Protein Alignment Ac3 and adcy9

DIOPT Version :10

• Sequence 1: NP_610116.2
• Gene: Ac3 / 35419
• FlyBaseID: FBgn0023416
• Length: 1167
• Species: Drosophila melanogaster
• Sequence 2: XP_003201145.3
• Gene: adcy9 / 100333702
• ZFINID: ZDB-GENE-050208-455
• Length: 1392
• Species: Danio rerio
• Alignment Length: 1316
• Identity: 360/1316 - (27%)
• Similarity: 560/1316 - (42%)
• Gaps: 340/1316 - (25%)

  Fly    53 VLNELYHNYSIKQRRSGLKWFVF----AAALFNIWTIGIPWDQSAPTR-------VINCCMLLAY 106
            :|.|........|.:...::.:|    ||.|:.|: .||...:..||.       .:..|::|.:
Zfish   102 ILEEACRERCFPQMQRRFRYILFYLATAALLWGIY-FGINSSRCEPTNFLVPTAGFLILCLVLLW 165

  Fly   107 LALTALLHIGRRSDKPALRRFH--QILLIIVPRALWL---LSILHFTVY------------VILQ 154
            ...|          ||..|.::  ..||.::...:.|   ....||..|            |...
Zfish   166 FTFT----------KPYSRYYNHTSFLLTVIMFGITLAPQTQTAHFAHYDSHRADNQSPLPVYQN 220

  Fly   155 PS-FSPRDLLGWAILLNFLVYVTLPLQL---IFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLA 215
            .| .||.......:.:..|:|..|.|.|   :.|||      .:..|...:|:.|...|..:.:.
Zfish   221 ASCISPVGTFSLCMEVLLLLYSVLHLPLYASVLLGL------LYSVLYEALGWLHLAQLDESYVG 279

  Fly   216 ANAVLIAT--------------AALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERL 266
            :...:..|              |.::|:..:.|.|.:.:..||:..:::.....:|.:.|.:||:
Zfish   280 SREGISGTLSWLGPGKFLLHLCAHVVGIHIFIMSEVRSRSTFLKVGQAIMHGKDLEVEKALKERM 344

  Fly   267 LLSVLPKHVAIKMREDLGSSSSEA---------------------------------------FK 292
            :.||:|:.||.::.:. |...||:                                       |:
Zfish   345 IHSVMPRSVADELMKQ-GDEESESSGKRYSAGTCSVAAAAAVTSSSPKSHKRKKNSIPRGQIIFR 408

  Fly   293 KIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCI 357
            ...|.|.|.||||:|||||||.:|:..||..||.:||:||.|||||.|.....:|..|||||||:
Zfish   409 PFNMKRMEPVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCELTSCEKISTLGDCYYCV 473

  Fly   358 SGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKD 422
            :|.|:...|||..||.|||.|::||:...|:.:..|:||||:|||.||.||||.::::|||:|.|
Zfish   474 AGCPEPLTDHAYCCVEMGLGMIQAIEQFCQEMSETVNMRVGVHTGTVLCGILGMKRFKFDVWSND 538

  Fly   423 VELANKMESSGKAGRVHISDKTLAFLNGEFEVE-----AAFGEKREELLRIAGLKTYFITKVVKA 482
            |.|||.||..|.||:||:|:.|..||:..:|.|     ...|....:.|:  |||||.|:.  :.
Zfish   539 VNLANLMEQLGVAGKVHLSEVTAGFLDDRYEREDGRVIERVGHSVTDQLK--GLKTYLISG--RK 599

  Fly   483 FASPC-------AKKINE-------------TQAEIAHPNPNGS--------TTDIVSDEDDNDA 519
            ..|.|       .::..|             |...||.|..:|.        :.|:|.:...::|
Zfish   600 LGSQCGCSQLSLGQEFGETLSPSSNTHTPDHTHCAIAEPQSHGKAGFMPCSISIDVVDNPTTDEA 664

  Fly   520 TLD--DEELLAQNS---------VSNG-------HQIGIAVTA-----DEEEQ------------ 549
            |.:  .:|..|.:|         ..||       .::|::.::     .|:::
Zfish   665 TQNGCQDEHRANSSKFPAGRSPKALNGLLSPLCEERVGVSQSSLCDKLQEKDRSWAGSLAAEGKD 729

  Fly   550 ------VKLENFKQRLKDELVTRDGHENLTKD-------TNIFLRFKNPQLEQLYAV-YRE---- 596
                  ::.:||:::.....|.....::|.||       ..:.|.|....||..|.. |.|
Zfish   730 HSAILPLRSKNFREKSDAHFVEVIKEDSLMKDYFFKPPINKLSLNFLEKSLESAYRTSYHEQVMN 794

  Fly   597 --PYSSL--PLLAALLVQCIDVLYSYLVLPRSTL-----HFINIAAPL-------VPIAMLVVIS 645
              |..:.  |:.::||    |||.|..|....|:     ..:::..||       :..|:|.::|
Zfish   795 HVPVQTFASPVFSSLL----DVLLSCTVFLALTMACFLYPLVSMQTPLAATLGLAITAALLELVS 855

  Fly   646 LAESF--------------------SGMLPKFFVD---VS----KRFNDITFVRELAAIIIALTI 683
            |..|.                    ||.:|:..:.   ||    ..|:.:.:..:| .|.:.:.:
Zfish   856 LLLSIRMIFCLDDVQNCSRILLKLVSGWVPRHVIGAVLVSLPAVSVFSHLAYSLQL-PIQVTMFL 919

  Fly   684 GFSNVIDMFFFVTFVRTEHIVSESEFNVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTE 748
            ..:.:|.:..:.||       .:..|.:.::|.:     |.|:.....|..||......||
Zfish   920 CCALIIAIIQYCTF-------CQLSFWMRSALAT-----VVGLSLLILLYSASIRTSATDA---- 968

  Fly   749 RVLYPSY--LSNFGVLILIAIAVIAQLTHLTKILLLLSIAALHCYFNIFIMQDLYALEDDFEHQP 811
               :|.:  :||...    .:.::.:.......|.||.:..:..:|.:.::  ::.|..:||
Zfish   969 ---FPGFGNMSNQSA----QVDLLGESNSAPTALDLLVLETVLSFFLLLLL--VWFLNREFE--- 1021

  Fly   812 IISTRYAASGLLLVAALALSTLARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVH 876
             :|.|....|                          ..|..:.:.....||.:.:.|:.|::|:|
Zfish  1022 -VSYRLHYHG--------------------------NVEADKHRIKIQTMRDQADWLLRNIIPIH 1059

  Fly   877 VAEHFMKNTKRSHDDLYSQSYAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALL 941
            |||....|..      ||:::..|||:|||:.|||:||.|.  ...|.||.|.|||:|.|||.||
Zfish  1060 VAEQLKVNQS------YSKNHDNVGVIFASIVNFSEFYEES--YEGGKECYRVLNELIGDFDELL 1116

  Fly   942 ELPQFQDIIKIKTIGSTYMAASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSF 1006
            ..|.|.::.||||||:|||||||:|.|:......|    .:||..|.:||||:...:...|:...
Zfish  1117 RQPAFSNVEKIKTIGATYMAASGLNGQQCQEQPHP----HAHLCALFDFALEMMRVVDDFNKNML 1177

  Fly  1007 N-HFVLKMGINHGPITAGVIGARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYT 1070
            . .|.|::|.||||:||||||..|..|||||:|||:||||:|||....|||:||:..:|....|.
Zfish  1178 GFKFKLRIGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDSTGVECRIQVSEESHCVLSRMNYA 1242

  Fly  1071 FLQRGLVAVKGKGQLMTFYL-------QGKSQS-------SAEPVASGVVVLNGQDSSAVESTSE 1121
            |..||.|.||||||:.|:..       .|.:||       |.||            |:...:|:.
Zfish  1243 FDYRGTVNVKGKGQMRTYLFPQMNEGGMGSTQSLEQGQVDSLEP------------STLANTTTP 1295

  Fly  1122 LEASDIKMPLLKMNGP 1137
            ..|:.:..|   .|.|
Zfish  1296 THAAPLIPP---SNSP 1308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AcyC	122..455	CDD:441717	130/406 (32%)
		Guanylate_cyc	294..476	CDD:425528	94/186 (51%)
		Guanylate_cyc	892..1092	CDD:425528	100/207 (48%)
adcy9	XP_003201145.3	None