DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv3 and atp1b1a

DIOPT Version :9

Sequence 1:	NP_001260675.1	Gene:	nrv3 / 35408	FlyBaseID:	FBgn0032946	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_571743.3	Gene:	atp1b1a / 64267	ZFINID:	ZDB-GENE-001127-3	Length:	306	Species:	Danio rerio

Alignment Length:	322	Identity:	96/322 - (29%)
Similarity:	150/322 - (46%)	Gaps:	61/322 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GFKKFLWNSETSQCLGRTGSSWAKILLFYIIFYAALTGFFAAIFTVFYQTLDNEKPKWMLDNGLI 85
            |:|.|:|||:..:.|||||.||.||.:||:|||..|.|.|.........||.|.||.:. |.
Zfish    10 GWKSFIWNSDKKEFLGRTGCSWLKIFIFYVIFYGCLAGIFIGTIQAMLLTLSNYKPTYQ-DR--- 70

  Fly    86 GSNPGLGFRPMPPEANVESTLVWYESSKKDNYKYWVDETSRFLKYHTYQDLEKQNQVNCSFEH-- 148
            .:.|||...|.|.:|.:.     |..:.:..|..:|:....|||.:. :|::|.   :..||.
Zfish    71 VAPPGLSHSPRPDKAEIN-----YNINDESTYLPYVNHIDAFLKAYN-EDVQKD---DTKFEECG 126

  Fly   149 -PPQ----------DD---KVCGIDFSSFSPCTAD-----NNFGYHVARPCIFLKLNKIYNWIPE 194
             .||          |:   |.|.........|:..     .|:|:...:||:.:|||:|.|::|.
Zfish   127 DKPQFYTDRGELESDNGVRKACRFRREWLGECSGQKDEKLKNYGFDDGQPCLIVKLNRIVNFMPR 191

  Fly   195 --IYNDSKTLPDHMPEELKQHIKEKQSLRPN-ETNVVWVSCEGENPADVENIKARDYYP-RMGFP 255
              ..|||      :||          ::||. :.||:.:.|..:...:...:....|:. ..|||
Zfish   192 PPASNDS------IPE----------AVRPKLQGNVIPIHCSSKREEEANLLGQIKYFGLGTGFP 240

  Fly   256 RYYFPF--KNIQ-GYIPPIVAVQF-TVETGVLINIECKAWARNINH---DRSDRRGSVHFEL 310
            ..|:|:  |.:| .|:.|:||::| .:.|.|.:.:|||.:..||::   |||..|..:.|.:
Zfish   241 LQYYPYYGKLLQPQYLQPLVAIKFYNITTDVDVRVECKVYGENIDYSEKDRSQGRFDIKFTI 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv3	NP_001260675.1	Na_K-ATPase	20..307	CDD:395224	95/317 (30%)
atp1b1a	NP_571743.3	Na_K-ATPase	8..303	CDD:298651	96/322 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5399
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37509
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4678
OMA	1	1.010	-	-		QHG45736
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm6361
orthoMCL	1	0.900	-	-		OOG6_104632
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4478
SonicParanoid	1	1.000	-	-		X254
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870