DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lamp1 and Lamp1

DIOPT Version :9

Sequence 1:	NP_610111.3	Gene:	Lamp1 / 35411	FlyBaseID:	FBgn0032949	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_001304282.1	Gene:	Lamp1 / 16783	MGIID:	96745	Length:	407	Species:	Mus musculus

Alignment Length:	292	Identity:	80/292 - (27%)
Similarity:	130/292 - (44%)	Gaps:	54/292 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KNVSDLFLEQANPLTSSSSTISTSST--TTEKPITTRSTSTITPRSTTPSTESPSTTAPVISTTI 98
            |||:.:..:.......||...|...|  |.:.|              :|:|..||.:.|::.|
Mouse   159 KNVTVVLRDATIQAYLSSGNFSKEETHCTQDGP--------------SPTTGPPSPSPPLVPT-- 207

  Fly    99 APQPYPQPSIGAWNT-----SCIMLQMAAQLNFTYEAREGNFTTGLYNIPSNASVEDAECKSQTT 158
                  .|::..:|.     :|::..||.|||.||..::....|..:||..| ......|.
Mouse   208 ------NPTVSKYNVTGNNGTCLLASMALQLNITYLKKDNKTVTRAFNISPN-DTSSGSCG---- 261

  Fly   159 QFIHLI-WGPETSKQSLIMYF--NKSNDTTVLSFMQIHLALLPEDFPDAKENQTVQLITRSDGAF 220
              |:|: ...|...::|.:.|  |.|:....|..:::::.|     |||.. .|..:...|..|.
Mouse   262 --INLVTLKVENKNRALELQFGMNASSSLFFLQGVRLNMTL-----PDALV-PTFSISNHSLKAL 318

  Fly   221 KTPENMSYHCTRVQKINMTETLDAEQLIGWISVSHVQVEAFRRANDTGFSVGHDCDSSETSDVVP 285
            :.....||.|...:.|.:::.|.       ::|..|||:||:..:|...|| .:|.....:.::|
Mouse   319 QATVGNSYKCNTEEHIFVSKMLS-------LNVFSVQVQAFKVDSDRFGSV-EECVQDGNNMLIP 375

  Fly   286 IAVGIALAALILVVLISYLCARRRSTSRGYMS 317
            ||||.|||.|:|:|||:||..|:||.: ||.:
Mouse   376 IAVGGALAGLVLIVLIAYLIGRKRSHA-GYQT 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lamp1	NP_610111.3	Lamp	<77..318	CDD:279622	71/249 (29%)
Lamp1	NP_001304282.1	First lumenal domain	26..189		8/31 (26%)
		Lamp	107..407	CDD:279622	60/257 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..208		4/28 (14%)
		Hinge	190..219		5/28 (18%)
		Second lumenal domain	220..371		35/158 (22%)
		TM_EGFR-like	372..401	CDD:213052	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12375
eggNOG	1	0.900	-	-		E1_KOG4818
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I5206
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002671
OrthoInspector	1	1.000	-	-		otm44279
orthoMCL	1	0.900	-	-		OOG6_104018
Panther	1	1.100	-	-	O	PTHR11506
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4256
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850