Protein Alignment Ac3 and Adcy9

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001400201.1
• Gene: Adcy9 / 11515
• MGIID: 108450
• Length: 1372
• Species: Mus musculus
• Alignment Length: 1306
• Identity: 366/1306 - (28%)
• Similarity: 536/1306 - (41%)
• Gaps: 368/1306 - (28%)

  Fly    70 LKWFVFA---AALFNIWT-IGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQI 130
            |...|||   ||.|.:|| :....|.|..|       |.|..|.|.|..:|..|
Mouse   179 LTLLVFALTLAAQFQVWTPLSGRVDSSNHT-------LTATPADTCLSQVGSFS----------- 225

  Fly   131 LLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL-IFLGLSIGCITYF 194
               |....|.||       |.::|                      |||.| :|||     :.|.
Mouse   226 ---ICIEVLLLL-------YTVMQ----------------------LPLYLSLFLG-----VVYS 253

  Fly   195 I-------------CLSLP-VGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLE 245
            :             |...| .|..||      :|.:.|:|......||:..:.|.:.:.:..||:
Mouse   254 VLFETFGYHFRNEDCYPSPGPGALHW------ELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLK 312

  Fly   246 AKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL---GSSSSE------------------ 289
            ..:|:.....:|.:.|.:||::.||:|:.:|    :||   |...||
Mouse   313 VGQSIMHGKDLEVEKALKERMIHSVMPRIIA----DDLMKQGDEESENSVKRHATSSPKNRKKKS 373

  Fly   290 -------AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRI 347
                   ||:...|.:.|.||||:|||||||.:|:..||..||.:||:||.|||||.|:.:..:|
Mouse   374 SIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKI 438

  Fly   348 KILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQR 412
            ..|||||||::|.|:.|.|||..|:.|||.|:|||:...|:....|:||||:|||.||.||||.|
Mouse   439 STLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMR 503

  Fly   413 QWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREEL------LRIAGL 471
            :::|||:|.||.|||.||..|.||:||||:.|..:|:..:|:|.  |...|.|      .::.||
Mouse   504 RFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMED--GRVIERLGQSVVADQLKGL 566

  Fly   472 KTYFIT-KVVKAFASPCAKKI-------------------------------------------- 491
            |||.|: :..|.....||:.:
Mouse   567 KTYLISGQRAKESHCSCAEALLSGFEVIDDSRESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCP 631

  Fly   492 ---------NETQAE------------------------------IAHP-----NPNGSTTDIVS 512
                     :|..||                              :|||     .||..|.:.:.
Mouse   632 SCGITFAPKSEAGAEGGTVQNGCQDEPKTSTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLL 696

  Fly   513 DEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKD-- 575
            .....:...:.:..|.:.....|...|:::.......::.:|.:::.....|.....::|.||
Mouse   697 SPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYF 761

  Fly   576 ----TNIF-LRFKNPQLEQLY--AVYREPYSSLPL---LAALLVQCIDVLYS---YLVLPRST-L 626
                .|.| |.|.:.:||:.|  :...|...:.|:   .:|.....:||..|   :|:|..:. |
Mouse   762 FKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITCFL 826

  Fly   627 HFINIAAPLVPIAMLV------------VIS----------------LAESFSGMLPKFFVDVSK 663
            .:...|.|..|.|:.|            ::|                |.|..:|.||:..:
Mouse   827 KYGATATPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVMTCTKWLLEWIAGWLPRHCI---- 887

  Fly   664 RFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVT 728
                       .||:::|.             ......||.||.|.|:..:           |.|
Mouse   888 -----------GAILVSLP-------------ALAVYSHITSEFETNIHVT-----------MFT 917

  Fly   729 AEHLLPA-----SFVE---QMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSI 785
            ...:|.|     :|.:   .||.::.|        :...|:|:|:.|::
Mouse   918 GSAVLVAVVHYCNFCQLSSWMRSSLAT--------IVGAGLLLLLHISL---------------- 958

  Fly   786 AALHCYFNIFIMQDL---------------YALEDDFEHQPIISTRYAASGLLLVAALALSTLAR 835
                |..:..:|..|               ..|:|......:|......:..||:  |.:..|.|
Mouse   959 ----CQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLL--LLVWFLNR 1017

  Fly   836 HMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEV 900
            ..:...|:.:....|....:.....||.:.:.|:.|::|.||||....:      ..||:::...
Mouse  1018 EFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVS------QTYSKNHDSG 1076

  Fly   901 GVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGI 965
            ||:|||:.|||:||.|.  ...|.||.|.|||:|.|||.||..|.:..|.||||||:|||||||:
Mouse  1077 GVIFASIVNFSEFYEEN--YEGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASGL 1139

  Fly   966 NVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQS--FNHFVLKMGINHGPITAGVIGAR 1028
            |..:......|    ..||.||.|||.|:...:...|...  || |.|::|.||||:||||||..
Mouse  1140 NTAQCQEGGHP----QEHLRILFEFAKEMMRVVDDFNNNMLWFN-FKLRVGFNHGPLTAGVIGTT 1199

  Fly  1029 KPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGK 1093
            |..|||||:|||:||||::||....|||:||:..:|...||.|..||.|.||||||:.| ||..|
Mouse  1200 KLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT-YLYPK 1263

  Fly  1094 SQSSAEPVASGVVVLNGQDSSAVESTSELEASDIKMPLLKMNGPEQSLEIDQDRSLRNDSAGQES 1158
            ...:.       ||...|.|.:.:...:::.|..:.|..::.....|::.....||.:|.:.|..
Mouse  1264 CTDNG-------VVPQHQLSISPDIRVQVDGSIGRSPTDEIANLVPSVQYSDKASLGSDDSTQAK 1321

  Fly  1159 VAECQS 1164
            .|...|
Mouse  1322 EARLSS 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	130/375 (35%)
		Guanylate_cyc	294..476	CDD:425528	96/187 (51%)
		Guanylate_cyc	892..1092	CDD:425528	103/201 (51%)
Adcy9	NP_001400201.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..73
		AcyC	167..576	CDD:441717	159/463 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..375		3/25 (12%)
		Guanylate_cyc	385..573	CDD:425528	97/189 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..615		0/18 (0%)
		Guanylate_cyc	1069..1260	CDD:425528	101/198 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1309..1333		6/19 (32%)