DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and gucy1b1

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	724	Identity:	156/724 - (21%)
Similarity:	268/724 - (37%)	Gaps:	210/724 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 EFEVEAAFGEKREELLRIA--GLKTYFI----TKVVKAFASP------------CAKKINETQAE 497
            :.:.||...|:.:.|:||.  ..|||.:    |||:...|..            |.:...:|...
Frog    24 DIKKEAQLDEEGQFLVRIIYDDSKTYDLVSAATKVLNLNAGDILQMFGNMFFVFCQESGYDTILR 88

  Fly   498 IAHPNPNGSTTDIVSDEDD---------------NDATLDDEELLAQNSVSNGHQ---IGIAVTA 544
            :...|......::.:..|.               .||......:|...|...|.|   |||..|.
Frog    89 VLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIVKTV 153

  Fly   545 DEE---EQVKLENFKQR---------LKDELVTRDGHENLTKDTNIFLRF-KNPQLEQLYAVY-- 594
            .::   .::.::..:||         |.:|..||:  |:..:|.:   || :|...|...:.|
Frog   154 AQQIHGTEIDMKVIQQRNEECDHTQFLIEEKDTRE--EDFYEDQD---RFEENGTQESRISPYTF 213

  Fly   595 --REPYSSLPLLAALLVQCIDVLYSYLVLPR------STLHFINIAAPLVPIAMLVVISLAESFS 651
              ..|:..:......:.||.:.:|.  |||:      :.|...::..|.:.|          ||.
Frog   214 CKAFPFHIMFDRDLFVTQCGNAIYR--VLPQLQPGNCNLLSVFSLVRPHIDI----------SFH 266

  Fly   652 GMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLE 716
            |:|        ...|.:..:|....::                      :...||||..:|.:..
Frog   267 GIL--------SHINTVFVLRSKEGLL----------------------DVEKSESEDELTGTEI 301

  Fly   717 SDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLTHLTKILL 781
            |.:.|  :|.:.                          ||.....::.:....:..|..||:..|
Frog   302 SCLRL--KGQMI--------------------------YLPEADNILFLCSPSVMNLDDLTRRGL 338

  Fly   782 LLSIAALHCYFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFK 846
            .||...||     ...:||..|.:.|..:..::..             |..|...:.|..|.:
Frog   339 YLSDIPLH-----DATRDLVLLGEQFREEYKLTQE-------------LEILTDRLQHTLRAL-- 383

  Fly   847 WKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFS 911
                        .|.:::.:.|:|:|||..||     |..|....:.::.|..|.:||:.:..|:
Frog   384 ------------EDEKKKTDTLLYSVLPPSVA-----NELRHKRPVPAKRYDNVTILFSGIVGFN 431

  Fly   912 DFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAP 976
            .|.|:.......::.:..||::.:.||.|.:......:.|::|:|..||..||| .:..|.:...
Frog   432 TFCSKHASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGI-PEPCVHHARS 495

  Fly   977 ITERWSHLAI-LVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIGARKPHYDIWGNTVN 1040
            |    .|||: ::|.|.:::...:|:.        :.:||:.|.:..||||.|.|.|.::|||||
Frog   496 I----CHLALDMMEIAGQVQVDGESVQ--------ITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548

  Fly  1041 VASRMESTGKAGAIQVTEETCNILRLFGYTF--------------LQ-RGLVAVKGKGQLMTFYL 1090
            :.||.|:||:.|.|.|:|          ||:              || ||.|::|||...|..:.
Frog   549 LTSRTETTGEKGKINVSE----------YTYRCLMSPENSDPQFHLQYRGPVSMKGKTDPMQVWF 603

  Fly  1091 QGKSQSSAE 1099
            ..:..:..|
Frog   604 LSRKAAETE 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831
		CYCc	256..453	CDD:214485	0/1 (0%)
		Guanylate_cyc	294..476	CDD:278633	9/26 (35%)
		CYCc	860..1071	CDD:214485	63/211 (30%)
		Guanylate_cyc	892..1092	CDD:278633	63/215 (29%)
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902	27/141 (19%)
		HNOBA	207..406	CDD:369471	52/305 (17%)
		Guanylate_cyc	412..605	CDD:306677	63/215 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910