DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ac3 and adcy8

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1248	Identity:	400/1248 - (32%)
Similarity:	616/1248 - (49%)	Gaps:	222/1248 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ASTSKSHSQ--------RQTTSRRRQN------------------------DSDVAGGVGITGGG 45
            ||..::|:|        |.:.|.|..|                        :||.....|.|..|
Zfish    61 ASPDEAHTQGSRKHSAGRTSVSDRHNNGGTKVFPERSSSDLGFLQIDCAPSNSDFFLSWGYTYRG 125

  Fly    46 VVI------LPQHVLNELYHNYSIKQRRSGLKWFVFAAALFNIWTIGIPWDQSAPTRVINCCMLL 104
            |:.      .....|..||..|.:.|||.       :..:.||..:           |....:|:
Zfish   126 VIFPTLRYAFKSRDLERLYQRYFLGQRRK-------SVVVMNILDV-----------VTKLTLLV 172

  Fly   105 AYLAL--TALLHIGRRSDKPALRRFHQ-----ILLIIVPR--------------ALWLLSILHFT 148
            .:|.|  |.:..|     |..|..|..     |..::|.|              ..|:.......
Zfish   173 LHLTLASTPMDPI-----KGMLLGFFTGIEVVICALVVVRKDTSSHGYLQYSGAVTWVAMATQIL 232

  Fly   149 V----YVILQPSFSPRDLLGWAILLNFLVYVTLPLQLIFLGLSIGCITYFICLSLPVGYSHWDSL 209
            .    |.:|      .|.:|:.:...|..|..|||.|.: .:..|.:|..:.::|.:.......:
Zfish   233 ATGLGYGLL------GDGIGYVLFTLFATYSMLPLPLTW-AIVAGLLTSALHIALQLLVPPRAQI 290

  Fly   210 LSNQLAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKMVIEEQSAEQERLLLSVLPKH 274
            .:|||.|..:|.......|:...::.:..|::||||.::.:|.::.:|.::..||||:|||||:.
Zfish   291 STNQLLAQVLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRF 355

  Fly   275 VAIKMREDLGSSSSEA----FKKIYMSRHENVSILYADIVGFTAISSTYSAQDLVKMLNELFARF 335
            |.::|..|:.:...|.    |.:||:.|:||||||:||:.|||.:|:|.|||:||:|||||||||
Zfish   356 VVLEMINDMTNVEDETLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARF 420

  Fly   336 DRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIH 400
            ||||.::..||||||||||||:||.|:.|||||..||.|||||:|.|:||:.:....:|||:|||
Zfish   421 DRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIH 485

  Fly   401 TGAVLAGILGQRQWQFDVYSKDVELANKMESSGKAGRVHISDKTLAFLNGEFEVEAAFGEKREEL 465
            :|:||.|:||.|:|||||:|.||::|||:||.|..||:|||...|..|||::|||...|:.|.:.
Zfish   486 SGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKAALDCLNGDYEVEEGHGKDRNDF 550

  Fly   466 LRIAGLKTYFITKVVKAFASPCAKKINETQAEIAHPNPNGSTTD-----------IVSDEDDNDA 519
            ||...::|:.|.:..::..:.....:.::..:..|...|.|.|:           ||..::...|
Zfish   551 LRRHNIETFLIKQPEESLLTLPEDIMRDSTNQSDHRTSNTSFTEGTWSPELPFHNIVGKQNTLAA 615

  Fly   520 TLDDEELLAQNSVS---NGHQIGIAVTADEEEQVKLENFKQRLKDELVTRDGHENLTKDTNIF-L 580
                   |.::|::   |.....:.|.|..:|      ...|::..:..|.|.:...:..:.| |
Zfish   616 -------LTRHSINLLPNHLAQALHVRAGSQE------INARMQSTIALRSGDKLRQEHISPFSL 667

  Fly   581 RFKNPQLEQLYAVYR-EPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVI 644
            .|:...||..|:..| |.:.|..:.|.:::..|..:.|.|...|.....|..:..::....|||:
Zfish   668 TFREALLEHKYSQMRDEVFKSNLVCAFIVLFFITGIQSLLPSARMVTMLIQFSVLILLHCCLVVV 732

  Fly   645 SLAESFSGMLPKFFVDVSKRFNDITFVRELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEF 709
            :.||.:. .||..........|: |:......|.:::.|.|...:....:..|.::....::: |
Zfish   733 TTAEDYK-CLPLVLRKACCWVNE-TYAARNVVIFLSILINFLAAMINILWCDFDKSGSFRNQT-F 794

  Fly   710 NVTASLESDINLVVEGMVTAEHLLPASFVEQMRDAVPTERVLYPSYLSNFGVLILIAIAVIAQLT 774
            |.:||: .||                              ..||.|....|||.::..||..:|.
Zfish   795 NASASI-PDI------------------------------CFYPEYFVFTGVLAMVTCAVFLRLN 828

  Fly   775 HLTKILLLLSIAALHC------YFNIFIMQDLYALEDDFEHQPIISTRYAASGLLLVAALALSTL 833
            .:.|:.:||.:.|::.      |..:||..|...|.   :.:..:.|:  .:.|||:|...|:..
Zfish   829 SVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLN---QSKSFLGTK--ETSLLLMAMFLLAVF 888

  Fly   834 --ARHMDHEDRVIFKWKTEVAEQKETANDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQS 896
              .:.:::..|:.|.|:.:..|:.....::|:.||.::.|:||.|||.||::. .|.:::|||||
Zfish   889 YHGQQLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEK-DRDNEELYSQS 952

  Fly   897 YAEVGVLFASMPNFSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYMA 961
            |..|||:|||:|.|:||||:..:||||:||||.|||:|:|||.||...:||||.|||||||||||
Zfish   953 YDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIKTIGSTYMA 1017

  Fly   962 ASGINVQRTVRNDAPITERWSHLAILVEFALELKHALQSINEQSFNHFVLKMGINHGPITAGVIG 1026
            .||::.::....|     :|.||..|.:||:.|..::|.||:.|||:|.|::|:.||.:.|||||
Zfish  1018 VSGLSPEKQQCED-----KWGHLCALADFAIALNESIQEINKHSFNNFQLRIGMAHGSVVAGVIG 1077

  Fly  1027 ARKPHYDIWGNTVNVASRMESTGKAGAIQVTEETCNILRLFGYTFLQRGLVAVKG----KGQLMT 1087
            |:||.|||||.|||:||||:|||.:|.||:.|||..||...|:.|..||.:.|||    :|::.|
Zfish  1078 AKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKGISEQEGKIRT 1142

  Fly  1088 FYLQGK--------------SQSSAEPVASGVV----------VLNGQDSSAV------------ 1116
            .::.|:              .|.|...|..|:|          :||..::|.:
Zfish  1143 HFMIGRVQPNPLILQPRKLTGQYSLAAVVLGLVQSLNRQKQKQILNENNNSGIMKGHYNRRTLLA 1207

  Fly  1117 ---ESTSELEASD 1126
               ..||..|.:|
Zfish  1208 PGGSDTSHAEVTD 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	43/180 (24%)
		CYCc	256..453	CDD:214485	116/200 (58%)
		Guanylate_cyc	294..476	CDD:278633	109/181 (60%)
		CYCc	860..1071	CDD:214485	115/210 (55%)
		Guanylate_cyc	892..1092	CDD:278633	111/203 (55%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	61/268 (23%)
		CYCc	340..538	CDD:214485	115/197 (58%)
		Guanylate_cyc	379..563	CDD:278633	110/183 (60%)
		DUF1053	592..685	CDD:283888	20/105 (19%)
		CYCc	919..1123	CDD:214485	115/209 (55%)
		Guanylate_cyc	948..1147	CDD:278633	111/203 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810