DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and Adcy3

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	1172	Identity:	448/1172 - (38%)
Similarity:	651/1172 - (55%)	Gaps:	157/1172 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SDVAGGVGIT-------GGGVVILPQHV--------LNELYHNYSIKQRRSGLKWFVFAAALFNI 82
            ||...|||.|       .|..:.||:.:        |..||..|..:||...|...|..||||:.
Mouse    26 SDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDC 90

  Fly    83 WTIGI-----PWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLL 142
            :.:.:     ..|:.||..|....::|. :.|..|...|...|:.:.:        :||..||||
Mouse    91 YVVVMCAVVFSSDKLAPLMVAGFGLVLD-IILFVLCKKGLLPDRVSRK--------VVPYLLWLL 146

  Fly   143 SILHFTVYVILQPSFS----PRDLLGWAILLNFLVYVTLPLQL--IFLGLSIGCITYFICLSLPV 201
              :...::..|..:||    ..|.:||.....|..::||||.|  |.:...:.|:.:.:.|.:.|
Mouse   147 --ISAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTV 209

  Fly   202 GYSHWDSL----LSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAE 262
            .....|.|    |..::.||..|...|.::|::.|:|.:.|.::|||||::||||||.:||||.:
Mouse   210 AQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQ 274

  Fly   263 QERLLLSVLPKHVAIKMREDLGSSSS----EAFKKIYMSRHENVSILYADIVGFTAISSTYSAQD 323
            ||.|:||:||||||.:|.:|:....|    :.|..:||.||||||||:|||||||.:||..|||:
Mouse   275 QENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQE 339

  Fly   324 LVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQK 388
            |||:|||||||||:||.||.||||||||||||||.|.||.|.||||..:.|||:||:||.||::|
Mouse   340 LVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREK 404

  Fly   389 ANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFE 453
            ..:.||||||:|||.||.|:|||::||:||:|.||.:|||||:.|..||||||..|:..|.|||:
Mouse   405 TKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFD 469

  Fly   454 VEAAFGEKREELLRIAGLKTYFI----TKVVK----------------AFASPCAKKINETQAEI 498
            ||...|..|.:.|...|::||.|    .:|.|                |.:.|.:..:.||:...
Mouse   470 VEPGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSAVPNGAPASSKPSSPALIETKEPN 534

  Fly   499 AHPNPNGSTTDIVSDED---DNDATLDDEELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLK 560
            ...:.:|||::...:::   ||.:..:....|....:::.     .|.|.|:|    ....|.|.
Mouse   535 GSAHASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADR-----VVDASEDE----HELNQLLN 590

  Fly   561 DELVTRDGHENLTKDTNIFL---RFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLP 622
            :.|:.|:..: :.|..|.||   ||.:|::|..|:|.:|..|......:.:|.....:...|:.|
Mouse   591 EALLERESAQ-VVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDP 654

  Fly   623 RSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSN 687
            ....:::......|.:.:|.:.|:|..|....||..|..|...:...:.|...|::....:..:|
Mouse   655 WLMTNYVTFVVGEVLLLILTICSMAAIFPRSFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMAN 719

  Fly   688 VIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLY 752
            |:||...:.:..       ..:|:||.:|.|                ...:|.
Mouse   720 VVDMLSCLQYYM-------GPYNMTAGMELD----------------GGCMEN------------ 749

  Fly   753 PSYLSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQ------- 810
            |.|.:...||.|||..::.|::|:.|:.|:|.:.......|::....::   |:::|:
Mouse   750 PKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTALNLYAWCPVF---DEYDHKRFQEKDS 811

  Fly   811 -----------------------PIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVA 852
                                   |::.::|:.:.::.|..|:....:||::...|.:|.||.||.
Mouse   812 PMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVH 876

  Fly   853 EQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEE 917
            :|||...:||:.|||||.|:||.|||.||:.:.||. ::||||||.|:||:|||:|||:|||:||
Mouse   877 DQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRD-EELYSQSYDEIGVMFASLPNFADFYTEE 940

  Fly   918 TVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGI-------NVQRTVRNDA 975
            ::||.|:||||||||:|||||:||:.|:|:.|.||||||||||||||:       ....:.:.:.
Mouse   941 SINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEK 1005

  Fly   976 PITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVN 1040
            ...|||.|||.|.:|||.:|..|.:||.||||:|:|::|:|.|.:.|||||||||||||||||||
Mouse  1006 SDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVN 1070

  Fly  1041 VASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVASGV 1105
            |||||||||..|.|||.|||..|||.:|:.|::||.:.|||||:|:||:|:|:.:.:|.|..|.|
Mouse  1071 VASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSV 1135

  Fly  1106 VV 1107
            .:
Mouse  1136 TL 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	61/167 (37%)
		CYCc	256..453	CDD:214485	127/200 (64%)
		Guanylate_cyc	294..476	CDD:278633	117/181 (65%)
		CYCc	860..1071	CDD:214485	134/217 (62%)
		Guanylate_cyc	892..1092	CDD:278633	129/206 (63%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	86/269 (32%)
		Guanylate_cyc	310..494	CDD:306677	118/183 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		9/59 (15%)
		Guanylate_cyc	915..1122	CDD:306677	129/206 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834624
Domainoid	1	1.000	262	1.000	Domainoid score	I1944
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2978
Inparanoid	1	1.050	712	1.000	Inparanoid score	I636
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50088
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007386
OrthoInspector	1	1.000	-	-		oto92964
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5315
SonicParanoid	1	1.000	-	-		X5510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790