Protein Alignment Ac3 and Npr2

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_446290.1
• Gene: Npr2 / 116564
• RGDID: 620851
• Length: 1047
• Species: Rattus norvegicus
• Alignment Length: 1110
• Identity: 235/1110 - (21%)
• Similarity: 408/1110 - (36%)
• Gaps: 354/1110 - (31%)

  Fly   106 YLALTALLHIGRRSDKPALRRFHQILLIIVPRALW--LLSILHFTVYVILQPSFSPRDLLGWAIL 168
            :.|..|||::..|:|.    |.|...:..|..||.  .||:.| .||. .:|. .|.....:...
  Rat   162 WTARAALLYLDARTDD----RPHYFTIEGVFEALQGSNLSVQH-QVYT-REPG-GPEQATHFIRA 219

  Fly   169 LNFLVYVTLPLQL---IFL-----GLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAA 225
            ...:||:..||::   |.|     .|:.|...:|.   |.|   ..:||.:....|.
  Rat   220 NGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFY---LDV---FGESLRAGPTRAT-------- 270

  Fly   226 LIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAE----QERLLLSVLPKHVAIKMREDLGSS 286
              |..:......:|.:|..||.:::.|....|..:.|    |.|||         |:.|||.|..
  Rat   271 --GRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLL---------IRAREDFGVE 324

  Fly   287 SSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFAR----------FDRLAEK 341
            .:.:...:......:..:|||.::..| |....:.:|.::::.::..|          .|:..::
  Rat   325 LAPSLMNLIAGCFYDGILLYAQVLNET-IQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDR 388

  Fly   342 YQQLRIKILGD---------CYYC---------------ISGAP----------------DERPD 366
            .....:..:||         .:|.               :.|||                |:.|.
  Rat   389 ETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPL 453

  Fly   367 HAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQW---QF---DVYSKDVEL 425
            ..:..|.:|    ..|.::....:|.:..| .:.....||.:|.:.:|   ||   |.|.|
  Rat   454 STLAIVALG----TGITFIMFGVSSFLIFR-KLMLEKELASMLWRIRWEELQFGNSDRYHK---- 509

  Fly   426 ANKMESSGKAGRVHISDK-----TLAFLNGEFEVEAAFG-------------EKREELLR----- 467
                   |...|:.:|.:     :|...:|::::.|..|             :||.||.|
  Rat   510 -------GAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFE 567

  Fly   468 ---IAGLKTYFITKVVKAFASPCAKKINETQAEIAHPN--------PNGSTTDIVSDEDDNDATL 521
               :..::...:|:.:.|...|              ||        |.||..||:.::..|   |
  Rat   568 LKHMRDVQFNHLTRFIGACIDP--------------PNICIVTEYCPRGSLQDILENDSIN---L 615

  Fly   522 DDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDG---HENLTKDTNIFLRFK 583
            |   .:.:.|:.|....|:|.                |.:.:::..|   ..|...|:...|:..
  Rat   616 D---WMFRYSLINDLVKGMAF----------------LHNSIISSHGSLKSSNCVVDSRFVLKIT 661

  Fly   584 NPQLEQLYAVYR---EPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVIS 645
            :..|    |.:|   ||..|..|.|..|                      ..||
  Rat   662 DYGL----ASFRSTAEPDDSHALYAKKL----------------------WTAP----------- 689

  Fly   646 LAESFSG-MLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEF 709
              |..|| .||                          |.|.... |::.|...:: |..:....|
  Rat   690 --ELLSGNPLP--------------------------TTGMQKA-DVYSFAIILQ-EIALRSGPF 724

  Fly   710 NVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLY-PSYLSNFGVLILIAIAVIAQL 773
                        .:||:    .|.|...|:::|:.   :|..: ||                ...
  Rat   725 ------------YLEGL----DLSPKEIVQKVRNG---QRPYFRPS----------------IDR 754

  Fly   774 THLTKILLLLSIAALHCYFNIFIMQDLYALE----DDFEHQPIISTRYAASGLLLVAALALSTLA 834
            |.|.:.|:||             |:..:|.:    .||........|:...|...:....|..:.
  Rat   755 TQLNEELVLL-------------MERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRME 806

  Fly   835 RHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAE 899
            ::.::.:::       |.|:.:...:.:::.|||:|.:||..|||...:.     :.:.::::..
  Rat   807 QYANNLEKL-------VEERTQAYLEEKRKAEALLYQILPHSVAEQLKRG-----ETVQAEAFDS 859

  Fly   900 VGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASG 964
            |.:.|:.:..|:...:|.|    .::.:..||::.:.|||:::  .| |:.|::|||..||..||
  Rat   860 VTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAIID--NF-DVYKVETIGDAYMVVSG 917

  Fly   965 I---NVQRTVRNDAPITERWSHLAILVEFALELKHALQS--INEQSFNHFVLKMGINHGPITAGV 1024
            :   |.||             |...:...||.|..|:.|  |..:..:...|::|::.||:.|||
  Rat   918 LPGRNGQR-------------HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGV 969

  Fly  1025 IGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQ-RGLVAVKGKGQLMTF 1088
            :|.:.|.|.::|:|||.||||||.|:|..|.|:..|.:.|...|...|: ||.|.:||||::.|:
  Rat   970 VGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTY 1034

  Fly  1089 YLQGK 1093
            :|.|:
  Rat  1035 WLLGE 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	41/171 (24%)
		CYCc	256..453	CDD:214485	46/261 (18%)
		Guanylate_cyc	294..476	CDD:278633	42/263 (16%)
		CYCc	860..1071	CDD:214485	66/215 (31%)
		Guanylate_cyc	892..1092	CDD:278633	67/205 (33%)
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607	60/291 (21%)
		PK_GC-A_B	518..792	CDD:270944	73/424 (17%)
		HNOBA	<798..846	CDD:400168	12/54 (22%)
		CYCc	825..1009	CDD:214485	64/208 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810