Protein Alignment Ac3 and ADCY6

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001377760.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1137
• Identity: 376/1137 - (33%)
• Similarity: 569/1137 - (50%)
• Gaps: 198/1137 - (17%)

  Fly    54 LNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLLAYLALTALLHIGRR 118
            |..||..|..:..:|.|...:....|.....:..   .:||.|....  .:|.||..|.|.:|
Human   136 LERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAF---HAAPARPQPA--YVALLACAAALFVG-- 193

  Fly   119 SDKPALRRFHQILLIIVPR------ALWLLSILHFTVYVIL--------------QPSFSPRDLL 163
                        |:::..|      ::|::|      ||:|              .|. ||...|
Human   194 ------------LMVVCNRHSFRQDSMWVVS------YVVLGILAAVQVGGALAADPR-SPSAGL 239

  Fly   164 GWAILLNFLVYVTLPLQL---IFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAA 225
            ...:...::.|..||:::   :..||.:..:...:...|..|    |:.|..||.||.:|.....
Human   240 WCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRG----DAFLWKQLGANVLLFLCTN 300

  Fly   226 LIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSE- 289
            :||:..::..|..|::||.|.:..::.::.::.::.:||||||||||:|||::|:||:.:...:
Human   301 VIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDM 365

  Fly   290 AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCY 354
            .|.|||:.:|:|||||:|||.|||:::|..:||:||..|||||||||:||.:...||||||||||
Human   366 MFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCY 430

  Fly   355 YCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVY 419
            ||:||.|:.|.|||..||.||:.|::||..|::.....|:||||||:|.|..|:||.|:|||||:
Human   431 YCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVW 495

  Fly   420 SKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI------TK 478
            |.||.|||.||:.|:|||:||:..||.:|||::|||...|.:|...|:...::|:.|      .|
Human   496 SNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRK 560

  Fly   479 VVKAFASPCAKKINETQAEIAH-----------------------------PNPNGSTTDIVSDE 514
            ..||..:    |:..|:|....                             ...|..|.|.::.|
Human   561 EEKAMLA----KLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPE 621

  Fly   515 DDNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIF 579
            |:.|      |.|::           |:.|...:|::.::.::.|
Human   622 DEVD------EFLSR-----------AIDARSIDQLRKDHVRRFL-------------------- 649

  Fly   580 LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVI 644
            |.|:...||:.|:...:|.....:..||||.|.......|:.|.|||.....|:..:.:.:.|:|
Human   650 LTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLI 714

  Fly   645 SLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEF 709
            ....|...:.||....:|:     :.||..|.   :..:|       .|.|..|.|..|.:....
Human   715 CAVYSCGSLFPKALQRLSR-----SIVRSRAH---STAVG-------IFSVLLVFTSAIANMFTC 764

  Fly   710 NVT--ASLESDINLVVEGMVTAEHL--------LPASFVEQMRDAVPTERVLYPSYLSNFGVLIL 764
            |.|  .|..:.:..:....:||.||        |.|...|   ..:||  ..:|.|.....:|.|
Human   765 NHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCE---GTMPT--CSFPEYFIGNMLLSL 824

  Fly   765 IAIAVIAQLTHLTKILLLLSIAALHCYF-------NIFIMQDLY-------ALEDDFEHQPI--- 812
            :|.:|...::.:.|:.::..:..::...       .||...||.       :..:.|:....
Human   825 LASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAA 889

  Fly   813 --ISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPV 875
              ::.:|....:|||.||||...|:.::...|:.|.||.:...:||...:::..|..|::|:||.
Human   890 GRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPK 954

  Fly   876 HVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDAL 940
            .||.||:...:| :|:||.||...|.|:|||:.|||:||.|...||:|:||||.|||:|:|||.:
Human   955 DVAAHFLARERR-NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEI 1018

  Fly   941 LELPQFQDIIKIKTIGSTYMAASGIN------VQRTVRNDAPITERWSHLAILVEFALELKHALQ 999
            :...:|:.:.||||||||||||||:|      |.|            ||:..|.::|:.|...::
Human  1019 ISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR------------SHITALADYAMRLMEQMK 1071

  Fly  1000 SINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNIL 1064
            .|||.|||:|.:|:|:|.||:.|||||||||.||||||||||:|||:|||....||||.:...:|
Human  1072 HINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVL 1136

  Fly  1065 RLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQS 1096
            ...||....||:|.|||||::.|::|.|...|
Human  1137 AAKGYQLECRGVVKVKGKGEMTTYFLNGGPSS 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	48/180 (27%)
		CYCc	256..453	CDD:214485	112/197 (57%)
		Guanylate_cyc	294..476	CDD:278633	101/181 (56%)
		CYCc	860..1071	CDD:214485	107/216 (50%)
		Guanylate_cyc	892..1092	CDD:278633	106/205 (52%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454	64/261 (25%)
		Guanylate_cyc	370..554	CDD:306677	102/183 (56%)
		DUF1053	582..668	CDD:399378	17/122 (14%)
		Guanylate_cyc	970..1164	CDD:306677	106/205 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710