DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac3 and ADCY2

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:1201 Identity:389/1201 - (32%)
Similarity:600/1201 - (49%) Gaps:232/1201 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 QTTSRRRQ----NDSDVAGGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIW 83
            |...|||:    ...:.|||    |.|   ||:. .:.||.:|....::..|..|:....:.   
Human     3 QEAMRRRRYLRDRSEEAAGG----GDG---LPRS-RDWLYESYYCMSQQHPLIVFLLLIVMG--- 56

  Fly    84 TIGIPWDQSAPTRVINCCMLLAY---LALTALLHIGRRSDKP-ALRRFHQILLIIVPRALW--LL 142
                           :|..|||.   |.|....|:......| ||..|..|.:::...:::  ||
Human    57 ---------------SCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLL 106

  Fly   143 SILHFTVYVILQP----------SFSPRDLLGWAILLNFLVYVTLPLQL------IFLGLSIGCI 191
            .:....:::.|..          :.||.|.:.:.:.:.|:||..||..:      ..|..|...|
Human   107 RLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTI 171

  Fly   192 TYFICLS-LPVGYSH--WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVK 253
            ...:||| .|.|..|  |      |:.||.::.....|.|..:..:.|...::.:.:....::.:
Human   172 VLSVCLSATPGGKEHLVW------QILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSR 230

  Fly   254 MVIEEQSAEQERLLLSVLPKHVAIKMREDL-----GSSSSEA-----FKKIYMSRHENVSILYAD 308
            :.:|.:..:|||||||:||.|:|::|:.::     |..:.:.     |..:|:.||.||||||||
Human   231 IKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYAD 295

  Fly   309 IVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVH 373
            |||||.::|..|..:||.||||||.:||::|::.:.:|||||||||||:||.|...|:||..||.
Human   296 IVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK 360

  Fly   374 MGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRV 438
            |||.|.:|||.|:......::||||:|:|.||.|::|.::||:||:|.||.|||.||:.|..|||
Human   361 MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRV 425

  Fly   439 HISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFI--------------------------- 476
            |||..||..|||.::||...|:.|:..|:...:||||:                           
Human   426 HISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRA 490

  Fly   477 ----TKVVKAFASPCAKKINETQAEIAHPNPNG--STTDIVSDEDDNDATLDDEELLAQNSVSNG 535
                |:.::::.:  ||.........:....||  ||||:.               :.|::..| 
Human   491 SVRMTRYLESWGA--AKPFAHLHHRDSMTTENGKISTTDVP---------------MGQHNFQN- 537

  Fly   536 HQIGIAVTADEEEQVKLENFKQRLKDELVTR-----DG---------HENLTKDTNIFLRFKNPQ 586
                        ..::.::.|:|.::||..|     ||         .|::.:   |.|.|.|..
Human   538 ------------RTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQR---ISLLFYNKV 587

  Fly   587 LEQLYAVYREPYSSLPLL------AALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVIS 645
            ||:.|..     ::||..      |.|:..||.:: ..||||::::..|:..|..:.:|.::.: 
Human   588 LEKEYRA-----TALPAFKYYVTCACLIFFCIFIV-QILVLPKTSVLGISFGAAFLLLAFILFV- 645

  Fly   646 LAESFSGMLPKFFVDVSKRFND-ITFVRELAAII-------IALTIGFSNVI------DMFFFVT 696
               .|:|.|    :..||:.:. :.::.:.:.||       |:|||..:.:|      :|||...
Human   646 ---CFAGQL----LQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSD 703

  Fly   697 FVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHL--LPASFVEQMRDAVPTERVLYPSYLSNF 759
               :|..:..:......|..:..|.|  .::.|::|  ||                    |....
Human   704 ---SEETIPPTANTTNTSFSASNNQV--AILRAQNLFFLP--------------------YFIYS 743

  Fly   760 GVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDD----FEHQPI---ISTRY 817
            .:|.||:.:|..::.:..|:|:::  .||..|..|.:....:.|.|.    ||...|   :.|..
Human   744 CILGLISCSVFLRVNYELKMLIMM--VALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMG 806

  Fly   818 AASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFM 882
            :.|  |.:..:.|..|.|..::..|:.|.||.:..:::|....|...|..|:.||||.||||||:
Human   807 SVS--LSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFL 869

  Fly   883 KNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQ 947
            ..:.: :::||.|||..|.|:|||:|:|.:||:|..||.:||||||.|||:|:|||.||..|:|.
Human   870 ARSLK-NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFS 933

  Fly   948 DIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLK 1012
            .:.||||||||||||:|::...:..:......::.|:..:||||..|...|.:||:.|||.|.|:
Human   934 GVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLR 998

  Fly  1013 MGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLV 1077
            :||||||:.||||||:||.||||||||||||||:|||....|||||||..:|:..|||...||::
Human   999 VGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGII 1063

  Fly  1078 AVKGKGQLMTFYL-----QGKSQSSAEPVAS 1103
            .|||||.|.|:::     :..|||:   |||
Human  1064 NVKGKGDLKTYFVNTEMSRSLSQSN---VAS 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 42/183 (23%)
CYCc 256..453 CDD:214485 105/206 (51%)
Guanylate_cyc 294..476 CDD:278633 98/181 (54%)
CYCc 860..1071 CDD:214485 115/210 (55%)
Guanylate_cyc 892..1092 CDD:278633 112/204 (55%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831 57/250 (23%)
CYCc 236..439 CDD:214485 104/202 (51%)
Guanylate_cyc 281..465 CDD:278633 99/183 (54%)
DUF1053 495..599 CDD:283888 27/141 (19%)
CYCc 848..1056 CDD:214485 114/208 (55%)
Guanylate_cyc 878..1077 CDD:278633 112/198 (57%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 12/16 (75%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

Return to query results.
Submit another query.