Protein Alignment Ac3 and Adcy7

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1170
• Identity: 373/1170 - (31%)
• Similarity: 557/1170 - (47%)
• Gaps: 228/1170 - (19%)

  Fly   102 MLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYV--ILQPSFSPRDLLG 164
            :||...|.|.:..|........||| ||::|......|.|...|:..|||  ::|.......||.
Mouse    37 LLLLVAAATCIALISIAFSHEDLRR-HQVVLGTAFLMLTLFVALYVLVYVECLVQRWLRALALLT 100

  Fly   165 WAILL---------------------------NFLVYVTLPLQ---LIFLG--------LSIGCI 191
            ||.|:                           .|:||..|||.   .|..|        |..|.:
Mouse   101 WACLMVLGSVLMWDSLENEAHAWEQVPFFLFVVFVVYALLPLSRRAAIVAGVTSTVSHLLVFGAV 165

  Fly   192 TYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVI 256
            |.....|:.      .:.|..||.||||::......|..:....:...:..|:...|.::::..:
Mouse   166 TRAFQTSMS------STQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKL 224

  Fly   257 EEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEA----------FKKIYMSRHENVSILYADIVG 311
            ..:..:||.|||||||.|:::.|:..:.....|.          |..:|:.||:|||||||||||
Mouse   225 RVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKRHQNVSILYADIVG 289

  Fly   312 FTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGL 376
            ||.::|..|.::||.:|||||.:||::|:..:.:|||||||||||:||.|...|.||..||.|||
Mouse   290 FTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGL 354

  Fly   377 SMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHIS 441
            .:.:|||.|::.....:.||||||:|.||.|::|.|:||:||:|.||.|||:||::|..|||||:
Mouse   355 DICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHIT 419

  Fly   442 DKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAE--------- 497
            :.||..|:..:|||...||:|:..|:...::||.:.........|.:..:::.:.:
Mouse   420 EATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASV 484

  Fly   498 --------------IAHPNPNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEE 548
                          .||.|...|.:.                  ::..:|||.:         ::
Mouse   485 RVTRYLESWGAARPFAHLNHRESVSS------------------SETPISNGRR---------QK 522

  Fly   549 QVKLENF---------KQRLKDE-----LVTRDGHEN---LTKDTNIFLRFKNPQLEQLYAVYRE 596
            .:.|...         |.||:|:     |...:|..:   ....::.|..|....||:   .:..
Mouse   523 AIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEK---GFER 584

  Fly   597 PYSSLPL--------LAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVIS--LAESFS 651
            .|..:|:        .|:|:..|| :|...||:||  :..:.::..||...:.:|:|  .|..||
Mouse   585 EYRLVPIPRARYDFACASLVFVCI-LLVHLLVMPR--MATLGVSFGLVACLLGLVLSFCFATEFS 646

  Fly   652 GMLP--KFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTAS 714
            ...|  .....:|:.......||   .:::.||:|                 .:::.:..|:..:
Mouse   647 RCFPSRSTLQAISESVETQPLVR---LVLVVLTVG-----------------SLLTVAIINMPLT 691

  Fly   715 LESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLT-HLTK 778
            |.       .|.........:....|.|...|.|  |.|.|..:. :|..||.:|..::: .|..
Mouse   692 LN-------PGPEQPGDNKTSPLAAQNRVGTPCE--LLPYYTCSC-ILGFIACSVFLRMSLELKA 746

  Fly   779 ILLLLSIAALHCYFNI--------------------FIMQDLYA-------------------LE 804
            :||.:::.|....||:                    .::.|..:                   ||
Mouse   747 MLLTVALVAYLLLFNLSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLE 811

  Fly   805 DDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALV 869
            .|.:   |:...|.   :|..|.|.|  |:|.:|:..|:...||.:..::.|....|...|..|:
Mouse   812 RDLK---IMVNFYL---ILFYATLIL--LSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLL 868

  Fly   870 YNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVI 934
            .||||.|||.||:.:  ::.:|.|.|||..|.|:|||:|:|..||:|..||.:||||||.|||:|
Mouse   869 ENVLPAHVAAHFIGD--KAAEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEII 931

  Fly   935 SDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQ 999
            :|||.||..|:|..:.||||||||||||:|::......|. .:..:..|:.:||||::.|...|.
Mouse   932 ADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSAPSGHENQ-DLERKHVHIGVLVEFSMALMSKLD 995

  Fly  1000 SINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNIL 1064
            .||..|||.|.|::||||||:.|||||||||.||||||||||||||||||:.|.||||||||.||
Mouse   996 GINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTIL 1060

  Fly  1065 RLFGYTFLQRGLVAVKGKGQLMTFY-LQGKSQSSAEPVASGVVVLNGQDSSAVESTSELEASDIK 1128
            :..||:...|||:.|||||:|.|:: |...:.|..:...||.::..    .::.:.|...:||:|
Mouse  1061 QGLGYSCECRGLINVKGKGELRTYFELFFLNPSVGQGFVSGSLLRR----PSLTTDSNTPSSDLK 1121

  Fly  1129  1128
            Mouse  1122  1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	141/382 (37%)
		Guanylate_cyc	294..476	CDD:425528	96/181 (53%)
		Guanylate_cyc	892..1092	CDD:425528	118/200 (59%)
Adcy7	XP_006530643.1	AcyC	48..456	CDD:441717	150/414 (36%)
		Guanylate_cyc	272..422	CDD:425528	84/149 (56%)
		Adcy_cons_dom	487..594	CDD:461877	20/136 (15%)
		Guanylate_cyc	890..1085	CDD:425528	117/195 (60%)