Protein Alignment nrv3 and ATP1B2

DIOPT Version :10

• Sequence 1: NP_001260675.1
• Gene: nrv3 / 35408
• FlyBaseID: FBgn0032946
• Length: 313
• Species: Drosophila melanogaster
• Sequence 2: NP_001669.3
• Gene: ATP1B2 / 482
• HGNCID: 805
• Length: 290
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 92/318 - (28%)
• Similarity: 141/318 - (44%)
• Gaps: 68/318 - (21%)

  Fly    20 EGFKKFLWNSETSQCLGRTGSSWAKILLFYIIFYAALTGFFAAIFTVFYQTLDNEKPKWMLDNGL 84
            |.:|:|:||..|.|.:||||:|||.|||||::||..||..|.....|..||:.:..||:  .:.|
Human    15 EEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKY--QDRL 77

  Fly    85 IGSNPGLGFRPMPPE----ANVESTLVWYESSKKDNYKYWVDETSRFLKYHTYQD-LEKQNQVNC 144
              :.|||..||....    .||..|..|.:..:|.|         :||:  .|.| ::.|....|
Human    78 --ATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLN---------KFLE--PYNDSIQAQKNDVC 129

  Fly   145 S----FEHPPQ-----DDKVCGIDFSSFSPCTA---DNNFGYHVARPCIFLKLNKIYNWIPEIYN 197
            .    :|.|..     ..:.|..:.:....|:.   ..::||...:||:|:|:|::.|:
Human   130 RPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKMNRVINF------ 188

  Fly   198 DSKTLPDHMPEELKQHIKEKQSLRPNETNVVWVSCEGENPADVENIKARDYYPRMG-FPRYYFPF 261
                           :....||:.        |:|.|:...|.||:.....:|..| ....|||:
Human   189 ---------------YAGANQSMN--------VTCAGKRDEDAENLGNFVMFPANGNIDLMYFPY 230

  Fly   262 ---KNIQGYIPPIVAVQF-TVETGVLINIECKAWARNI--NHDRSDRRGSVHFELMVD 313
               |....|..|:|||:| .|...|.:|:||:..|.||  :.:|....|.|.|:|.::
Human   231 YGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRIN 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nrv3	NP_001260675.1	Na_K-ATPase	18..307	CDD:459748	89/310 (29%)
ATP1B2	NP_001669.3	Na_K_ATPase_bet	2..289	CDD:273446	92/318 (29%)
		immunoglobulin-like	193..290		33/104 (32%)