DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	365	Identity:	98/365 - (26%)
Similarity:	158/365 - (43%)	Gaps:	78/365 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   799 DLYAL-----EDDFEHQP----IISTRYAASGLL-----------LVAALALSTLARHMDHEDRV 843
            ::|.|     |:|.|.:|    |.||.....||.           |:..|.|  .:|:::|
Mouse   718 EVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQL--YSRNLEH---- 776

  Fly   844 IFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMP 908
                  .|.|:.:.....|.|.:.|.:.:||..|    :|:.|.. ..:..:.|.||.:.|:.:.
Mouse   777 ------LVEERTQLYKAERDRADHLNFMLLPRLV----VKSLKEK-GIVEPELYEEVTIYFSDIV 830

  Fly   909 NFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRN 973
            .|:......|    .:|.:..||::...||.:::   ..|:.|::|||..|:.|||:
Mouse   831 GFTTICKYST----PMEVVDMLNDIYKSFDQIVD---HHDVYKVETIGDAYVVASGL-------- 880

  Fly   974 DAPITERWSHLAILVEFALELKHALQSINEQSFNHFV-----LKMGINHGPITAGVIGARKPHYD 1033
              |:.....|...:.:.||::   |..|......|..     :::|::.||..|||:|.:.|.|.
Mouse   881 --PMRNGNRHAVDISKMALDI---LSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYC 940

  Fly  1034 IWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQ--RGLVAVKGKGQLMTFYLQG-KSQ 1095
            ::|:|||.||||||||....|.::..|..||:.....||.  ||...:||:|...|::|.| |.|
Mouse   941 LFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQ 1005

  Fly  1096 SSAEPVASGVVVLNGQDSSAVESTSEL--EASDIKMPLLK 1133
            .           .|......||:...|  |.||:.:..|:
Mouse  1006 E-----------YNLPSPPTVENQQRLQTEFSDMIVSALQ 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485
		Guanylate_cyc	294..476	CDD:278633
		CYCc	860..1071	CDD:214485	60/215 (28%)
		Guanylate_cyc	892..1092	CDD:278633	61/206 (30%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141
		PKc_like	480..749	CDD:304357	9/30 (30%)
		STYKc	502..744	CDD:214568	8/25 (32%)
		CYCc	787..978	CDD:214485	60/215 (28%)
		Guanylate_cyc	814..1001	CDD:278633	61/206 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900