Protein Alignment Ac3 and ADCY8

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001106.1
• Gene: ADCY8 / 114
• HGNCID: 239
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 1190
• Identity: 395/1190 - (33%)
• Similarity: 611/1190 - (51%)
• Gaps: 152/1190 - (12%)

  Fly    31 NDSDVAGGVGITGGGVVILP-------QHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTI--- 85
            :|..:.||....|   ||.|       ...|..||..|.:.|||.       :..:.|:..:
Human   139 SDFFLNGGYSYRG---VIFPTLRNSFKSRDLERLYQRYFLGQRRK-------SEVVMNVLDVLTK 193

  Fly    86 -----------GIPWDQSAPTRVINCCMLLAY-----LALTALLHIGRRSDKPALRRFHQILLII 134
                       ..|.|   |.:.|    ||.:     :.:.||:.:.:.:......::..::..:
Human   194 LTLLVLHLSLASAPMD---PLKGI----LLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWV 251

  Fly   135 VPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL---IFLGLSIGCITYFIC 196
            ......|.:.|.:.:.         .|.:|:.:...|..|..|||.|   |..||....:...:.
Human   252 AMTTQILAAGLGYGLL---------GDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQ 307

  Fly   197 LSLPVGYSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSA 261
            :.:|    ....:..||:.|.|||.......|:...::.:..|::||||.::.:|.::.:|.::.
Human   308 VVIP----RLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQ 368

  Fly   262 EQERLLLSVLPKHVAIKMREDLGSSSSE----AFKKIYMSRHENVSILYADIVGFTAISSTYSAQ 322
            .||||:|||||:.|.::|..|:.:...|    .|.:||:.|:||||||:||:.|||.:|:|.|||
Human   369 RQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQ 433

  Fly   323 DLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQ 387
            :||:|||||||||||||.::..||||||||||||:||.|:.|.|||..||.|||||:|.|:||:.
Human   434 ELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRS 498

  Fly   388 KANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEF 452
            :....||||:|||:|:||.|:||.|:|||||:|.||::|||:||.|..||:|||..||..|||::
Human   499 RTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDY 563

  Fly   453 EVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTD-IVSDEDD 516
            .||...|::|.|.||...::||.|.:...:..|.....:.|:.:.....|...:.|: ..|.|..
Human   564 NVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELP 628

  Fly   517 NDATLDDEELLA---QNSVS---NGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKD 575
            .|..:..:..||   :||::   |.....:.|.:..||      ..:|::..:..|.|.:...:.
Human   629 FDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEE------INKRIEHTIDLRSGDKLRREH 687

  Fly   576 TNIF-LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCI-----DVLYSYLVLPRSTLHFINIAAP 634
            ...| |.||:..||..|:..|:......|:.|.:|...     .:|.|..|:|.:    |..:..
Human   688 IKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMT----IQFSIL 748

  Fly   635 LVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVR 699
            ::..:.||:|:.||.:. .||..........|: |::.....|..::.|.|...|....:..|.:
Human   749 IMLHSALVLITTAEDYK-CLPLILRKTCCWINE-TYLARNVIIFASILINFLGAILNILWCDFDK 811

  Fly   700 TEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLIL 764
            :                                :|...:.....||.|:...||.|....|||.:
Human   812 S--------------------------------IPLKNLTFNSSAVFTDICSYPEYFVFTGVLAM 844

  Fly   765 IAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEH--QPIISTRYAASGLLLVAA 827
            :..||..:|..:.|:.:||.:.|::......:...|:...|:..|  :..:.|:..:..|:.:..
Human   845 VTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFL 909

  Fly   828 LALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDL 892
            ||:....:.:::..|:.|.|:.:..|:.....::|:.||.::.|:||.|||.||::. .|.:::|
Human   910 LAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEK-DRDNEEL 973

  Fly   893 YSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGS 957
            |||||..|||:|||:|.|:||||:..:||||:||||.|||:|:|||.||...:||||.|||||||
Human   974 YSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGS 1038

  Fly   958 TYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITA 1022
            ||||.||::.::....|     :|.||..|.:|:|.|..::|.||:.|||:|.|::||:||.:.|
Human  1039 TYMAVSGLSPEKQQCED-----KWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVA 1098

  Fly  1023 GVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG----KG 1083
            |||||:||.|||||.|||:||||:|||.:|.|||.|||..||:..|:.|..||.:.|||    :|
Human  1099 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEG 1163

  Fly  1084 QLMTFYLQGK--------------SQSSAEPVASGVV-VLNGQDSSAV----ESTSELEASDIKM 1129
            ::.|::|.|:              .|.|...|..|:| .||.|....:    .:|..::....:.
Human  1164 KIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRR 1228

  Fly  1130 PLLKMNGPEQSLEID-QDRS 1148
            .||..:|.|...:.: .|:|
Human  1229 TLLSPSGTEPGAQAEGTDKS 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	144/339 (42%)
		Guanylate_cyc	294..476	CDD:425528	111/181 (61%)
		Guanylate_cyc	892..1092	CDD:425528	114/203 (56%)
ADCY8	NP_001106.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146	1..182		14/52 (27%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146	1..109
		Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..92
		AcyC	214..567	CDD:441717	150/369 (41%)
		Guanylate_cyc	405..589	CDD:425528	112/183 (61%)
		Adcy_cons_dom	617..712	CDD:461877	23/100 (23%)
		Guanylate_cyc	973..1172	CDD:425528	114/203 (56%)
		Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146	1109..1251		49/140 (35%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146	1200..1215		4/14 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1223..1251		6/26 (23%)