DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and gucy2f

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	976	Identity:	195/976 - (19%)
Similarity:	331/976 - (33%)	Gaps:	311/976 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 VGIHTGAVLAGILGQRQWQFDVY----SKDVELANKMESSGKAGRVHI-----------SDKTLA 446
            :.|.|.|.||..|..|.....:.    :.|..|.|.:.|...||.:.:           .::...
Zfish   202 IWIDTAAKLASALRNRGLPVGIVTSMGNNDTMLENTLMSIKNAGDIKVIIMCMHSVLIGGEQQAT 266

  Fly   447 FLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIV 511
            ||...:::..|.|            :..||......::.|   .||.|...:.:.:......|.|
Zfish   267 FLTKAYDMGLASG------------RYVFIPYDTLLYSLP---YINITYYPLQNNSKLSKAYDAV 316

  Fly   512 SDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVK-----LENFKQRLKDEL--VTRDGH 569
            .     ..|||.:.:....:.:...|:|..:...|.|||.     :.|....|...:  ..|.|.
Zfish   317 L-----TITLDSDIMTFNEAFNAAKQLGELMVTQEPEQVSPLFGTIYNSLYLLAKSMHNARRAGR 376

  Fly   570 ----ENLTKDT-NIFLRFKNPQLE---------------------QLYAVYR-EPYSSLPLLAAL 607
                .||...| ||.....|..::                     |||..:. :..|.|.|.|..
Zfish   377 WLSGTNLAYFTRNITFTGFNQDIQTDEQGNGQTNYVILDTEAWGTQLYRCFLVDMTSDLVLFAGR 441

  Fly   608 LV------------QC-----------IDVLY--------------------------------- 616
            .:            :|           :|::|
Zfish   442 FIHFPGESPPPSDSRCWFEDNAICTGGVDIIYVIIAFVIVLIIVLGSIGLSLFIRRRIQQIQLIK 506

  Fly   617 --SYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDI----------- 668
              :.::|....|.|||   |.:....:.:..|::|.|.:..|...|.|:..|.:
Zfish   507 GPNRILLTLEDLTFIN---PQLSKRKITLEDLSDSKSYIEEKSTGDRSRSVNSMATATHETSNVA 568

  Fly   669 ----------------------------TFVRELAAIIIALTIGFSNVIDMFFFVT--------- 696
                                        |.:::|....:...:||....:||..||
Zfish   569 VYEGDWVWLKKFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLH 633

  Fly   697 -FVRTEHIVSESEFNVTASLESDI--------------------NLVVEG--------------- 725
             .:|.:.:..:..|.  :||..|:                    |.||:|
Zfish   634 DLLRNDDVKLDWMFK--SSLVLDLIKGMKYLHHREFPHGRLKSRNCVVDGRFVLKITDYGYNEIL 696

  Fly   726 ---MVTAEHLLPASFV----EQMRDAVPTERVLYPSYLSNFGVLILIAIA--------------V 769
               ....|.|.|....    |.:||.....:..|...:.:|.:::...:.              :
Zfish   697 ETQKAPKETLPPEDLFWTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEI 761

  Fly   770 IAQLTH---LTKILLLLSIAALHCYFNIFIMQDLYALEDD--------FEHQPIISTRYAASGLL 823
            |.::..   :.:..:....|.|.|   |.:|:..::.:.|        |:...:|:.....:
Zfish   762 IRKVKKPPPMCRPTVAPDQAPLEC---IQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTN--- 820

  Fly   824 LVAALALSTLARHMDH-----EDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMK 883
                 .:.::.|.::.     ||  :.:.:||..|.:      :||.|.|:..:||..|||..
Zfish   821 -----IIDSMLRMLEQYSSNLED--LIRERTEELEVE------KQRTEKLLSEMLPPSVAEAL-- 870

  Fly   884 NTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQD 948
            .|..|.:..|   :.:|.:.|:.:..|:...|    .:..:|.:..||::.|.|||:|   ...|
Zfish   871 KTGASVEPEY---FDQVTIYFSDIVGFTTISS----LSDPIEVVDLLNDLYSLFDAVL---GSHD 925

  Fly   949 IIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFV--- 1010
            :.|::|||..||.|||:          |......|.|.:...:|.:   |.|:......|..
Zfish   926 VYKVETIGDAYMVASGL----------PKKNGNKHAAEIANMSLNI---LSSVGSFKMRHMPEVP 977

  Fly  1011 --LKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLF--GYTF 1071
              :::||:.||..|||:|...|.|.::|:|||.||||||||....|.|...|..|||..  ||..
Zfish   978 VRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLNDGYKI 1042

  Fly  1072 LQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVVLNGQDSSAVESTSELEASDIKMPLLKMNG 1136
            ..||...:||||...|::|.||: :..:|:.:...:..|      ::..::...:||....|.|.
Zfish  1043 DVRGKTELKGKGIEETYWLVGKA-NFTKPLPNPPEIKPG------DNWQDMMTEEIKSLFRKANR 1100

  Fly  1137 P 1137
            |
Zfish  1101 P 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485	15/70 (21%)
		Guanylate_cyc	294..476	CDD:278633	17/93 (18%)
		CYCc	860..1071	CDD:214485	71/217 (33%)
		Guanylate_cyc	892..1092	CDD:278633	68/206 (33%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	50/257 (19%)
		PK_GC-2D	551..816	CDD:270945	36/269 (13%)
		HNOBA	<825..870	CDD:311573	15/52 (29%)
		CYCc	850..1042	CDD:214485	71/222 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900