Protein Alignment Ac3 and ADCY9

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1452
• Identity: 381/1452 - (26%)
• Similarity: 581/1452 - (40%)
• Gaps: 419/1452 - (28%)

  Fly    10 KTIASTSKSHSQRQTTSRRRQNDSDVAGGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWFV 74
            |.::|.|.....:.:.|....:..|..|.....|||..:..|..|.:|:       .|:..:|
Human    35 KQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLF-------ERASSRW-- 90

  Fly    75 FAAALFNIWTIGIPWDQSAPT-RVINCCM-------------LLAYLALTALL-------HIGRR 118
                          ||....: .:...|:             .|.|:....||       |:..|
Human    91 --------------WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSR 141

  Fly   119 SDKPALRRFHQILLIIVPRALWLLSILHFTVYV------------------------------IL 153
                       :::::.|...:||..:.|.::.                              :|
Human   142 -----------LIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLLVFALTLAAQFQVL 195

  Fly   154 QP------------SFSPRDL-------LGWAILLNFLVYVTLPLQLIFLGLSIGCITYFI---- 195
            .|            :..|.|.       ....|.:.||:|..:.|.| :|.|.:| :.|.:
Human   196 TPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPL-YLSLCLG-VAYSVLFET 258

  Fly   196 ---------CLSLP-VGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSL 250
                     |...| .|..||: |||..|....:     ..||:..:.|.:.:.:..||:..:|:
Human   259 FGYHFRDEACFPSPGAGALHWE-LLSRGLLHGCI-----HAIGVHLFVMSQVRSRSTFLKVGQSI 317

  Fly   251 EVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL---GSSSSE----------------------- 289
            .....:|.:.|.:||::.||:|:.:|    :||   |...||
Human   318 MHGKDLEVEKALKERMIHSVMPRIIA----DDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKA 378

  Fly   290 --AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGD 352
              ||:...|.:.|.||||:|||||||.:|:..||..||.:||:||.|||||.|:.:..:|..|||
Human   379 PIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGD 443

  Fly   353 CYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFD 417
            ||||::|.|:.|.|||..|:.|||.|:|||:...|:....|:||||:|||.||.||||.|:::||
Human   444 CYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFD 508

  Fly   418 VYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREEL------LRIAGLKTYFI 476
            |:|.||.|||.||..|.||:||||:.|..:|:..:|:|.  |:..|.|      .::.|||||.|
Human   509 VWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMED--GKVIERLGQSVVADQLKGLKTYLI 571

  Fly   477 T-KVVKAFASPCAKKI------------------------------------------------- 491
            : :..|.....||:.:
Human   572 SGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKTFDNLKTCPSCGIT 636

  Fly   492 ----NETQAE------------------------------IAHP-----NPNGSTTDIVSDEDDN 517
                :|..||                              :|||     .||..|.:.:......
Human   637 FAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQE 701

  Fly   518 DATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKD------T 576
            :...:.:..|.:.....|...|:::.......::.:|.:::.....|.....::|.||      .
Human   702 EKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPI 766

  Fly   577 NIF-LRFKNPQLEQLYAV-YRE------PYSSL--PLLAALLVQCIDVLYSYLV-LPRSTLHFIN 630
            |.| |.|.:.:||:.|.. |:|      |..:.  |..::||    ||..|..| |..||..|:.
Human   767 NQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSLL----DVFLSTTVFLTLSTTCFLK 827

  Fly   631 IAAPLVP-----------IAMLVVISLA--------------------ESFSGMLPKFFVDVSKR 664
            ..|..||           ..:|.|:|||                    |..:|.||:..:
Human   828 YEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLPRHCI----- 887

  Fly   665 FNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNV-----TASLESDINLVVE 724
                      .||:::|.             ......|:.||.|.|:     |.|         .
Human   888 ----------GAILVSLP-------------ALAVYSHVTSEYETNIHFPVFTGS---------A 920

  Fly   725 GMVTAEHLLPASFVE---QMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKIL-LLLSI 785
            .::...|.  .:|.:   .||.::.|        :...|.|:|:.:::....:.||..| .:.:.
Human   921 ALIAVVHY--CNFCQLSSWMRSSLAT--------VVGAGPLLLLYVSLCPDSSVLTSPLDAVQNF 975

  Fly   786 AALHCYFNIFIMQDLYALEDDFEHQP--IISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWK 848
            ::.....|..:.:||        .:|  :|.........||:  |.:..|.|..:...|:.:...
Human   976 SSERNPCNSSVPRDL--------RRPASLIGQEVVLVFFLLL--LLVWFLNREFEVSYRLHYHGD 1030

  Fly   849 TEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDF 913
            .|....:.....||.:.:.|:.|::|.||||....:      ..||:::...||:|||:.|||:|
Human  1031 VEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVS------QTYSKNHDSGGVIFASIVNFSEF 1089

  Fly   914 YSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPIT 978
            |.|.  ...|.||.|.|||:|.|||.||..|.:..|.||||||:|||||||:|..:......|
Human  1090 YEEN--YEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHP-- 1150

  Fly   979 ERWSHLAILVEFALELKHALQSINEQS--FNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNV 1041
              ..||.||.|||.|:...:...|...  || |.|::|.||||:||||||..|..|||||:|||:
Human  1151 --QEHLQILFEFAKEMMRVVDDFNNNMLWFN-FKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNI 1212

  Fly  1042 ASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGK------------- 1093
            ||||::||....|||:||:..:|...||.|..||.|.||||||:.| ||..|
Human  1213 ASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKT-YLYPKCTDHRVIPQHQLS 1276

  Fly  1094 -------------SQSSAEPVASGVVVLNGQDSSAVESTSELEASDIKM-PLLKMNGPEQSLEID 1144
                         .:|..:.:|:.|..:...|.:::.|.|..:|.|..: |......|.::.|..
Human  1277 ISPDIRVQVDGSIGRSPTDEIANLVPSVQYVDKTSLGSDSSTQAKDAHLSPKRPWKEPVKAEERG 1341

  Fly  1145 Q-DRSLRNDSAGQESVAECQSL 1165
            : .:::..|...:..:.|...|
Human  1342 RFGKAIEKDDCDETGIEEANEL 1363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	43/223 (19%)
		CYCc	256..453	CDD:214485	101/224 (45%)
		Guanylate_cyc	294..476	CDD:278633	96/187 (51%)
		CYCc	860..1071	CDD:214485	99/212 (47%)
		Guanylate_cyc	892..1092	CDD:278633	103/201 (51%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	35/201 (17%)
		CYCc	326..544	CDD:214485	100/221 (45%)
		Guanylate_cyc	385..573	CDD:278633	97/189 (51%)
		CYCc	1043..1243	CDD:214485	99/212 (47%)
		Guanylate_cyc	1069..1260	CDD:278633	101/198 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810