Protein Alignment Ac3 and ADCY5

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 1165
• Identity: 374/1165 - (32%)
• Similarity: 591/1165 - (50%)
• Gaps: 177/1165 - (15%)

  Fly    33 SDVAGGVGITGGGVVIL----------------PQHVLNELYHNYSIKQRRSGLKWFVFAAALFN 81
            |....|.|...|.|:.|                |...|..||..|..:..:|.|.  :..|.|..
Human   189 SSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLT--MLMAVLVL 251

  Fly    82 IWTIGIPWDQSAPTRVINCCMLLAYLALTA-----LLHIGRRSDKPALRRFHQIL----LIIVPR 137
            :..:.:.:..:.|.      :.|.|||:.|     :|.:....::.|..:.|..|    ||.|..
Human   252 VCLVMLAFHAARPP------LQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVL 310

  Fly   138 ALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVG 202
            |:.::.:|      :.||. |..:.:.|.:...:.:|..||:::....|| |.:...:.|::.:.
Human   311 AVQVVGLL------LPQPR-SASEGIWWTVFFIYTIYTLLPVRMRAAVLS-GVLLSALHLAIALR 367

  Fly   203 YSHWDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLL 267
            .:..|..|..||.:|.::.:...::|:..::..|..|::||.|.::.::.::..:.::.:|||||
Human   368 TNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLL 432

  Fly   268 LSVLPKHVAIKMREDLGSSSSE-AFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNEL 331
            |||||:|||::|:.|:.:...: .|.|||:.:|:|||||:|||.|||:::|..:||:||..||||
Human   433 LSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNEL 497

  Fly   332 FARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMR 396
            |||||:||.:...||||||||||||:||.|:.|.|||..||.||:.|::||..|::.....|:||
Human   498 FARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMR 562

  Fly   397 VGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEK 461
            ||||:|.|..|:||.|:|||||:|.||.|||.||:.|||||:||:..||.:|||::|||...|.:
Human   563 VGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGE 627

  Fly   462 REELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTT------------------ 508
            |...|:...::|:.|.:        |.:|..|.:|.||..|...:.:
Human   628 RNAYLKEHSIETFLILR--------CTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHL 684

  Fly   509 --DIVSDEDDNDATLDDEELLAQNSVSNGHQI----GIAVTADEEEQVKLENFKQRLKDELVTRD 567
              :.||.|.......|.::..||.|.:...::    |.|:.|...::::.|:.::.|
Human   685 GGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFL-------- 741

  Fly   568 GHENLTKDTNIFLRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRS--TLHFIN 630
                        |.|:.|.||:.|:...:......:..|.||..........::|.|  .|.|..
Human   742 ------------LTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYL 794

  Fly   631 IAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFF-- 693
            ..:.|  :.::|.:|:..|...:.|.....:|::.........|..:.....:..:..::||.
Human   795 TCSLL--LTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCN 857

  Fly   694 ---FVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSY 755
               .:..:..||.:|.|:.|.....||.:|..:..             ||.....|.....:|.|
Human   858 SRDLLGCLAQEHNISASQVNACHVAESAVNYSLGD-------------EQGFCGSPWPNCNFPEY 909

  Fly   756 LSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYF------NIFIMQDL-------------- 800
            .:...:|.|:|.:|..|::.:.|::|:|:|..::...      .:|...||
Human   910 FTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGT 974

  Fly   801 --YALEDDFEHQPIISTRYAASG--------------------LLLVAALALSTLARHMDHEDRV 843
              ::|.::..|:.:.:..|..||                    ::.|..|||...|:.::...|:
Human   975 SQWSLCENLRHRRMEAGTYFPSGVKEQSPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARL 1039

  Fly   844 IFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMP 908
            .|.||.:..|:||...:::..|..|::|:||..||.||:...:| :|:||.||...|.|:|||:.
Human  1040 DFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERR-NDELYYQSCECVAVMFASIA 1103

  Fly   909 NFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGIN------V 967
            |||:||.|...||:|:||||.|||:|:|||.::...:|:.:.||||||||||||||:|      |
Human  1104 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1168

  Fly   968 QRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHY 1032
            .:|            |:..|.:||::|...::.|||.|||:|.:|:|:|.||:.|||||||||.|
Human  1169 GKT------------HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1221

  Fly  1033 DIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQG 1092
            |||||||||||||:|||....||||.:...:|....|....||:|.|||||::||::|.|
Human  1222 DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	44/161 (27%)
		CYCc	256..453	CDD:214485	112/197 (57%)
		Guanylate_cyc	294..476	CDD:278633	102/181 (56%)
		CYCc	860..1071	CDD:214485	107/216 (50%)
		Guanylate_cyc	892..1092	CDD:278633	107/205 (52%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454	67/284 (24%)
		Guanylate_cyc	460..633	CDD:306677	100/172 (58%)
		DUF1053	668..760	CDD:399378	18/111 (16%)
		Guanylate_cyc	1087..1281	CDD:306677	107/205 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710