DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompB and IFT88

DIOPT Version :9

Sequence 1:	NP_724347.3	Gene:	nompB / 35414	FlyBaseID:	FBgn0016919	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_001305422.1	Gene:	IFT88 / 8100	HGNCID:	20606	Length:	833	Species:	Homo sapiens

Alignment Length:	890	Identity:	299/890 - (33%)
Similarity:	443/890 - (49%)	Gaps:	175/890 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PPPTA----AGRPRPPTSQLFSRGNLASS---RATGGDKSGLARPSTAVRAVGY--AANCESAHQ 81
            ||.||    ....||..:...|:.:||||   ..||..:.|:.||.|||||.|:  ||...||
Human    59 PPITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSA-- 121

  Fly    82 RFEQFFLEKAKQQTLSSRAAVDAIKDVNPQMKYKNLEEKIVKLLESSIVLAWQGSPNKLLNLDTK 146
             |:..      .|:....:.::|.|..:|:.|.|.||:::.:|:|.|.:....|        |.|
Human   122 -FDPL------SQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCG--------DLK 171

  Fly   147 LAEALSKAKEAFSLDRTLHQFRDQ--HGENVYHNFDLTY-------AQYERSEMHIEALNTYSIM 202
            |  ||.|||:|...:|.|.:.|:|  ..||:  |.||||       :||..:||:.||||||.::
Human   172 L--ALEKAKDAGRKERVLVRQREQVTTPENI--NLDLTYSVLFNLASQYSVNEMYAEALNTYQVI 232

  Fly   203 AKNKMFPHVNQLKLNMGNIYYSMGIYQKAVKMYRMALDSVPKSLSQLRLKIRENIGILFIRMGSY 267
            .|||||.:...||:||||||.....|.||:|.||||||.||....|:|:||.:|||:.||:.|.|
Human   233 VKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQY 297

  Fly   268 SDAASSFEFIMTERANIRSSIHLLLCYFALGDVEKVKLAFRRLCDVQTEAIESDMESETNIIKLQ 332
            |||.:|:|.||:...|:::..:|.:||||:||.||:|.||::|..|..|..|
Human   298 SDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDE------------- 349

  Fly   333 QQAEPIQQIGETDGYQSLNNEPVTGSVIKAEGGGKLNETVKFAATVKHRYVVQALKKDELAVYRN 397
                        |.|.|.:::|.|                        ..|.:|:|.|.|.....
Human   350 ------------DKYISPSDDPHT------------------------NLVTEAIKNDHLRQMER 378

  Fly   398 ERRNAVKRSITMIVDLISPFIEDNYNDGYNWCIEIIKTSNLAWLANELELNKALVYLRQNDVHQA 462
            ||:...::.|.....||:|.||.::..||:||:|::|.|....|||:||:|||:.||||.|.:||
Human   379 ERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYNQA 443

  Fly   463 IETLQMYDRKSEGSMTASALTNLSFIYI---------KMASHCVNQLHEIGSLKNNAPGLINAGI 518
            :|.|::.::| :..:.::|.||||.:|.         ..|...||      |.:.|...|.|.|.
Human   444 VEILKVLEKK-DSRVKSAAATNLSALYYMGKDFAQASSYADIAVN------SDRYNPAALTNKGN 501

  Fly   519 VELGSHNLILASERFEGALQLQPMNFEARYNLGLVALAQNDYELAEERFELLKEQLMLPSSVQHS 583
            ....:.:...|:|.::.||:......||.||:||.....|..:.|.:.|  ||...:|.:|.:
Human   502 TVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCF--LKLHAILRNSAE-- 562

  Fly   584 HVFYQLAKLQERRLESGLISNFTPGAALQAYLQVVGISASDIDSRLFEKVGSLYEQIQDHQEANQ 648
             |.||:|.:.|      |:.|  |..|::..:|||.:..:  |.::..|:|.||::..|..:|.|
Human   563 -VLYQIANIYE------LMEN--PSQAIEWLMQVVSVIPT--DPQVLSKLGELYDREGDKSQAFQ 616

  Fly   649 YYNEAYRINMSDIGIASSIGSYYIKLQATERALFYYERAVLADPNDPNLMLRIASCFRNS--YLP 711
            ||.|:||....:|.:...:|:|||..|..|:|:.|:|||.|..|......|.:|||||.|  |
Human   617 YYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNY-- 679

  Fly   712 TKQYLGLFQKIHARFPDNLTCIRALMQVTKSLELGDLYERYASEYTRLQSQQQERQSEQRYQQ-- 774
             ::.|..::..|.:||:|:.|:|.|:::...|.|.|..| ||.:..||:..::.|  |||.:.
Human   680 -QKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQE-YARKLKRLEKMKEIR--EQRIKSGR 740

  Fly   775 -------------------QRFPSAAK---FSNRLRSIRQSNEEH----LKEVGENFNSVVHTQS 813
                               |.:.:::|   .|.|||::..:||.:    .||:..::
Human   741 DGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSSNKEIDASY-------- 797

  Fly   814 PYTSILQFDPLGPPAERPKTGRPLQSRDDVDD--DAEMNPESLLP 856
                   .|||||..|||||.  .:.|.|.||  |.|:. :.|||
Human   798 -------VDPLGPQIERPKTA--AKKRIDEDDFADEELG-DDLLP 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompB	NP_724347.3	TPR_11	213..275	CDD:290150	35/61 (57%)
		TPR repeat	213..240	CDD:276809	16/26 (62%)
		TPR	216..244	CDD:197478	17/27 (63%)
		TPR repeat	245..279	CDD:276809	17/33 (52%)
		TPR repeat	284..309	CDD:276809	12/24 (50%)
		TPR repeat	479..502	CDD:276809	9/31 (29%)
		TPR repeat	509..539	CDD:276809	8/29 (28%)
		TPR_16	<529..568	CDD:290168	12/38 (32%)
		TPR repeat	544..568	CDD:276809	8/23 (35%)
		TPR_11	626..692	CDD:290150	26/65 (40%)
		TPR repeat	627..655	CDD:276809	10/27 (37%)
		TPR repeat	660..690	CDD:276809	12/29 (41%)
IFT88	NP_001305422.1	TPR repeat	206..234	CDD:276809	11/27 (41%)
		TPR_11	<222..>730	CDD:330823	203/582 (35%)
		TPR repeat	247..270	CDD:276809	14/22 (64%)
		TPR repeat	280..310	CDD:276809	17/29 (59%)
		TPR repeat	314..341	CDD:276809	12/26 (46%)
		TPR repeat	428..451	CDD:276809	12/22 (55%)
		TPR repeat	461..487	CDD:276809	7/25 (28%)
		TPR repeat	493..521	CDD:276809	6/27 (22%)
		TPR repeat	526..556	CDD:276809	11/31 (35%)
		TPR repeat	561..589	CDD:276809	11/38 (29%)
		TPR repeat	595..623	CDD:276809	10/27 (37%)
		TPR repeat	629..655	CDD:276809	10/25 (40%)
		TPR repeat	663..687	CDD:276809	9/26 (35%)
		TPR repeat	697..724	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6443
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4761
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2101
Isobase	1	0.950	-	0	Normalized mean entropy	S3680
OMA	1	1.010	-	-		QHG56319
OrthoDB	1	1.010	-	-		D137383at33208
OrthoFinder	1	1.000	-	-		FOG0007391
OrthoInspector	1	1.000	-	-		oto89580
orthoMCL	1	0.900	-	-		OOG6_103642
Panther	1	1.100	-	-	LDO	PTHR44117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5514
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.930