Protein Alignment Lamp1 and LAMP1

DIOPT Version :10

• Sequence 1: NP_610111.3
• Gene: Lamp1 / 35411
• FlyBaseID: FBgn0032949
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_005552.3
• Gene: LAMP1 / 3916
• HGNCID: 6499
• Length: 417
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 93/355 - (26%)
• Similarity: 146/355 - (41%)
• Gaps: 88/355 - (24%)

  Fly    13 LIMLFLLSSTVFSQKLIGLPRVGKNVSDLFLEQANPLTSSSSTISTSSTTTE------------- 64
            |.:.|..::|.:|.:|:...   .|:||..|..    .:||..|.|..:.|:
Human   100 LTLNFTRNATRYSVQLMSFV---YNLSDTHLFP----NASSKEIKTVESITDIRADIDKKYRCVS 157

  Fly    65 ------KPITTR----------STSTITPRSTTPSTESPS-TTAPVISTTIAPQPYPQ-PSIGAW 111
                  ..:|..          |.|:.:...|....:.|| ||||....:.:|.|.|: ||:..:
Human   158 GTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKY 222

  Fly   112 NTS-----CIMLQMAAQLNFTYEAREGNFTTGLYNIPSNASVEDAECKSQTTQFIHLIWGPETSK 171
            |.|     |::..|..|||.|||.::....|.|.||..|.:.....|.:      ||:.....|:
Human   223 NVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGA------HLVTLELHSE 281

  Fly   172 QSLIMYF----NKSNDTTVLSFMQIHLALLPEDFPDAKENQTVQLITRSDGAFKTPENM------ 226
            .:.::.|    |.|:....|..:|::..|     |||:           |.|||.....
Human   282 GTTVLLFQFGMNASSSRFFLQGIQLNTIL-----PDAR-----------DPAFKAANGSLRALQA 330

  Fly   227 ----SYHCTRVQKINMTETLDAEQLIGWISVSHVQVEAFRRANDTGFSVGHDCDSSETSDVVPIA 287
                ||.|...:.:.:|:...       :::..|.|:|| :.....|....:|...|.|.::|||
Human   331 TVGNSYKCNAEEHVRVTKAFS-------VNIFKVWVQAF-KVEGGQFGSVEECLLDENSMLIPIA 387

  Fly   288 VGIALAALILVVLISYLCARRRSTSRGYMS 317
            ||.|||.|:|:|||:||..|:||.: ||.:
Human   388 VGGALAGLVLIVLIAYLVGRKRSHA-GYQT 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lamp1	NP_610111.3	Lamp	106..262	CDD:480752	41/174 (24%)
LAMP1	NP_005552.3	First lumenal domain	29..194		18/100 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..221		12/36 (33%)
		Hinge	195..227		13/31 (42%)
		Lamp	221..365	CDD:460152	40/173 (23%)
		Second lumenal domain	228..382		41/183 (22%)
		TM_EGFR-like	381..411	CDD:213052	18/29 (62%)