Protein Alignment Ac3 and adcy4

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_002934331.3
• Gene: adcy4 / 100497212
• XenbaseID: XB-GENE-984909
• Length: 1072
• Species: Xenopus tropicalis
• Alignment Length: 1055
• Identity: 349/1055 - (33%)
• Similarity: 534/1055 - (50%)
• Gaps: 148/1055 - (14%)

  Fly   121 KPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL---I 182
            |..:::..||:.:::...|..|..    |::......|..|.:.|.:.:...:|..|||.:   |
 Frog    88 KKVVQKCMQIIGVVILGCLVTLGY----VFIFTSGLVSAWDQIYWTLFVIISLYTMLPLGMKWAI 148

  Fly   183 FLGLSIGC-ITYFICLSLPVGYSHWDSLLSN-----QLAANAVLIATAALIGLLYYFMGEAKQKR 241
            |.|||  | :.:.|.||:   |.....||..     |:.|:||::....:||..:..:.|:..|.
 Frog   149 FAGLS--CFVAHIIVLSV---YVSTVRLLPRDDVALQMIADAVILLCGNVIGGYHKCVTESALKD 208

  Fly   242 AFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL---------GSSSSEAFKKIYMS 297
            .:.||...:..::.:..|..:|||||||:||.::|.:|:.::         ...::..|..:|:.
 Frog   209 TYHEAINFIHSRLKLVSQERQQERLLLSILPAYIATEMKAEIIERLKEKRPQPENTNNFHNLYIK 273

  Fly   298 RHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPD 362
            ||::||||||||||||.:||..|.::||.||||||.:||::|:..:.:|||||||||||:||.|:
 Frog   274 RHKDVSILYADIVGFTLLSSECSPKELVLMLNELFGKFDQIAKDNECMRIKILGDCYYCVSGLPE 338

  Fly   363 ERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELAN 427
            ..|:||..||.|||.|.:||:.:::.....::||||:|:|.||.|::|.::||:||:|.||.|||
 Frog   339 FLPNHAKNCVLMGLDMCQAIRKLRKATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLAN 403

  Fly   428 KMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKIN 492
            .||:.|..|||||::.||:.|..|:|||.|...:|:..|:...:|||.:..          .:.|
 Frog   404 HMEAGGVPGRVHITEATLSHLENEYEVEDATLAQRDLYLKENNIKTYLVID----------PRAN 458

  Fly   493 ETQAEIAHPNPNGSTTDIVSD-----------EDDNDATLDDEELLAQNSVSNGHQIGIAV---- 542
            :.:||...|:.:.....:.:.           .:...|.|...:.|.....|..|.:.:.:
 Frog   459 DGEAEDILPSKSAEVPKMRASVRMTRYLESWGAEKPFAHLSHRDSLVPEPHSISHSMDLPMSPLS 523

  Fly   543 -TADEEEQVKLENFKQRLKD------ELVTRDGHENLTKDTN-IFLRFKNPQLEQLYAVYREPYS 599
             |..:|:........:.|.|      |::........:||.| |.|.|.:...|:.|.:     |
 Frog   524 QTWSQEKSRSTRETNESLNDNNFHIMEVLASQRQWKRSKDFNRITLYFNDKAAEKEYRL-----S 583

  Fly   600 SLPLLAALLVQCI-----DVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSG------- 652
            .||........|.     :.:...||..::....|:.....    ...::.|...|:|
 Frog   584 DLPSFKYYTACCFFIFACNFIVQILVSHKNAAFGISYGISF----FFFLLLLFTCFAGHLARCIL 644

  Fly   653 -------MLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFN 710
                   .||...:.:|.|    .::|....:...||:....|.::||.     .::...:..:|
 Frog   645 KGPQLLHWLPSLSIALSSR----PWLRVPLGVFTILTVLVMAVFNLFFL-----PDNNCPQQSWN 700

  Fly   711 VTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLY--PSYLSNFGVLILIAIAVIAQL 773
              :||..|                           |..::||  |.|: ...:|.|:|.:....:
 Frog   701 --SSLSPD---------------------------PEPQMLYSLPYYM-YCCILGLLACSAFLLM 735

  Fly   774 THLTKILLLLSIAALHCYFNIFIMQDLYALEDDF-------EHQPII--STRYAASGLLLVAALA 829
            ....| |:|||||.:  .:|:..::....|.|.:       ..:|.|  ..:...|..|.:....
 Frog   736 NFEAK-LILLSIALV--IYNVIFLETHSWLSDCYVNWLYMNHSRPGILKEPKVMGSISLFIFFFT 797

  Fly   830 LSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYS 894
            |..|:|..::..|:.|.||.:...::|....|...|..|:.||||..||:.|:...:| ::|||.
 Frog   798 LLALSRQNEYYCRLDFLWKRKFKMERERIETMENLNRVLLENVLPADVAQQFIGQNRR-NEDLYY 861

  Fly   895 QSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTY 959
            |||..|.|||||:|:|.:||:|...|::||||||.|||:|:|||.||..|:|..:.|||||||.|
 Frog   862 QSYDCVCVLFASIPDFKEFYTECDENHEGLECLRLLNEIIADFDELLSKPKFSSVEKIKTIGSAY 926

  Fly   960 MAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGV 1024
            |||:|:|......|.......::|:.|:||||:.|...|..||:.|||:|.|::||||||:.|||
 Frog   927 MAATGLNATSGQENPQDGDRNYNHIGIMVEFAIALIGKLDLINKHSFNNFKLRVGINHGPVVAGV 991

  Fly  1025 IGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFY 1089
            |||:||.||||||||||||||:|||..|.|||||||..:|...||...:||::.|||||||.|::
 Frog   992 IGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETTKVLEKLGYKCERRGVIKVKGKGQLCTYF 1056

  Fly  1090 LQGKSQSSAEPVASG 1104
            :      |.:...||
 Frog  1057 V------STDMARSG 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	134/350 (38%)
		Guanylate_cyc	294..476	CDD:425528	95/181 (52%)
		Guanylate_cyc	892..1092	CDD:425528	115/199 (58%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	47/170 (28%)
		Guanylate_cyc	270..453	CDD:425528	95/182 (52%)
		Adcy_cons_dom	483..588	CDD:461877	21/109 (19%)
		Guanylate_cyc	859..1057	CDD:425528	115/197 (58%)