DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and adcy4

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_002934331.3	Gene:	adcy4 / 100497212	XenbaseID:	XB-GENE-984909	Length:	1072	Species:	Xenopus tropicalis

Alignment Length:	1055	Identity:	349/1055 - (33%)
Similarity:	534/1055 - (50%)	Gaps:	148/1055 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KPALRRFHQILLIIVPRALWLLSILHFTVYVILQPSFSPRDLLGWAILLNFLVYVTLPLQL---I 182
            |..:::..||:.:::...|..|..    |::......|..|.:.|.:.:...:|..|||.:   |
Frog    88 KKVVQKCMQIIGVVILGCLVTLGY----VFIFTSGLVSAWDQIYWTLFVIISLYTMLPLGMKWAI 148

  Fly   183 FLGLSIGC-ITYFICLSLPVGYSHWDSLLSN-----QLAANAVLIATAALIGLLYYFMGEAKQKR 241
            |.|||  | :.:.|.||:   |.....||..     |:.|:||::....:||..:..:.|:..|.
Frog   149 FAGLS--CFVAHIIVLSV---YVSTVRLLPRDDVALQMIADAVILLCGNVIGGYHKCVTESALKD 208

  Fly   242 AFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDL---------GSSSSEAFKKIYMS 297
            .:.||...:..::.:..|..:|||||||:||.::|.:|:.::         ...::..|..:|:.
Frog   209 TYHEAINFIHSRLKLVSQERQQERLLLSILPAYIATEMKAEIIERLKEKRPQPENTNNFHNLYIK 273

  Fly   298 RHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPD 362
            ||::||||||||||||.:||..|.::||.||||||.:||::|:..:.:|||||||||||:||.|:
Frog   274 RHKDVSILYADIVGFTLLSSECSPKELVLMLNELFGKFDQIAKDNECMRIKILGDCYYCVSGLPE 338

  Fly   363 ERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELAN 427
            ..|:||..||.|||.|.:||:.:::.....::||||:|:|.||.|::|.::||:||:|.||.|||
Frog   339 FLPNHAKNCVLMGLDMCQAIRKLRKATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLAN 403

  Fly   428 KMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFASPCAKKIN 492
            .||:.|..|||||::.||:.|..|:|||.|...:|:..|:...:|||.:..          .:.|
Frog   404 HMEAGGVPGRVHITEATLSHLENEYEVEDATLAQRDLYLKENNIKTYLVID----------PRAN 458

  Fly   493 ETQAEIAHPNPNGSTTDIVSD-----------EDDNDATLDDEELLAQNSVSNGHQIGIAV---- 542
            :.:||...|:.:.....:.:.           .:...|.|...:.|.....|..|.:.:.:
Frog   459 DGEAEDILPSKSAEVPKMRASVRMTRYLESWGAEKPFAHLSHRDSLVPEPHSISHSMDLPMSPLS 523

  Fly   543 -TADEEEQVKLENFKQRLKD------ELVTRDGHENLTKDTN-IFLRFKNPQLEQLYAVYREPYS 599
             |..:|:........:.|.|      |::........:||.| |.|.|.:...|:.|.:     |
Frog   524 QTWSQEKSRSTRETNESLNDNNFHIMEVLASQRQWKRSKDFNRITLYFNDKAAEKEYRL-----S 583

  Fly   600 SLPLLAALLVQCI-----DVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSG------- 652
            .||........|.     :.:...||..::....|:.....    ...::.|...|:|
Frog   584 DLPSFKYYTACCFFIFACNFIVQILVSHKNAAFGISYGISF----FFFLLLLFTCFAGHLARCIL 644

  Fly   653 -------MLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFN 710
                   .||...:.:|.|    .::|....:...||:....|.::||.     .::...:..:|
Frog   645 KGPQLLHWLPSLSIALSSR----PWLRVPLGVFTILTVLVMAVFNLFFL-----PDNNCPQQSWN 700

  Fly   711 VTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLY--PSYLSNFGVLILIAIAVIAQL 773
              :||..|                           |..::||  |.|: ...:|.|:|.:....:
Frog   701 --SSLSPD---------------------------PEPQMLYSLPYYM-YCCILGLLACSAFLLM 735

  Fly   774 THLTKILLLLSIAALHCYFNIFIMQDLYALEDDF-------EHQPII--STRYAASGLLLVAALA 829
            ....| |:|||||.:  .:|:..::....|.|.:       ..:|.|  ..:...|..|.:....
Frog   736 NFEAK-LILLSIALV--IYNVIFLETHSWLSDCYVNWLYMNHSRPGILKEPKVMGSISLFIFFFT 797

  Fly   830 LSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYS 894
            |..|:|..::..|:.|.||.:...::|....|...|..|:.||||..||:.|:...:| ::|||.
Frog   798 LLALSRQNEYYCRLDFLWKRKFKMERERIETMENLNRVLLENVLPADVAQQFIGQNRR-NEDLYY 861

  Fly   895 QSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTY 959
            |||..|.|||||:|:|.:||:|...|::||||||.|||:|:|||.||..|:|..:.|||||||.|
Frog   862 QSYDCVCVLFASIPDFKEFYTECDENHEGLECLRLLNEIIADFDELLSKPKFSSVEKIKTIGSAY 926

  Fly   960 MAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGV 1024
            |||:|:|......|.......::|:.|:||||:.|...|..||:.|||:|.|::||||||:.|||
Frog   927 MAATGLNATSGQENPQDGDRNYNHIGIMVEFAIALIGKLDLINKHSFNNFKLRVGINHGPVVAGV 991

  Fly  1025 IGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGKGQLMTFY 1089
            |||:||.||||||||||||||:|||..|.|||||||..:|...||...:||::.|||||||.|::
Frog   992 IGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETTKVLEKLGYKCERRGVIKVKGKGQLCTYF 1056

  Fly  1090 LQGKSQSSAEPVASG 1104
            :      |.:...||
Frog  1057 V------STDMARSG 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	46/175 (26%)
		CYCc	256..453	CDD:214485	99/205 (48%)
		Guanylate_cyc	294..476	CDD:278633	95/181 (52%)
		CYCc	860..1071	CDD:214485	117/210 (56%)
		Guanylate_cyc	892..1092	CDD:278633	115/199 (58%)
adcy4	XP_002934331.3	AC_N	<17..250	CDD:318454	47/170 (28%)
		Guanylate_cyc	270..427	CDD:306677	85/156 (54%)
		DUF1053	483..586	CDD:399378	19/107 (18%)
		Guanylate_cyc	859..1057	CDD:306677	115/197 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910