Protein Alignment Ac3 and Ac13E

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_061516135.1
• Gene: Ac13E / 1272181
• VectorBaseID: AGAMI1_002114
• Length: 1689
• Species: Anopheles gambiae
• Alignment Length: 1642
• Identity: 370/1642 - (22%)
• Similarity: 563/1642 - (34%)
• Gaps: 708/1642 - (43%)

  Fly    74 VFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFH------QILL 132
            :|..||..:|.......::....:.:||.:|..|....||.:.|.:..| |..|.      .::.
Mosquito   133 IFLFALAGLWVTRTDLYRAHTHLLSSCCAVLLCLFSLCLLLLTREALSP-LGHFSICIEIVMLIY 196

  Fly   133 IIVPRALWL--------------LSILHFTVYVIL-----QPSFSPRDLLGWAILLNFLVYVTLP 178
            .|:|..|||              ||.||.|.|...     ||:.||
Mosquito   197 TIIPLPLWLCCTITMAYSVCFEVLSFLHQTHYDYNSRPGGQPTVSP------------------- 242

  Fly   179 LQLIFLGLSIGCITYFICLSLPVG------------YSH--------WDSLLSNQLAANAVLIAT 223
                   |:.|..|....|:..|.            :.|        .||.:...:....::...
Mosquito   243 -------LAAGITTAARLLAEEVAIAGSDQQQQHHHHQHHHHHHHQTGDSFVYKIVLIRVLIQLC 300

  Fly   224 AALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLG---- 284
            ..|||:....|...:.:..|::..::|.|:..:|.:...:|:::.|::|..||..:.::.|
Mosquito   301 VHLIGIQILIMTVVRMRGTFMKVGQNLLVRRQLEMEKQLKEKMIHSMMPPKVADLLLKESGSVPK 365

  Fly   285 -----------------SSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELF 332
                             |.....|:..:|:|.||||||:|||||||.:|||.:|:.||::||:||
Mosquito   366 GTSFDQYPAPGGRRTTPSDLKSLFRPFHMNRMENVSILFADIVGFTRMSSTKTAEQLVEILNDLF 430

  Fly   333 ARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRV 397
            .|||.|.......:|..|||||||:||.|:.|||||:.||.|||.|:::|:....:.|..:.|||
Mosquito   431 ERFDDLCLVNGCEKISTLGDCYYCVSGCPEPRPDHAICCVEMGLGMIESIRVFDAQRNEGIKMRV 495

  Fly   398 GIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKR 462
            |:|||.||.||:|.::.:|||:|.||.|||:||||||..:||:|::|..||...:.:|.  ||:
Mosquito   496 GVHTGTVLCGIVGTKRVKFDVWSNDVTLANRMESSGKPDQVHVSEETCGFLGDSYIIEE--GEE- 557

  Fly   463 EELLRIAGLKTYF-----------ITKVVKAFASP------------------------------ 486
                 :.|.:|||           ||:.:.:...|
Mosquito   558 -----VDGHRTYFVLGKRLDLVGSITEGLSSIGLPVDLNLLGASSPSPLDELRDYATSEEHPESS 617

  Fly   487 C----AKKINETQAEIAHPNPNG------------------------------------------ 505
            |    |..::..|..:...:|.|
Mosquito   618 CLSRSATNLSSIQPAVPPASPAGPVFFSSLHASPVSTPRPRIASLTKMTKFLRSAVSKGDGGGRL 682

  Fly   506 ---------------------STTDIV----SDEDDND-----ATLDDEELL------------- 527
                                 ||..|.    ||:||:|     ...:|:||:
Mosquito   683 LNAGRTPPAPPPVVEKPKIIISTKSISNGFDSDDDDDDRGGGGGCNEDDELVGMGGGAGRGRARS 747

  Fly   528 ----------------------------------------------------------------- 527
                                                                             
Mosquito   748 PASPRQSMTQEAPPTTLAMLNERRKQEGGGEAGVGQRKPPGRVLKVGAPEPDCGRICDSSKSCDD 812

  Fly   528 -----------AQNSVSNGHQI------------------------------------------- 538
                       :.||.||...|
Mosquito   813 DVPCIERMGSSSSNSASNNQNITNGCYQHVPIVIVTPRPSCHTLDVANGGTPAPPASGAPTASGS 877

  Fly   539 ---------GIAVTADE----------EEQVKLENFKQRLKDEL--------------------- 563
                     |...|..|          :|.:.:.::..:.:.::
Mosquito   878 CSAARSRDCGKGPTVGENPHASQGSVFDEIIDVRSYISQSRSDISPFARTGSYRSQADRSSIIHE 942

  Fly   564 -----------------------VTRDGHENLT-------------------------------- 573
                                   :|...|...:
Mosquito   943 IALSAGAPGGSNSGTFGRPRSSTITTTHHHTCSEAHQHVRHGSVVVCPSSSRLLGADGASLSPSA 1007

  Fly   574 ---KDTNIFLRFKNPQLE-QL--------YAVYR------------------------------- 595
               ||:.|....:...:: ||        .:|:|
Mosquito  1008 TSRKDSGIRSNSRRSSIQHQLMLMSQTVALSVHRVSGYFTSSQSSLSGAIVTSAAGVPRAHKPNG 1072

  Fly   596 -------------------------------EPYSSLPLLAAL----------LVQCI----DVL 615
                                           ||:.. ||.|.|          |::|:    ...
Mosquito  1073 SMRAGTIATAANSGGAAAAAAPGSRCCMGLKEPHPD-PLAACLQQLRKQSDLQLIRCVRDNARSQ 1136

  Fly   616 YSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRF----NDITFVRELAA 676
            .||||.|           ||:||::       ...|..:.:.|...:.||    .|:.   |..:
Mosquito  1137 RSYLVKP-----------PLLPISL-------RFKSRPMEQEFRSKAHRFGSEGGDLL---EGGS 1180

  Fly   677 IIIALTIGFSNVIDMFF-FVTFVRTEHIVSESEFNVTAS--LESDINLVVEGMVTAEHLLPASFV 738
            .....|..::..|||.. ||.::.|    |.|.|.::.|  |||....|...:..:...|.|.|:
Mosquito  1181 PPTLATPKYNTYIDMLVSFVVYLAT----STSLFLLSPSVYLESYKVWVCIFVFFSTVQLFALFI 1241

  Fly   739 --EQM--RDAVPTER-------------------VLYP--------------SYLSNF------- 759
              :|:  |...||.|                   ..||              |.||||
Mosquito  1242 CTKQVCRRTRKPTVRRSRPVATRSCYDCLLQLASAWYPWHICGGILMSLPVISILSNFAMMDVTK 1306

  Fly   760 --------GVLILIAIAVIAQLTHLT----KILLLLSIAALHCYFNIFI--MQDLYALEDDFEHQ 810
                    |.|:.|.|......|.|.    ..:..::.||   :..|.:  |.:|.|||
Mosquito  1307 FRVFEFHYGFLMYICIVHFCNFTQLNWWMRNAMACITSAA---FVGIAVGHMVELQALE------ 1362

  Fly   811 PIISTRYA---------ASGLLLVAA---------------------------------LALSTL 833
              ::|..|         |:|..|:||                                 |.|..|
Mosquito  1363 --VATAAAAAAAAATLGANGTALLAAGGGGGDGAGGNEMLHRAQFDWFNNYRVEIYVDLLLLLVL 1425

  Fly   834 ARHMDHEDRVIFKWK---TEVAEQ-KETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYS 894
            ...::.|..:.::..   :.||.| |....:|:.:.:.|::|::|.||||. :|||.:     ||
Mosquito  1426 VWFLNREFEIGYRLSFHGSAVANQDKIRVQNMKNQADMLLHNIIPKHVAEQ-LKNTAK-----YS 1484

  Fly   895 QSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTY 959
            :::..:|::|||:.||::.|.|..:.  |.|.||.|||:|.|||.||..|:|:.:.||||||||:
Mosquito  1485 ENHHNIGIIFASIVNFNEMYDESYLG--GKEYLRVLNELIGDFDELLARPEFRCVEKIKTIGSTF 1547

  Fly   960 MAASGINVQRTVRNDAPIT--ERWSHLAILVEFALELKHALQSINEQ--SFNHFVLKMGINHGPI 1020
            |||||::         |.:  |.:.||..|::|||.::..::|.|..  .|| .::::|.|.|.:
Mosquito  1548 MAASGLD---------PSSRGETYEHLYTLLDFALAMQQVVESFNRDLLEFN-LIMRVGYNFGDV 1602

  Fly  1021 TAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFG--YTFLQRGLVAVKGKG 1083
            ||||||..|.:|||||:.|||||||:|||.||.:||..:...:|   |  |.|..||.|.||||.
Mosquito  1603 TAGVIGTSKLYYDIWGDAVNVASRMDSTGVAGRVQVGADCIPVL---GERYDFQPRGKVYVKGKD 1664

  Fly  1084 QLMTFYLQGKSQSSAEP 1100
            .:..:.|.||......|
Mosquito  1665 HMEVYLLVGKKPDLLGP 1681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	128/398 (32%)
		Guanylate_cyc	294..476	CDD:425528	93/192 (48%)
		Guanylate_cyc	892..1092	CDD:425528	91/205 (44%)
Ac13E	XP_061516135.1	None