DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ac3 and Adcy8

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_033753.2 Gene:Adcy8 / 11514 MGIID:1341110 Length:1249 Species:Mus musculus


Alignment Length:1210 Identity:398/1210 - (32%)
Similarity:619/1210 - (51%) Gaps:192/1210 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 NDSDVAGGVGITGGGVVILP-------QHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTI--- 85
            :|..:.||....|   ||.|       ...|..||..|.:.|||.       :..:.|:..:   
Mouse   137 SDFFLNGGYSYRG---VIFPTLRNSFKSRDLERLYQRYFLGQRRK-------SEVVMNVLDVLTK 191

  Fly    86 -----------GIPWDQSAPTRVINCCMLLAY-----LALTALLHIGRRSDKPALRRFHQILLII 134
                       ..|.|   |.:.|    ||.:     :.:.||:.:.:.:......::..::..:
Mouse   192 LTLLVLHLSLASAPMD---PLKGI----LLGFFTGIEVVICALVVVRKDNTSHTYLQYSGVVTWV 249

  Fly   135 VPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIF-----LGLSIGCITYF 194
            ......|.:.|.:.:.         .|.:|:.:...|..|..|||.|.:     ||.|:..:|..
Mouse   250 AMTTQILAAGLGYGLL---------GDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQ 305

  Fly   195 ICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQ 259
            :.:.....:|      .||:.|..||.......|:...::.:..|::||||.::.:|.::.:|.:
Mouse   306 VLIPRLAVFS------INQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETE 364

  Fly   260 SAEQERLLLSVLPKHVAIKMREDLGSSSSE----AFKKIYMSRHENVSILYADIVGFTAISSTYS 320
            :..||||:|||||:.|.::|..|:.:...|    .|.:||:.|:||||||:||:.|||.:|:|.|
Mouse   365 NQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLS 429

  Fly   321 AQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYV 385
            ||:||:|||||||||||||.::..||||||||||||:||.|:.|.|||..||.|||||:|.|::|
Mouse   430 AQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFV 494

  Fly   386 QQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNG 450
            :.:....||||:|||:|:||.|:||.|:|||||:|.||::|||:||.|..||:|||..||..|||
Mouse   495 RSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNG 559

  Fly   451 EFEVEAAFGEKREELLRIAGLKTYFITK-----------VVKAFASPCAKKINE----TQA---- 496
            ::.||...|::|.|.||...::||.|.:           :||...| |:.:.|.    |:.    
Mouse   560 DYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVS-CSDRRNSGATFTEGSWSP 623

  Fly   497 EIAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVS---NGHQIGIAVTADEEEQVKLENFKQR 558
            |:...|..|....:.:              |.:||::   |.....:.|.:..||      ..:|
Mouse   624 ELPFDNIVGKQNTLAA--------------LTRNSINLLPNHLAQALHVQSGPEE------INKR 668

  Fly   559 LKDELVTRDGHENLTKDTNIF-LRFKNPQLEQLYAVYR-EPYSSLPLLAALLVQCIDVLYSYLVL 621
            ::..:..|.|.:...:....| |.||:..||..|:..| |.:.|..:.|.:::..|..:.|  :|
Mouse   669 IEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQS--LL 731

  Fly   622 PRSTLHFINIAAPLVPI--AMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIG 684
            |.|.|..:.|...::.:  :.||:|:.||.:. .||..........|: |::.....|..::.|.
Mouse   732 PSSRLMPMTIQFSILIMLHSALVLITTAEDYK-CLPLILRKTCCWINE-TYLARNVIIFASILIN 794

  Fly   685 FSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTER 749
            |...:....:..|.::                                :|...:.....||.|:.
Mouse   795 FLGAVLNILWCDFDKS--------------------------------IPLKNLTFNSSAVFTDI 827

  Fly   750 VLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEH--QPI 812
            ..||.|....|||.::..||..:|..:.|:.:||.:.|::......|...|:...|:..|  :..
Mouse   828 CSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDF 892

  Fly   813 ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHV 877
            :.|:.|:..|:.:..||:....:.:::..|:.|.|:.:..|:.....::|:.||.::.|:||.||
Mouse   893 LGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV 957

  Fly   878 AEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLE 942
            |.||::. .|.:::||||||..|||:|||:|.|:||||:..:||||:||||.|||:|:|||.||.
Mouse   958 ARHFLEK-DRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLG 1021

  Fly   943 LPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFN 1007
            ..:||||.|||||||||||.||::.::....|     :|.||..|.:|:|.|..::|.||:.|||
Mouse  1022 EDRFQDIEKIKTIGSTYMAVSGLSPEKQQCED-----KWGHLCALADFSLALTESIQEINKHSFN 1081

  Fly  1008 HFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFL 1072
            :|.|::||:||.:.||||||:||.|||||.|||:||||:|||.:|.|||.|||..||:..|:.|.
Mouse  1082 NFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFD 1146

  Fly  1073 QRGLVAVKG----KGQLMTFYLQGK--------------SQSSAEPVASGVV----------VLN 1109
            .||.:.|||    :|::.|::|.|:              .|.|...|..|:|          :||
Mouse  1147 YRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLN 1211

  Fly  1110 GQDSSAVESTSELEASDIKMPLLKMNGPEQSLEID-QDRS 1148
            ...:|.:     :::...:..||..:|||...:.: .|:|
Mouse  1212 ENSNSGI-----IKSHYNRRTLLTPSGPEPGAQAEGTDKS 1246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 40/162 (25%)
CYCc 256..453 CDD:214485 116/200 (58%)
Guanylate_cyc 294..476 CDD:278633 110/181 (61%)
CYCc 860..1071 CDD:214485 117/210 (56%)
Guanylate_cyc 892..1092 CDD:278633 114/203 (56%)
Adcy8NP_033753.2 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..180 14/52 (27%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..33
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..118
AC_N <159..398 CDD:292831 57/267 (21%)
CYCc 364..562 CDD:214485 115/197 (58%)
Guanylate_cyc 403..587 CDD:278633 111/183 (61%)
DUF1053 615..709 CDD:283888 22/113 (19%)
CYCc 942..1146 CDD:214485 117/209 (56%)
Guanylate_cyc 971..1170 CDD:278633 114/203 (56%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1107..1249 49/145 (34%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1198..1213 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1249 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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