DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompB and ift88

DIOPT Version :9

Sequence 1:	NP_724347.3	Gene:	nompB / 35414	FlyBaseID:	FBgn0016919	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	XP_021334279.1	Gene:	ift88 / 321855	ZFINID:	ZDB-GENE-030131-574	Length:	872	Species:	Danio rerio

Alignment Length:	927	Identity:	288/927 - (31%)
Similarity:	445/927 - (48%)	Gaps:	186/927 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SEHEAVPPP----PPTAAGRPRPPTSQLFSR---GNLASSRATGGDKSGLARPSTAVRAVGYAAN 75
            :.|...||.    |.||.| .||..:...||   |.......||..:.|.|||.|||||.||:::
Zfish    43 TSHGRRPPMTAKYPGTAIG-GRPIGTAYGSRVPIGTAMGRPMTGAVQDGAARPMTAVRAAGYSSS 106

  Fly    76 CESAHQRFEQFFLEKAKQQTLSSRAAVDAIKDVNPQMKYKNLEEKIVKLLESSIVLAWQGSPNKL 140
            . :....|:.....|.....|.::      .:..|:.|.|.||:|:..|:|.|.:...:|.
Zfish   107 I-ARGSAFDPLGQAKGPAPPLETK------NEDTPEEKIKILEKKVNDLIEDSCLAHARGD---- 160

  Fly   141 LNLDTKLAEALSKAKEAFSLDRTLHQFRDQHGENVYHNFDLTYA-------QYERSEMHIEALNT 198
                  |..:|.|||||...:|.|.:.|:|.|...:.|.||||:       ||..::|:.|||||
Zfish   161 ------LQVSLEKAKEAGRKERALVRQREQTGTADHINLDLTYSVLFNLANQYANNDMYTEALNT 219

  Fly   199 YSIMAKNKMFPHVNQLKLNMGNIYYSMGIYQKAVKMYRMALDSVPKSLSQLRLKIRENIGILFIR 263
            |.::.|||||.:..:||:||.|||:....|.||:|.||||||.:..:.:.:|:||.:|||::||.
Zfish   220 YQVIVKNKMFNNAGRLKVNMANIYFKQKNYTKAIKFYRMALDQISNAHNAMRIKIMQNIGVVFIH 284

  Fly   264 MGSYSDAASSFEFIMTERANIRSSIHLLLCYFALGDVEKVKLAFRRLCDVQTEAIESDMESETNI 328
            ||.||||.:|||:||||..||::..:|:|||:|:||.|::|.||::|..|
Zfish   285 MGQYSDAITSFEYIMTESPNIKTGFNLILCYYAIGDRERMKKAFQKLICV--------------- 334

  Fly   329 IKLQQQAEPIQQIGETDGYQSLNNEPVTGSVIKAEGGGKLNETVKFAATVKHRYVVQALKKDELA 393
                    |: .:.:.|.|...|::|....||                        :|:|.|:|.
Zfish   335 --------PL-GVDDDDKYIPPNDDPHANMVI------------------------EAIKNDKLH 366

  Fly   394 VYRNERRNAVKRSITMIVDLISPFIEDNYNDGYNWCIEIIKTSNLAWLANELELNKALVYLRQND 458
            ....||:...::.|.....||:|.||.::..|::||::::|.|....|||:||:|||:.||||.|
Zfish   367 QMERERKALAEKYIMTSAKLIAPAIEMSFAAGFDWCVDMVKGSQYVELANDLEINKAITYLRQRD 431

  Fly   459 VHQ--AIETLQMYDRKSEGSMTASALTNLSFIYIKMASHCVNQLHEIGSL-----KNNAPGLINA 516
            ..|  |:|||:|:::| :..:.::|.|||||:|  ......:|......|     :.|...|||.
Zfish   432 FKQAEAVETLKMFEKK-DSRVKSAAATNLSFLY--FLEKDFDQADRYAELAMSADRYNPAALINK 493

  Fly   517 GIVELGSHNLILASERFEGALQLQPMNF-------EARYNLGLVALAQNDYELAEERFELLKEQL 574
            |       |.:...|.:|.|.:....:.       ||.|||||........|.|.:.|  ||...
Zfish   494 G-------NTLFVKEDYEKAAEFYKESLRNDSSCTEALYNLGLTYKRLGRLEEALDCF--LKLHA 549

  Fly   575 MLPSSVQHSHVFYQLAKLQERRLESGLISNFTPGAALQAYLQVVGISASDIDSRLFEKVGSLYEQ 639
            :|.:|.|   |.||||.|.| .||.       |..|::..:|:..::.:  |:::..|:|.||:.
Zfish   550 ILRNSAQ---VMYQLANLYE-MLED-------PHQAIEWLMQLTSVTPT--DAQVLAKLGDLYDN 601

  Fly   640 IQDHQEANQYYNEAYRINMSDIGIASSIGSYYIKLQATERALFYYERAVLADPNDPNLMLRIASC 704
            ..|..:|.|||.|:||...|:|.:...:|:|||..|..|:|:.|:|||.|..|......|.:|||
Zfish   602 EGDKSQAFQYYYESYRYFPSNISVIEWLGAYYIDTQFCEKAIQYFERATLIQPTQVKWQLMVASC 666

  Fly   705 FRNS--YLPTKQYLGLFQKIHARFPDNLTCIRALMQVTKSLELGDLYERYASEYTRLQSQQQERQ 767
            :|.|  |   ::.|..:::||.:||:|:.|:|.|:::...:.|.::.: ||::..:::..::.|
Zfish   667 YRRSGNY---QKALETYKEIHRKFPENVECLRFLVRLCTDMGLKEVQD-YATKLKKVEKMKEIR- 726

  Fly   768 SEQRYQQQRFPSA---------------------------------------------AKFSNRL 787
             |||.:..|..||                                             .|:|..|
Zfish   727 -EQRVRSGRDSSARSRREGSAGSGNTSNLTHTPPKKASGSSSSPINTPPLRASVSRSEVKYSPVL 790

  Fly   788 RSIRQSNEEH------LKEVGENFNSVVHTQSPYTSILQ-------FDPLGPPAERPKTGRPLQS 839
            ...|.|.:.:      .:.:.....::..:..||.:..|       .|||||..:||||....::
Zfish   791 EQSRDSGQSNHGTSAKSERLSVKLKTLPGSNEPYEASTQQEIDASYVDPLGPQTQRPKTAARKRN 855

  Fly   840 RDDVDDDAEMNPESLLP 856
            .:|...|.|:. :.|||
Zfish   856 EEDEFADEELG-DDLLP 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompB	NP_724347.3	TPR_11	213..275	CDD:290150	32/61 (52%)
		TPR repeat	213..240	CDD:276809	15/26 (58%)
		TPR	216..244	CDD:197478	15/27 (56%)
		TPR repeat	245..279	CDD:276809	18/33 (55%)
		TPR repeat	284..309	CDD:276809	12/24 (50%)
		TPR repeat	479..502	CDD:276809	8/22 (36%)
		TPR repeat	509..539	CDD:276809	9/29 (31%)
		TPR_16	<529..568	CDD:290168	12/45 (27%)
		TPR repeat	544..568	CDD:276809	9/30 (30%)
		TPR_11	626..692	CDD:290150	27/65 (42%)
		TPR repeat	627..655	CDD:276809	10/27 (37%)
		TPR repeat	660..690	CDD:276809	12/29 (41%)
ift88	XP_021334279.1	TPR repeat	197..225	CDD:276809	10/27 (37%)
		TPR_11	<213..>700	CDD:330823	197/562 (35%)
		TPR repeat	238..261	CDD:276809	13/22 (59%)
		TPR repeat	271..301	CDD:276809	19/29 (66%)
		TPR repeat	305..332	CDD:276809	12/26 (46%)
		TPR repeat	455..481	CDD:276809	9/27 (33%)
		TPR repeat	487..515	CDD:276809	8/34 (24%)
		TPR repeat	520..550	CDD:276809	12/31 (39%)
		TPR repeat	555..580	CDD:276809	12/35 (34%)
		TPR repeat	589..617	CDD:276809	10/27 (37%)
		TPR repeat	622..652	CDD:276809	12/29 (41%)
		TPR repeat	657..682	CDD:276809	8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5954
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4761
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2056
OMA	1	1.010	-	-		QHG56319
OrthoDB	1	1.010	-	-		D137383at33208
OrthoFinder	1	1.000	-	-		FOG0007391
OrthoInspector	1	1.000	-	-		oto39551
orthoMCL	1	0.900	-	-		OOG6_103642
Panther	1	1.100	-	-	LDO	PTHR44117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6827
SonicParanoid	1	1.000	-	-		X5514
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010