DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nompB and Ift88

DIOPT Version :9

Sequence 1:	NP_724347.3	Gene:	nompB / 35414	FlyBaseID:	FBgn0016919	Length:	857	Species:	Drosophila melanogaster
Sequence 2:	NP_033402.2	Gene:	Ift88 / 21821	MGIID:	98715	Length:	825	Species:	Mus musculus

Alignment Length:	896	Identity:	302/896 - (33%)
Similarity:	451/896 - (50%)	Gaps:	143/896 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ANGTQRLPEPVSEHEAVPPP----PPTAAGRP-----RPPTSQLFSRGNLASSRA---TGGDKSG 59
            |..|:.|.......:||...    ||..|..|     ||..:...|:.:|.||..   ||..:.|
Mouse    26 AYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDG 90

  Fly    60 LARPSTAVRAVGYAANCESAHQRFEQFFLEKAKQQTLSSRAAVDAIKDVNPQMKYKNLEEKIVKL 124
            :|||.|||||.|::    .|..|...|   ....|:......::|..:.:|:.|.:.||:|:.:|
Mouse    91 VARPMTAVRAAGFS----KAALRGSAF---DPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNEL 148

  Fly   125 LESSIVLAWQGSPNKLLNLDTKLAEALSKAKEAFSLDRTLHQFRDQ--HGENVYHNFDLTY---- 183
            :|.|.:....|        |.||  ||.|||:|...:|.|.:.|:|  ..||:  |.||||
Mouse   149 VEESCIANSCG--------DLKL--ALEKAKDAGRKERVLVRQREQVTSPENI--NLDLTYSVLF 201

  Fly   184 ---AQYERSEMHIEALNTYSIMAKNKMFPHVNQLKLNMGNIYYSMGIYQKAVKMYRMALDSVPKS 245
               :||..:||:.||||||.::.|||||.:..:||:||||||.....|.||:|.||||||.:|..
Mouse   202 NLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSV 266

  Fly   246 LSQLRLKIRENIGILFIRMGSYSDAASSFEFIMTERANIRSSIHLLLCYFALGDVEKVKLAFRRL 310
            ..::|:||.:||||.||:.|.||||.:|||.||:...::::..:|:|..||:||.||:|.||::|
Mouse   267 HKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKL 331

  Fly   311 CDVQTEAIESDMESETNIIKLQQQAEPIQQIGETDGYQSLNNEPVTGSVIKAEGGGKLNETVKFA 375
            ..|..|                        |.|.|.|.|.:::|.|
Mouse   332 IAVPLE------------------------IDEDDKYISPSDDPHT------------------- 353

  Fly   376 ATVKHRYVVQALKKDELAVYRNERRNAVKRSITMIVDLISPFIEDNYNDGYNWCIEIIKTSNLAW 440
                 ..:::|:|.|.|.....||:...::.|.....||:|.||.::..|||||:|::|.|....
Mouse   354 -----NLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVE 413

  Fly   441 LANELELNKALVYLRQNDVHQAIETLQMYDRKSEGSMTASALTNLSFIYIKMASHCVNQLHE--- 502
            |||:||:|||:.||||.|.:||::||:|:::| :..:.::|.|||||:|     :..|:..:
Mouse   414 LANDLEINKAITYLRQKDFNQAVDTLKMFEKK-DSRVKSAAATNLSFLY-----YLENEFAQASS 472

  Fly   503 -----IGSLKNNAPGLINAGIVELGSHNLILASERFEGALQLQPMNFEARYNLGLVALAQNDYEL 562
                 :.|.:.|...|.|.|.....:.:...|:|.::.||:......||.||:||.....|..:.
Mouse   473 YADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDE 537

  Fly   563 AEERFELLKEQLMLPSSVQHSHVFYQLAKLQERRLESGLISNFTPGAALQAYLQVVGISASDIDS 627
            |.:.|  ||...:|.:|.|   |..|:|.:.|      |:.:  |..|::..:|:  ||....||
Mouse   538 ALDSF--LKLHAILRNSAQ---VLCQIANIYE------LMED--PNQAIEWLMQL--ISVVPTDS 587

  Fly   628 RLFEKVGSLYEQIQDHQEANQYYNEAYRINMSDIGIASSIGSYYIKLQATERALFYYERAVLADP 692
            :...|:|.||:...|..:|.|||.|:||...|:|.:...:|:|||..|..|:|:.|:|||.|..|
Mouse   588 QALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQP 652

  Fly   693 NDPNLMLRIASCFRNS--YLPTKQYLGLFQKIHARFPDNLTCIRALMQVTKSLELGDLYERYASE 755
            ......|.:|||||.|  |   ::.|..:::||.:||:|:.|:|.|:::...:.|.::.| ||::
Mouse   653 TQVKWQLMVASCFRRSGNY---QKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQE-YATK 713

  Fly   756 YTRLQSQQQERQSEQRYQQQRFPSAAKFSNRLRSI----RQSNEEHLK--EVGENFNSVVHTQSP 814
            ..||:..::.|  |||.:..|..|....|.|..|.    .|:|....|  .:.....::..|..|
Mouse   714 LKRLEKMKEMR--EQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEP 776

  Fly   815 YTS-------ILQFDPLGPPAERPKTGRPLQSRDDVDD--DAEMNPESLLP 856
            |.|       ....|||||..|||||.  .:.|.|.||  |.|:. :.|||
Mouse   777 YESSGNKEIDASYVDPLGPQIERPKTA--AKKRIDEDDFADEELG-DDLLP 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nompB	NP_724347.3	TPR_11	213..275	CDD:290150	34/61 (56%)
		TPR repeat	213..240	CDD:276809	16/26 (62%)
		TPR	216..244	CDD:197478	16/27 (59%)
		TPR repeat	245..279	CDD:276809	18/33 (55%)
		TPR repeat	284..309	CDD:276809	11/24 (46%)
		TPR repeat	479..502	CDD:276809	8/22 (36%)
		TPR repeat	509..539	CDD:276809	8/29 (28%)
		TPR_16	<529..568	CDD:290168	12/38 (32%)
		TPR repeat	544..568	CDD:276809	8/23 (35%)
		TPR_11	626..692	CDD:290150	28/65 (43%)
		TPR repeat	627..655	CDD:276809	11/27 (41%)
		TPR repeat	660..690	CDD:276809	12/29 (41%)
Ift88	NP_033402.2	TPR repeat	197..225	CDD:276809	11/27 (41%)
		TPR_11	199..260	CDD:290150	30/60 (50%)
		TPR_12	231..304	CDD:290160	38/72 (53%)
		TPR_1	238..265	CDD:278916	16/26 (62%)
		TPR repeat	238..261	CDD:276809	14/22 (64%)
		TPR repeat	271..301	CDD:276809	19/29 (66%)
		TPR repeat	305..333	CDD:276809	12/27 (44%)
		TPR repeat	420..444	CDD:276809	13/23 (57%)
		TPR	427..687	CDD:223533	92/283 (33%)
		TPR repeat	453..479	CDD:276809	8/30 (27%)
		TPR repeat	485..513	CDD:276809	6/27 (22%)
		SNAP	501..721	CDD:305195	80/238 (34%)
		TPR repeat	515..548	CDD:276937	11/34 (32%)
		TPR repeat	518..548	CDD:276809	11/31 (35%)
		TPR repeat	549..599	CDD:276937	19/62 (31%)
		TPR repeat	553..581	CDD:276809	9/40 (23%)
		TPR repeat	587..615	CDD:276809	11/27 (41%)
		TPR repeat	603..647	CDD:276937	18/43 (42%)
		TPR repeat	621..647	CDD:276809	10/25 (40%)
		TPR repeat	655..680	CDD:276809	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6167
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4761
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2008
Isobase	1	0.950	-	0	Normalized mean entropy	S3680
OMA	1	1.010	-	-		QHG56319
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007391
OrthoInspector	1	1.000	-	-		oto93148
orthoMCL	1	0.900	-	-		OOG6_103642
Panther	1	1.100	-	-	LDO	PTHR44117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6827
SonicParanoid	1	1.000	-	-		X5514
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.950