Protein Alignment Ac3 and ADCY7

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_011521137.1
• Gene: ADCY7 / 113
• HGNCID: 238
• Length: 1086
• Species: Homo sapiens
• Alignment Length: 1178
• Identity: 374/1178 - (31%)
• Similarity: 569/1178 - (48%)
• Gaps: 248/1178 - (21%)

  Fly    51 QHVLNE---------LYHNYSI-KQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTR---VINCCM 102
            ::.|||         ||..|.: .|....|...:..||...:..|.|.:.|..|:|   ::....
Human     6 RYFLNEGEEGPDQDALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAF 70

  Fly   103 LL--AYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGW 165
            |:  .:.||:.|:::     :..|||:.:.|.::....|..|.      ||::..::: :....|
Human    71 LVLAVFAALSVLMYV-----ECLLRRWLRALALLTWACLVALG------YVLVFDAWT-KAACAW 123

  Fly   166 A-----ILLNFLVYVTLPLQL---IFLGLSIGCITYFICL-SLPVGYSHWDSLLSNQLAANAVLI 221
            .     :.:.|:||..||..:   :.:| ::...::.:.| ||..|::.....:..||.||||:.
Human   124 EQVPFFLFIVFVVYTLLPFSMRGAVAVG-AVSTASHLLVLGSLMGGFTTPSVRVGLQLLANAVIF 187

  Fly   222 ATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMR------ 280
            ....|.|..:....:...:..|....|.::::..:..:..:||.|||||||.|:::.|:
Human   188 LCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIER 252

  Fly   281 ----EDLGSSSSEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEK 341
                .|........|..:|:.||:|||||||||||||.::|..|.::||.:|||||.:||::|:.
Human   253 LKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKA 317

  Fly   342 YQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLA 406
            .:.:|||||||||||:||.|...|.||..||.|||.|.:|||.|::.....::||||||:|.||.
Human   318 NECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLC 382

  Fly   407 GILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGL 471
            |::|.|:||:||:|.||.|||:||::|..|||||::.||..|:..:|||...|::|:..|:...:
Human   383 GVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNI 447

  Fly   472 KTYFI--------------------------------TKVVKAF--ASPCAKKINETQA----EI 498
            :||.:                                |:.::::  |.|.| .:|..::    |.
Human   448 RTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFA-HLNHRESVSSGET 511

  Fly   499 AHPN--------------PNGSTTDIVSDEDDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQ 549
            ..||              |:.|.:.....|||   :.|||.|.|...:|:
Human   512 HVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDD---SYDDEMLSAIEGLSS--------------- 558

  Fly   550 VKLENFKQRLKDELVTRDGHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPL--------LAA 606
                           ||.    ....::.|..|.:..||:   .:...|...|:        .|:
Human   559 ---------------TRP----CCSKSDDFYTFGSIFLEK---GFEREYRLAPIPRARHDFACAS 601

  Fly   607 LLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISL--AESFSGMLPK--FFVDVSKRFND 667
            |:..|| :|...|::||:..  :.::..||...:.:|:.|  |..||...|.  ....:|:|...
Human   602 LIFVCI-LLVHVLLMPRTAA--LGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVET 663

  Fly   668 ITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHL 732
            ...:|...|:   ||||..                        :|.::   |||.:......|
Human   664 QPLLRLTLAV---LTIGSL------------------------LTVAI---INLPLMPFQVPE-- 696

  Fly   733 LPASFVEQMRDAVPTERVL---YPSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNI 794
            ||......:..|....|.|   .|.|..:. ||..||.:|..:::...|::||  ..||..|..:
Human   697 LPVGNETGLLAASSKTRALCEPLPYYTCSC-VLGFIACSVFLRMSLEPKVVLL--TVALVAYLVL 758

  Fly   795 FIM-------------------------------QDLYALEDDFEHQPIISTRYAASGLLLVAAL 828
            |.:                               :||..:.:.:               |::..:
Human   759 FNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFY---------------LVLFYI 808

  Fly   829 ALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLY 893
            .|.||:|.:|:..|:...||.:..::.|....|...|..|:.||||.|||.||:.:  :.::|.|
Human   809 TLLTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGD--KLNEDWY 871

  Fly   894 SQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGST 958
            .|||..|.|:|||:|:|..||:|..||.:||||||.|||:|:|||.||..|:|..:.||||||||
Human   872 HQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGST 936

  Fly   959 YMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAG 1023
            ||||:|::|.....|. .:..:.:|:.::|||::.|...|..||..|||.|.|::||||||:.||
Human   937 YMAAAGLSVASGHENQ-ELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAG 1000

  Fly  1024 VIGARKPHYDIWGNTVNVASRMESTGKAGAI------QVTEETCNILRLFGYTFLQRGLVAVKGK 1082
            |||||||.||||||||||||||||||:.|.|      |||||||.||:..||:...|||:.||||
Human  1001 VIGARKPQYDIWGNTVNVASRMESTGELGKIQVSLPFQVTEETCTILQGLGYSCECRGLINVKGK 1065

  Fly  1083 GQLMTFYL 1090
            |:|.|:::
Human  1066 GELRTYFV 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	131/351 (37%)
		Guanylate_cyc	294..476	CDD:425528	96/181 (53%)
		Guanylate_cyc	892..1092	CDD:425528	117/205 (57%)
ADCY7	XP_011521137.1	AcyC	47..432	CDD:441717	141/397 (36%)
		Guanylate_cyc	270..453	CDD:425528	96/182 (53%)
		Adcy_cons_dom	485..593	CDD:461877	27/148 (18%)
		Guanylate_cyc	871..1073	CDD:425528	117/202 (58%)