Protein Alignment Ac3 and adcy1

DIOPT Version :9

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_002933461.1
• Gene: adcy1 / 100492373
• XenbaseID: XB-GENE-950909
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1116
• Identity: 366/1116 - (32%)
• Similarity: 586/1116 - (52%)
• Gaps: 186/1116 - (16%)

  Fly    54 LNELYHNYSIK-QRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVI-------NCCMLLAYLALT 110
            |..|:.||::| ::.|.||  ..|..:....|:.:....|.|:..|       :|.:.|:...:|
 Frog    43 LESLFQNYNLKLEQTSTLK--ALAVLIIMTGTLALLELMSGPSLTISKGSHPVHCIIFLSLFIVT 105

  Fly   111 ALLHIGRRSDKPALRRFHQILLIIVPRALWLLSILHFTVYVI----------LQPSFSPRDLLGW 165
            .:.::       .:.:..||:.:.:        :..||...:          |:|..|....|..
 Frog   106 NVKYL-------QVTQLQQIVKLTL--------LFGFTFSFLCCPFSLGAYGLEPPVSSEQGLWQ 155

  Fly   166 AILLNFLVYVTLPLQLIFLGLSIG---CITYFICLSLPVGYSHWDSLLSNQLAANAVLIATAALI 227
            .:|:.|:.|..||::.: |.:..|   .:::.|..:..:  |.....|...|..||:|..:..|.
 Frog   156 LMLVTFVAYALLPVRTL-LAIVFGFMVSVSHIIVTATSI--SPKKKRLWRTLVVNAILFVSVNLS 217

  Fly   228 GLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKHVAIKMREDLGSSSSEAFK 292
            |:....:.|..|::|||:|:..:|.::.:|:::.:|||||:|:||::||::|:||........|.
 Frog   218 GVFVRILTERAQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFH 282

  Fly   293 KIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCI 357
            |||:.||:|||||:|||||||:::|..:||:|||:|||||.:||.||.:....|||||||||||:
 Frog   283 KIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCV 347

  Fly   358 SGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKD 422
            ||....:.|||..||.|||.|:..|..|.:.....::||||:|||.||.|:||.|:||:||:|.|
 Frog   348 SGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSND 412

  Fly   423 VELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREELLRIAGLKTYFIT---------- 477
            |.|||.||:.|..|:|||:..||..|||::|||..:|.:|...|:...::|:||.
 Frog   413 VTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSFLKKHNIETFFIVPSHRRKIFPG 477

  Fly   478 ------KVVK--AFASPC--------AKKINETQAEIAHPNPNGSTTDIVSDEDDND---ATLDD 523
                  |..|  .|.:.|        .:|:  .:|||...|       :::.|||:.   .....
 Frog   478 LILSDIKPAKRMKFKTVCYLLVQLMHCRKM--FKAEIPFSN-------VMTCEDDDKRRALRTAS 533

  Fly   524 EELLAQNSVSNGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTN-IFLRFKNPQL 587
            |:|..::|.|..       ........::..:..||.:...|    ::...|.| |.|::|:.:.
 Frog   534 EKLRNRSSFSTN-------VIHNTPGTRVNRYIGRLIEARQT----DSEMSDLNFITLKYKHIER 587

  Fly   588 EQLYAVYREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIA---APLVPIAMLVVISLAES 649
            ||.|....:.|.:..::.:|::..:..|...|:.|:||:..|.:.   ..||...|.:.::..:.
 Frog   588 EQKYHQLHDEYFTSAVVLSLILAALFGLVYLLIFPQSTIVLILLVFCLCFLVACIMYLHVTRVQC 652

  Fly   650 FSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTAS 714
            |.|                           .|||....::.:|..:.      |.|.::..|...
 Frog   653 FPG---------------------------CLTIQIRTILCIFIVIL------IYSVAQGCVVGC 684

  Fly   715 L------ESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQL 773
            :      .:..::|:        :.|....:.|.:. |.:...| ::||  .|:..:::|:..::
 Frog   685 MPWIWRSNNSSSIVI--------ITPKGENKTMNER-PCDTAHY-TFLS--CVVGTLSLAIFLRI 737

  Fly   774 THLTKILLLLSIAALHCYFNIFIMQ----------DLYALEDDFEHQPIISTRYAASGLLLVAAL 828
            :...|::|||.:..|:    |.|::          |...:..   ::||::.      ||...:|
 Frog   738 SSFPKMVLLLFVTILY----IVILEISGYRKTLGGDTSYMRG---YEPILAI------LLFSCSL 789

  Fly   829 ALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLY 893
            ||.  :|.:|.:.|:.:.|..:..|:::....::..|:.:::|:||.|||:||:.:..|:. |||
 Frog   790 ALH--SRQVDLKLRLDYLWAVQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNM-DLY 851

  Fly   894 SQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGST 958
            .|||::|||:|||:|||:|||.|...||.|:||||.|||:|:|||.|:|...::||.||||||||
 Frog   852 YQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGST 916

  Fly   959 YMAASGINVQRTVRNDAPIT------ERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINH 1017
            ||.|.|:         .|.|      ..:|||:.|.:|::|:...|..||.||:|.|||::|||.
 Frog   917 YMGAVGL---------VPTTGTKAKKSIYSHLSTLADFSIEMFDVLDEINYQSYNEFVLRVGINV 972

  Fly  1018 GPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKGK 1082
            ||:.|||||||:|.||||||||||||||:|||..|.|||||:...||:...|.|:.||.|:||||
 Frog   973 GPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGK 1037

  Fly  1083 GQLMTFYLQGK 1093
            |:::|::|:||
 Frog  1038 GEMLTYFLEGK 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	45/170 (26%)
		CYCc	256..453	CDD:214485	106/196 (54%)
		Guanylate_cyc	294..476	CDD:278633	97/181 (54%)
		CYCc	860..1071	CDD:214485	115/216 (53%)
		Guanylate_cyc	892..1092	CDD:278633	115/205 (56%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	61/258 (24%)
		CYCc	248..443	CDD:214485	105/194 (54%)
		Guanylate_cyc	284..466	CDD:278633	97/181 (54%)
		CYCc	817..1028	CDD:214485	116/220 (53%)
		Guanylate_cyc	850..1047	CDD:278633	115/205 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910