DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac3 and Gucy2f

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_446283.1 Gene:Gucy2f / 116556 RGDID:620439 Length:1108 Species:Rattus norvegicus


Alignment Length:535 Identity:129/535 - (24%)
Similarity:206/535 - (38%) Gaps:158/535 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   665 FNDITFVRELAAIIIAL-----------TIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLE-- 716
            |.||..::..|:.:..:           .:||.....||..|           |||....|||  
  Rat   581 FGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIV-----------SEFCSRRSLEDI 634

  Fly   717 ---SDINL-----------VVEGMVTAEH-------------LLPASFV------------EQMR 742
               .|:.|           :::||....|             ::...||            |.:|
  Rat   635 LTQDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNNILEMLR 699

  Fly   743 --DAVPTERVLY---PSYLSNFGVLIL-------IAIAVIAQLTHLTKILLLLSIAALHCYFNIF 795
              :..|:|..|.   |..|...|.:.|       .:.|:|.|     ::::.   .|..|     
  Rat   700 LSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQ-----EVMVR---GAPFC----- 751

  Fly   796 IMQDLYALE--DDFE-----HQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKT---- 849
             |.||.|.|  |..:     ::|::|..:|....|.:.....:..|......|.:..::||    
  Rat   752 -MMDLSAKEVIDRLKMPPPVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKG 815

  Fly   850 ----------------------EVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDL 892
                                  .:.|:.|.....:|:.|.|:..:||..|||...|......:..
  Rat   816 KKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF 880

  Fly   893 YSQSYAEVGVLFASMPNFSDFYSEETVN--NQGLECLRFLNEVISDFDALLELPQFQDIIKIKTI 955
                  ::..|:     |||.....|::  ::.:|.:..||::.:.|||::   ...|:.|::||
  Rat   881 ------DLVTLY-----FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAII---GSHDVYKVETI 931

  Fly   956 GSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFV-----LKMGI 1015
            |..||.|||:..:...|          |.|.:...:|::   |.|:......|..     :::|:
  Rat   932 GDAYMVASGLPKRNGSR----------HAAEIANMSLDI---LSSVGTFKMRHMPEVPVRIRIGL 983

  Fly  1016 NHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLF--GYTFLQRGLVA 1078
            :.||:.|||:|...|.|.::|:|||.||||||||....|.|:..|..|||..  ||....||...
  Rat   984 HTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILRTLSEGYEVELRGRTE 1048

  Fly  1079 VKGKGQLMTFYLQGK 1093
            :||||...||:|.||
  Rat  1049 LKGKGTEETFWLVGK 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831
CYCc 256..453 CDD:214485
Guanylate_cyc 294..476 CDD:278633
CYCc 860..1071 CDD:214485 66/219 (30%)
Guanylate_cyc 892..1092 CDD:278633 66/208 (32%)
Gucy2fNP_446283.1 PBP1_sensory_GC_DEF_like 54..435 CDD:107366
ANF_receptor 75..412 CDD:279440
PKc_like 545..815 CDD:304357 50/258 (19%)
TyrKc 565..809 CDD:197581 48/252 (19%)
HNOBA <824..869 CDD:285003 10/44 (23%)
CYCc 848..1040 CDD:214485 65/218 (30%)
Guanylate_cyc 875..1062 CDD:278633 66/213 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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