....:    |.......|
 Worm   706 LKRMDQKWQGQTILKRQQSDIYAFGVIIYEILFRSLPYDEKVDLTELAQKAAEGDKIQKPSIQRN 770

  Fly   794 IFIMQDLYA-LEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTE----VAE 853
            ..:..||.| |:|.:..||  ..|.....:.|...:||.|....:|...|::.::...    |.|
 Worm   771 KKLNPDLIALLQDCWSDQP--DMRPTIRRVRLATEIALKTKGNLVDSMMRMMEEYANNLEKLVGE 833

  Fly   854 QKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEET 918
            :.:.|.:...|.|.|::.:||.|||...     ::...:..:.|....|:|:.:..|:...|..|
 Worm   834 RTKLAEEANLRAERLLFQLLPKHVAIEL-----KAGRTVAPKMYDSATVMFSDIVGFTKLCSAST 893

  Fly   919 VNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGI---NVQRTVRNDAPITER 980
                .:|.:..||::.|:||.::..   .|..|::|||..||..|||   |.||.|.|.:.:|
 Worm   894 ----PIEVVNLLNKLYSEFDTVISK---HDCYKVETIGDAYMVVSGIPIENGQRHVANISAVT-- 949

  Fly   981 WSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRM 1045
               |.|     ::|....:..:.:.: ...:::|...|.::|.|:|...|.|.::|.|||:|:.|
 Worm   950 ---LGI-----MDLLKVFEVPHRRDY-RLTIRLGFASGQVSAAVVGLSSPRYCLFGETVNIAAVM 1005

  Fly  1046 ESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG------KGQLMTFYLQGKSQ 1095
            ||:|:.|.:|:| ||..||....|   ...::.::|      :...:|::|.||.:
 Worm  1006 ESSGEGGRVQIT-ETSKILLENEY---PEFIIEIRGINKDVKQDDFVTYWLTGKDE 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	19/105 (18%)
		CYCc	256..453	CDD:214485	52/270 (19%)
		Guanylate_cyc	294..476	CDD:278633	48/237 (20%)
		CYCc	860..1071	CDD:214485	63/213 (30%)
		Guanylate_cyc	892..1092	CDD:278633	58/208 (28%)
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575	57/288 (20%)
		PKc_like	534..804	CDD:419665	53/308 (17%)
		CYCc	840..1033	CDD:214485	63/219 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810