DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and ADCY1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	1184	Identity:	393/1184 - (33%)
Similarity:	588/1184 - (49%)	Gaps:	246/1184 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GGVGITGGGVVILPQHVLNELYHNYSIKQRRSGLKWF--VFAA----ALFNIWTIGIPWDQSAPT 95
            ||.|..||.             ...:...||.||:..  .||.    |||..:|:.:  :|:|..
Human    13 GGAGEPGGA-------------ERAAGTSRRRGLRACDEEFACPELEALFRGYTLRL--EQAATL 62

  Fly    96 RVINCCMLLA-YLALTALLHIGRRSDKPALRR---------FHQILLIIVPRALWL--------L 142
            :.:....||| .|||..||  |.....|.|.:         |..:|::...|:|.:        |
Human    63 KALAVLSLLAGALALAELL--GAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQL 125

  Fly   143 SILHFTVYVILQPSFS----PRDLLG------------WAILL-NFLVYVTLPLQLIFLGLSIGC 190
            ::|....:.:|...|:    .|...|            |.:|| .|:.|..||::.:   |:||
Human   126 ALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSL---LAIG- 186

  Fly   191 ITYFICLSLPVGYSH---------------WDSLLSNQLAANAVLIATAALIGLLYYFMGEAKQK 240
                  ..|.|..||               |     ..|.|||:|.....:.|:....:.|..|:
Human   187 ------FGLVVAASHLLVTATLVPAKRPRLW-----RTLGANALLFVGVNMYGVFVRILTERSQR 240

  Fly   241 RAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRHENVSIL 305
            :|||:|:..:|.::.:|:::.:|||||:|:||::||::|:||........|.|||:.||:|||||
Human   241 KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSIL 305

  Fly   306 YADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVL 370
            :|||||||.::|..:||:|||:|||||.:||.||.:....|||||||||||:||....:.|||..
Human   306 FADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHC 370

  Fly   371 CVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKA 435
            ||.|||.|:..|..|.:.....::||||:|||.||.|:||.|:||:||:|.||.|||.||::|..
Human   371 CVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435

  Fly   436 GRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFIT----------------KVVK--A 482
            |:|||:..|||.|||::|||..:|.:|...|:...::|:||.                |..|  .
Human   436 GKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMK 500

  Fly   483 FASPC--------AKKINETQAEIAHPNPNGSTTDIVSDEDDND---ATLDDEELLAQNSVSNGH 536
            |.:.|        .:|:  .:|||...|       :::.|||:.   .....|:|..::|.|.
Human   501 FKTVCYLLVQLMHCRKM--FKAEIPFSN-------VMTCEDDDKRRALRTASEKLRNRSSFST-- 554

  Fly   537 QIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIF-LRFKNPQLEQLYAVYREPYSS 600
              .:..|.   ...::..:..||.:...|    |....|.|.| |::|:.:.||.|...::.|.:
Human   555 --NVVYTT---PGTRVNRYISRLLEARQT----ELEMADLNFFTLKYKHVEREQKYHQLQDEYFT 610

  Fly   601 LPLLAALLVQCIDVLYSYLVLPRST---LHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVS 662
            ..::..|::..:..|...|:.|:|.   |..:.....||...:.:.|:..:.|.|
Human   611 SAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPG---------- 665

  Fly   663 KRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMV 727
                             .|||....|:.:|..|.                      |..|.:|.|
Human   666 -----------------CLTIQIRTVLCIFIVVL----------------------IYSVAQGCV 691

  Fly   728 TAEHLLPASFVEQ------------MRDAVPTERVLYPSYLSNFGVLILIA----IAVIAQLTHL 776
            ..  .||.::..:            .|.|:||    .|...::..:|..:.    :|:..:::.|
Human   692 VG--CLPWAWSSKPNSSLVVLSSGGQRTALPT----LPCESTHHALLCCLVGTLPLAIFFRVSSL 750

  Fly   777 TKILLLLSIAALHCYFNIFIMQDLYALE------------DDFEHQPIISTRYAASGLLLVAALA 829
            .|::||..:...:          :..||            ....::||::.      ||...|||
Human   751 PKMILLSGLTTSY----------ILVLELSGYTRTGGGAVSGRSYEPIVAI------LLFSCALA 799

  Fly   830 LSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYS 894
            |.  ||.:|...|:.:.|..:..|::|....::..|..:::|:||.|||:||:.:..|:. |||.
Human   800 LH--ARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNM-DLYY 861

  Fly   895 QSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTY 959
            |||::|||:|||:|||:|||.|...||.|:||||.|||:|:|||.|:|...::||.|||||||||
Human   862 QSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTY 926

  Fly   960 MAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGV 1024
            |||.|:......:....|:   |||:.|.:||:|:...|..||.||:|.|||::|||.||:.|||
Human   927 MAAVGLAPTSGTKAKKSIS---SHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGV 988

  Fly  1025 IGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFY 1089
            ||||:|.||||||||||||||:|||..|.||||||...:||...|.|:.||.|:|||||:::|::
Human   989 IGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYF 1053

  Fly  1090 LQGKSQSSAEPVAS 1103
            |:|::..:...:.|
Human  1054 LEGRTDGNGSQIRS 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	52/197 (26%)
		CYCc	256..453	CDD:214485	107/196 (55%)
		Guanylate_cyc	294..476	CDD:278633	98/181 (54%)
		CYCc	860..1071	CDD:214485	117/210 (56%)
		Guanylate_cyc	892..1092	CDD:278633	117/199 (59%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/27 (19%)
		AC_N	<161..292	CDD:292831	42/145 (29%)
		CYCc	258..453	CDD:214485	106/194 (55%)
		Guanylate_cyc	294..476	CDD:278633	98/181 (54%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		5/28 (18%)
		CYCc	826..1037	CDD:214485	118/214 (55%)
		Guanylate_cyc	859..1056	CDD:278633	117/199 (59%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		10/22 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710