DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ac3 and Adcy4

DIOPT Version :9

Sequence 1:NP_610116.2 Gene:Ac3 / 35419 FlyBaseID:FBgn0023416 Length:1167 Species:Drosophila melanogaster
Sequence 2:NP_001348533.1 Gene:Adcy4 / 104110 MGIID:99674 Length:1077 Species:Mus musculus


Alignment Length:1096 Identity:368/1096 - (33%)
Similarity:555/1096 - (50%) Gaps:142/1096 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 WTIG--IPWDQSAPTRVINCCMLLAYLALTALLHIGRRSDKPALRRFHQILLIIVPRALWLLSI- 144
            |..|  :..|.|..|.|:  |.|..:..|     :|..|.:..|:|:.:.|..::..||..|.. 
Mouse    49 WASGRELTSDPSFLTTVL--CALGGFSLL-----LGLASREQQLQRWTRPLSGLIWVALLALGYG 106

  Fly   145 LHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLS--IGCITYFICLSLPVGYS-HW 206
            ..||..|:     |..|.:.:.:.:.|.||..|||.:.....:  |..:::.:.|.|.:|:. ..
Mouse   107 FLFTGGVV-----SAWDQVSFFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWQPES 166

  Fly   207 DSLLSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVL 271
            ...|..||||||||.....::|..:..:.|...:..|.||..||..:..::.:...||.||||:|
Mouse   167 QRALLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSIL 231

  Fly   272 PKHVAIKMREDL------GSSS----SEAFKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVK 326
            |.::|.:|:.::      |..|    :..|..:|:.||:.||:|||||||||.::|..|.::||.
Mouse   232 PAYLAREMKAEIMARLQAGQRSRPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVL 296

  Fly   327 MLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANS 391
            ||||||.:||::|::::.:|||||||||||:||.|...||||:.||.|||.|.:||:.::.....
Mouse   297 MLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGV 361

  Fly   392 PVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEA 456
            .::||||:|:|:||.|::|.::||:||:|.||.|||.||:.|..|||||:..|||.|.|.:.||.
Mouse   362 DINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVER 426

  Fly   457 AFGEKREELLRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATL 521
            |..|.|:..||..|..||.:       ..|.|::.:|          .|:...::|..:.:  |:
Mouse   427 ADTEHRDPYLRELGEPTYLV-------IDPRAEEEDE----------KGTAKGLLSSLEGH--TM 472

  Fly   522 DDEELLAQNSVSNG------------HQIGIAVTADEE---EQVKLENFK--QRLKDELVTRDGH 569
            ....|:.:...|.|            ..:..:....|:   .|..|:..:  :.|.|||.|.|..
Mouse   473 RPSLLMTRYLESWGAAKPFAHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGDAK 537

  Fly   570 -----ENL--------TKDTNIF-LRFKNPQLEQLYAVYREPYSSLPLLAALLVQCIDVLYSYLV 620
                 |.|        :||.|:. |.|:..::|:.|.:...|..........||...:.....||
Mouse   538 FFQVIEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLV 602

  Fly   621 LPRSTLHFINIAAPLVPIAMLVVISLAESFS----------GMLPKFFVDVSKRFNDITFVRELA 675
            ..|.....|..:...:...:|:.:..:|..:          ..||...|.|:.| .........|
Mouse   603 TTRPPALIITYSITFLLFFLLLFVCFSEHLTKCVQKGPKMLHWLPALSVLVATR-PGFRVALGTA 666

  Fly   676 AIIIALTIGFSNVI------DMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLP 734
            .|::..|:..::::      |..|..:      .||...||.:..:...:.|:            
Mouse   667 TILLVFTMAIASLLFLPVSSDCLFLAS------NVSSVTFNASWEMPGSLPLI------------ 713

  Fly   735 ASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILLLL--SIAAL------HCY 791
                     ::|...:.|..:..   ||..::.::...::...|:||||  .:|:.      |.:
Mouse   714 ---------SIPLISIPYSMHCC---VLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAW 766

  Fly   792 FNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKE 856
            .:..::..||....|.....:...:...:....:....|..|||..::..|:.|.||.::.:::|
Mouse   767 LSDCLIARLYQSPSDSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQERE 831

  Fly   857 TANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNN 921
            ....|......|:.||||.|||..|:...:| ::|||.|||..|.|||||:|:|.:||||..:|:
Mouse   832 ETETMENLTRLLLENVLPAHVAPQFIGQNRR-NEDLYHQSYECVCVLFASVPDFKEFYSESNINH 895

  Fly   922 QGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINV---QRTVRNDAPITER-WS 982
            :||||||.|||:|:|||.||..|:|..:.||||||||||||:|:|.   |.|.::    :|| .|
Mouse   896 EGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDTQQD----SERSCS 956

  Fly   983 HLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMES 1047
            ||..:||||:.|...|..||:.|||:|.|::|:||||:.||||||:||.||||||||||||||||
Mouse   957 HLGTMVEFAVALGSKLGVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMES 1021

  Fly  1048 TGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFYLQGKSQSSAEPVAS 1103
            ||..|.|||||||...|:..|||...||.:.|||||:|.|::|......:..|.||
Mouse  1022 TGVLGKIQVTEETARALQSLGYTCYSRGSIKVKGKGELCTYFLNTDLTRTGSPSAS 1077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ac3NP_610116.2 AC_N <127..285 CDD:292831 45/167 (27%)
CYCc 256..453 CDD:214485 99/206 (48%)
Guanylate_cyc 294..476 CDD:278633 96/181 (53%)
CYCc 860..1071 CDD:214485 123/214 (57%)
Guanylate_cyc 892..1092 CDD:278633 122/203 (60%)
Adcy4NP_001348533.1 AC_N <115..246 CDD:318454 38/130 (29%)
Guanylate_cyc 264..418 CDD:306677 84/153 (55%)
DUF1053 479..580 CDD:368844 20/100 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..524 3/21 (14%)
Guanylate_cyc 866..1065 CDD:306677 121/202 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100296
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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