DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ac3 and gucy1a2

DIOPT Version :9

Sequence 1:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	414	Identity:	109/414 - (26%)
Similarity:	181/414 - (43%)	Gaps:	88/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 RFHQILLIIVPR-------ALWLLSILHFTVYVILQ----PSFSPRDLLGWAILLNFLVYVTLPL 179
            :||....|:.|:       .|..||    |.:||..    |:|..:|.:  ..:...::||....
Frog   339 QFHDSFEIVSPKISCTFEQVLLRLS----TPFVIRNKPDAPTFENKDKV--MEVKGQMIYVPESS 397

  Fly   180 QLIFLGLSIGCITYFICLSLPVGYSHWDSLLSNQLAANAVLI--ATAALIGLLYYFMGEAKQKRA 242
            .::|||              .......|.|:...|..:.:.|  ||..:|     .:||  |.:|
Frog   398 SILFLG--------------SPRVDKLDELMGRGLHLSDIPIHDATRDVI-----LVGE--QAKA 441

  Fly   243 FLEAKKSLE-VKMVIEE--QSAEQER-----LLLSVLPKHVAIKMREDLGSSSSEAFKKIYMSRH 299
            ....||.:: :|..:|:  |:.|:|:     ||.|:.|..||.::.|.         |.:...:.
Frog   442 QDGLKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWEG---------KSVQARKF 497

  Fly   300 ENVSILYADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDER 364
            ::|::|::|||||||:.:..:...::.|||||:.|||.........:::.:||.|...:|...:.
Frog   498 DDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGLLRQS 562

  Fly   365 PDHAVLCVHMGLSMVKAIKYVQQKANSPVDMRVGIHTGAVLAGILGQRQWQFDVYSKDVELANKM 429
            ..||.....|.|.|::..:.|......|:.||:|||:|:||||::|.|..::.::..:|.||:|.
Frog   563 NSHAKPIALMALKMMELSEEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKF 627

  Fly   430 ESSGKAGRVHISDKTLAFLNGEFEVEAAF---GEKREEL-----LRIAGLKTYFITKVVKAFASP 486
            ||.....|:::|..|...|..    ||.|   ...||||     ..|.|: .||:
Frog   628 ESGSHPRRINVSPTTYQLLKD----EANFHFVPRSREELPDNFPKEIPGI-CYFL---------- 677

  Fly   487 CAKKINETQAEIAHPNPNGSTTDI 510
                    :|:.....|..|.|.:
Frog   678 --------EADSGQKQPKPSLTSV 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	43/178 (24%)
		CYCc	256..453	CDD:214485	62/203 (31%)
		Guanylate_cyc	294..476	CDD:278633	60/189 (32%)
		CYCc	860..1071	CDD:214485
		Guanylate_cyc	892..1092	CDD:278633
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902
		HNOBA	296..486	CDD:369471	42/173 (24%)
		Guanylate_cyc	492..679	CDD:306677	61/209 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910