Protein Alignment Ac3 and Adcy6

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_006520366.3
• Gene: Adcy6 / 11512
• MGIID: 87917
• Length: 1254
• Species: Mus musculus
• Alignment Length: 1141
• Identity: 382/1141 - (33%)
• Similarity: 574/1141 - (50%)
• Gaps: 191/1141 - (16%)

  Fly    55 NELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRRS 119
            :.|...:..||.||.....::....|.:       :||:.|.::...:||..:.||  .|.....
Mouse   206 HRLVQVFQSKQFRSAKLERLYQRYFFQM-------NQSSLTLLMAVLVLLMAVLLT--FHAAPAQ 261

  Fly   120 DKPA-------LRRFHQILLIIVPR------ALWLLSILHFTVYVILQPSFSPRDLLGWAILLN- 170
            .:||       ......:|:::..|      ::|::|.:...:...:|        :|.|:..|
Mouse   262 PQPAYVALLTCASVLFVVLMVVCNRHSFRQDSMWVVSYVVLGILAAVQ--------VGGALAANP 318

  Fly   171 -----------FLVYVT---LPLQLIFLGLS-IGCITYFICLSLPVGYSHWDSLLSNQLAANAVL 220
                       |.||:|   ||:::....|| :|..|..:.|:..:..|  |..|..||.||.||
Mouse   319 HSPSAGLWCPVFFVYITYTLLPIRMRAAVLSGLGLSTLHLILAWQLNSS--DPFLWKQLGANVVL 381

  Fly   221 IATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGS 285
            ......||:..::..|..|::||.|.:..::.::.::.::.:||||||||||:|||::|:||:.:
Mouse   382 FLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINT 446

  Fly   286 SSSE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKI 349
            ...: .|.|||:.:|:|||||:|||.|||:::|..:||:||..|||||||||:||.:...|||||
Mouse   447 KKEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKI 511

  Fly   350 LGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQW 414
            |||||||:||.|:.|.|||..||.||:.|::||..|::.....|:||||||:|.|..|:||.|:|
Mouse   512 LGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKW 576

  Fly   415 QFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI--- 476
            ||||:|.||.|||.||:.|:|||:||:..||.:|||::|||...|.:|...|:...::|:.|
Mouse   577 QFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQCIETFLILGA 641

  Fly   477 ---TKVVKAFASPCAKKINETQAEIAH-----------------------------PNPNGSTTD 509
               .|..||..:    |:..|:|....                             ...|....|
Mouse   642 SQKRKEEKAMLA----KLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQD 702

  Fly   510 IVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTK 574
            .::.||:.|..|                 |.|:.|...:|::.::.::.|
Mouse   703 ALNPEDEVDEFL-----------------GRAIDARSIDQLRKDHVRRFL--------------- 735

  Fly   575 DTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIA 639
                 |.|:...||:.|:...:|.....:..||||.|.......||.|.|||.....||..:.:.
Mouse   736 -----LTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLVFPYSTLILGIYAAIFLLLL 795

  Fly   640 MLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFF-VTFVRTEHI 703
            :.|:|....|.....||....:|:.............|...|.:..|.:.:||.. .|.:||
Mouse   796 VTVLICAVCSCGSFFPKALQRLSRNIVRSRVHSTAVGIFSVLLVFISAIANMFTCNHTPIRT--- 857

  Fly   704 VSESEFNVTASLESDINLVVEGMVTAEHL--------LPASFVEQMRDAVPTERVLYPSYLSNFG 760
            .:....|:|.:           .|||.||        |.|...|   ...||  ..:|.|.....
Mouse   858 CAARMLNLTPA-----------DVTACHLQQLNYSLGLDAPLCE---GTAPT--CSFPEYFVGNV 906

  Fly   761 VLILIAIAVIAQLTHLTK------------ILLLLS-IAALHCYFNIFI-MQDLYALEDDFEHQP 811
            :|.|:|.:|...::.:.|            :||||. .||:...:::.: :..|.:..:.|:...
Mouse   907 LLSLLASSVFLHISSIGKLAMTFILGFTYLVLLLLGPPAAIFDNYDLLLGVHGLASSNETFDGLD 971

  Fly   812 I-----ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYN 871
            .     ::.:|....:|||.||||...|:.::...|:.|.||.:...:||...:::..|..|::|
Mouse   972 CPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHN 1036

  Fly   872 VLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISD 936
            :||..||.||:...:| :|:||.||...|.|:|||:.|||:||.|...||:|:||||.|||:|:|
Mouse  1037 ILPKDVAAHFLARERR-NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIAD 1100

  Fly   937 FDALLELPQFQDIIKIKTIGSTYMAASGIN------VQRTVRNDAPITERWSHLAILVEFALELK 995
            ||.::...:|:.:.||||||||||||||:|      |.|            ||:..|.::|:.|.
Mouse  1101 FDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR------------SHITALADYAMRLM 1153

  Fly   996 HALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEET 1060
            ..::.|||.|||:|.:|:|:|.||:.|||||||||.||||||||||:|||:|||....||||.:.
Mouse  1154 EQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDL 1218

  Fly  1061 CNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQS 1096
            ..:|...||....||:|.|||||::.|::|.|...|
Mouse  1219 YQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	150/362 (41%)
		Guanylate_cyc	294..476	CDD:425528	101/181 (56%)
		Guanylate_cyc	892..1092	CDD:425528	106/205 (52%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	67/266 (25%)
		Guanylate_cyc	456..640	CDD:425528	102/183 (56%)
		Adcy_cons_dom	668..755	CDD:461877	17/123 (14%)
		Guanylate_cyc	1056..1250	CDD:425528	106/205 (52%)