DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac3 and ADCY3

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:XP_011530791.1 Gene:ADCY3 / 109 HGNCID:234 Length:1186 Species:Homo sapiens


Alignment Length:1215 Identity:451/1215 - (37%)
Similarity:648/1215 - (53%) Gaps:202/1215 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SDVAGGVGIT-------GGGVVILPQHV--------LNELYHNYSIKQRRSGLKWFVFAAALFNI 82
            ||...|||.|       .|..:.||:.:        |..||..|..:||...|...|..||||:.
Human    26 SDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC 90

  Fly    83 WTIGIPWDQSAPTRVINCCML-----LAYLA-----------LTALLHIGRRSDKPALRRFHQIL 131
            :.            |:.|.::     ||.||           |..|...|...|:...|      
Human    91 YV------------VVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRR------ 137

  Fly   132 LIIVPRALWLLSILHFTVYVILQ--PSFSPRDLLGWAILLNFLVYVTLPLQL--IFLGLSIGCIT 192
              ::|..||||.......|:.|.  .:.:..|.:||.:...|..::||||.|  |.:...:.|:.
Human   138 --VLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVV 200

  Fly   193 YFICLSLPVGYSHWDSL----LSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVK 253
            :.:.|.:.|.....:.|    |..::.||..|...|..:|::.|:|.:.|.::|||||::|||||
Human   201 HTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVK 265

  Fly   254 MVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSS----EAFKKIYMSRHENVSILYADIVGFTA 314
            |.:||||.:||.|:||:||||||.:|.:|:....|    :.|..:||.||||||||:|||||||.
Human   266 MNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQ 330

  Fly   315 ISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMV 379
            :||..|||:|||:|||||||||:||.||.||||||||||||||.|.||.|.||||..:.|||:||
Human   331 LSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMV 395

  Fly   380 KAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAG-------- 436
            :||.||::|..:.||||||:|||.||.|:|||::||:||:|.||.:|||||:.|..|        
Human   396 EAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERL 460

  Fly   437 --------------RVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI---TKVVKAFA 484
                          |||||..|:..|.|||:||...|..|.:.|...|::||.|   ...||..|
Human   461 YSCVVAPTLRLRWERVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTA 525

  Fly   485 -------------SPCAKKINETQAEIAHPNPNGS--TTDIVSDE-DDNDATLDDEEL--LAQNS 531
                         :|.:.| :.:.|.|....||||  ::...|:: ::.||.|....|  |..:.
Human   526 TQNGLNGSALPNGAPASSK-SSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTLSHLPHSR 589

  Fly   532 VSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHE---------------NLTKDTNIFL- 580
            ...|.|.......:...:::|::...|:.|  .:.|.||               .:.|..|.|| 
Human   590 CLPGSQADNPSFPNPRRRLRLQDLADRVVD--ASEDEHELNQLLNEALLERESAQVVKKRNTFLL 652

  Fly   581 --RFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVV 643
              ||.:|::|..|:|.:|..|......:.:|.....|...|:.|....:::......:.:.:|.:
Human   653 SMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTI 717

  Fly   644 ISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESE 708
            .|||..|....||..|..|...:...:.|...|::....:..:||:||...:.:.       ...
Human   718 CSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYY-------TGP 775

  Fly   709 FNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQL 773
            .|.||.:|::                .|.:|.            |.|.:...||.|||..::.|:
Human   776 SNATAGMETE----------------GSCLEN------------PKYYNYVAVLSLIATIMLVQV 812

  Fly   774 THLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQ---------------------------- 810
            :|:.|:.|:|.:|......|::..:.::   |:::|:                            
Human   813 SHMVKLTLMLLVAGAVATINLYAWRPVF---DEYDHKRFREHDLPMVALEQMQGFNPGLNGTDSR 874

  Fly   811 -PIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLP 874
             |::.::|:.:.::.:..|:....:||::...|.:|.||.||.:|||...:||:.|||||.|:||
Human   875 LPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLP 939

  Fly   875 VHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDA 939
            .|||.||:.:.||. ::||||:|.|:||:|||:|||:|||:||::||.|:||||||||:|||||:
Human   940 EHVARHFLGSKKRD-EELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDS 1003

  Fly   940 LLELPQFQDIIKIKTIGSTYMAASGI-------NVQRTVRNDAPITERWSHLAILVEFALELKHA 997
            ||:.|:|:.|.||||||||||||||:       ....:.:.|....|||.|||.|.:|||.:|..
Human  1004 LLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDT 1068

  Fly   998 LQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCN 1062
            |.:||.||||:|:|::|:|.|.:.||||||||||||||||||||||||||||..|.|||.|||..
Human  1069 LTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQV 1133

  Fly  1063 ILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGVVV 1107
            |||.:|:.|::||.:.|||||:|:||:|:|:.:.:..|....|.:
Human  1134 ILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTL 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 58/165 (35%)
CYCc 256..453 CDD:214485 127/222 (57%)
Guanylate_cyc 294..476 CDD:278633 117/203 (58%)
CYCc 860..1071 CDD:214485 134/217 (62%)
Guanylate_cyc 892..1092 CDD:278633 129/206 (63%)
ADCY3XP_011530791.1 AC_N <44..303 CDD:292831 85/278 (31%)
CYCc 273..490 CDD:214485 122/216 (56%)
Guanylate_cyc 310..516 CDD:278633 118/205 (58%)
CYCc 925..1143 CDD:214485 134/218 (61%)
Guanylate_cyc 956..1163 CDD:278633 129/206 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144496
Domainoid 1 1.000 262 1.000 Domainoid score I1961
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H2978
Inparanoid 1 1.050 707 1.000 Inparanoid score I658
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG50088
OrthoDB 1 1.010 - - D154265at2759
OrthoFinder 1 1.000 - - FOG0007386
OrthoInspector 1 1.000 - - oto89392
orthoMCL 1 0.900 - - OOG6_100296
Panther 1 1.100 - - LDO PTHR45627
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5315
SonicParanoid 1 1.000 - - X5510
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.800

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