Protein Alignment Ac3 and LOC1272957

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_061519369.1
• Gene: LOC1272957 / 1272957
• VectorBaseID: AGAMI1_006876
• Length: 1413
• Species: Anopheles gambiae
• Alignment Length: 969
• Identity: 332/969 - (34%)
• Similarity: 525/969 - (54%)
• Gaps: 142/969 - (14%)

  Fly   164 GWAILLNFLVYVTLPLQL--IFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAAL 226
            |..::..:::|..||::|  ..:|.|:..|::   ::|....:..|.:  :.|..:.:.:|....
Mosquito   553 GCTVIAIYIIYTMLPIRLREAVVGGSLLSISH---IALMFYMNESDDM--DVLYCDLITLACTNA 612

  Fly   227 IGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEA- 290
            .|:|.::..|..|::||:|.::.:|.::.|:.::.:||:|||||||:|||::|:.|:.....||
Mosquito   613 TGILLHWPKEKSQRKAFMETRQCVEARLKIQRENQKQEQLLLSVLPRHVAMEMKNDIAGQPREAQ 677

  Fly   291 FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYY 355
            |.|||:.||||||||:|||.|||::|...:|::||::||||||||||||:::..||||:||||||
Mosquito   678 FHKIYIQRHENVSILFADICGFTSLSDQCTAEELVRLLNELFARFDRLAQEHHCLRIKLLGDCYY 742

  Fly   356 CISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYS 420
            |:||.|:.|||||:..|.|||.|:.||..|::.....|:||||||||.|..|:||.|:|||||:|
Mosquito   743 CVSGLPEARPDHALCAVEMGLDMIDAIALVREVMAVNVNMRVGIHTGRVHCGVLGLRKWQFDVWS 807

  Fly   421 KDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAF-- 483
            .||.|||.|||.|..|||||:.:||..|...::||...|..|...|:...::||.|.....::
Mosquito   808 NDVTLANYMESGGVPGRVHITKETLRCLGDHYDVEEGRGADRNSYLKDHQIQTYLIVPKDASYRP 872

  Fly   484 ------ASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAV 542
                  :|.....|::....:.|.:..|     .:|:.:..:|  :||:       |.:.|. |:
Mosquito   873 HTMSKQSSSVNGNISKELRMMGHWSKMG-----FNDKTEPKST--EEEV-------NEYLIK-AI 922

  Fly   543 TADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREP----YSSLPL 603
            .|...::::|::.|:                    ..|.|...::|:.|.:..:|    |....:
Mosquito   923 DARSIDRLRLDHCKR--------------------FHLTFIKDEIERKYCLEPDPMLNVYFYCSI 967

  Fly   604 LAALLVQCIDVL------YSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVS 662
            :..|.:..|.||      |||.|....:|..:....|:.....:.|.:           ||..:|
Mosquito   968 IIFLGIMSIQVLVFSMDHYSYWVYGILSLTLLVSCVPVFTREDMKVST-----------FFRALS 1021

  Fly   663 KRFN---DITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVE 724
            ::.:   :|..|..|..:|..:.:.:.. :.:.|:::......:|..|....:..:...:.|.:.
Mosquito  1022 QKIHGHREIAQVISLCVVITVICLSYYK-LTLIFYLSLYDEFPLVRPSNCKESKIINILLLLTLL 1085

  Fly   725 GMVT-AEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAAL 788
            .::| |.|    .|::.:                 |.:|:||.|.|:    ::..|::|..|...
Mosquito  1086 ALLTCAVH----QFIKIL-----------------FKILLLIVILVL----YIASIIVLALIFER 1125

  Fly   789 HCYFNIFIMQDLYALEDDFEHQP--IISTRYAASGLLLVAALALSTLARHMDHED-----RVIFK 846
            ||                   :|  :.:.|:    |:.||.|.:..:.:.|..:.     |:.|.
Mosquito  1126 HC-------------------EPWFLTTERF----LIDVAFLVVFVIGQIMHSQQTEITRRLDFI 1167

  Fly   847 WKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFS 911
            ||.:..|:||....::..|..|:.|:||||||:||:...| :.:::|.:....|.|:|||:||||
Mosquito  1168 WKLQATEEKEDMEHLQAYNRKLLANILPVHVADHFLMREK-NIEEIYHEQCDTVCVMFASIPNFS 1231

  Fly   912 DFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAP 976
            :||.|...||:|:||||.|||:|.|||.||.|.:|:.:.||||.|||||||||:......:||
Mosquito  1232 EFYIELEGNNEGVECLRLLNEIIVDFDELLGLERFRYVEKIKTTGSTYMAASGLTANSCDKND-- 1294

  Fly   977 ITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNV 1041
                :.|:..::::||||...:..:||.|||:|.:::|||.||:.|||||.|||.||||||.|||
Mosquito  1295 ----FQHVFAMMDYALELFQKITDVNEHSFNNFRMRIGINIGPVVAGVIGTRKPQYDIWGNAVNV 1355

  Fly  1042 ASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEP 1100
            ||||:|||....|||||:...|::..||....||.|.|||||.::|:.:.|.::   ||
Mosquito  1356 ASRMDSTGLMDHIQVTEDVYQIVKDKGYNLTCRGTVNVKGKGTMITYLMPGLAK---EP 1411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	135/293 (46%)
		Guanylate_cyc	294..476	CDD:425528	103/181 (57%)
		Guanylate_cyc	892..1092	CDD:425528	103/199 (52%)
LOC1272957	XP_061519369.1	None