DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv3 and nrv2

DIOPT Version :9

Sequence 1:	NP_001260675.1	Gene:	nrv3 / 35408	FlyBaseID:	FBgn0032946	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_001014475.1	Gene:	nrv2 / 33953	FlyBaseID:	FBgn0015777	Length:	323	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	156/310 - (50%)
Similarity:	209/310 - (67%)	Gaps:	4/310 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EYYAPPVKMGKWEGFKKFLWNSETSQCLGRTGSSWAKILLFYIIFYAALTGFFAAIFTVFYQTLD 72
            :||:.|.:..|.:..|:.:::||.:...||:..|||||.:||:.||..|....|.....|:||||
  Fly    14 QYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLD 78

  Fly    73 NEKPKWMLDNGLIGSNPGLGFRPMPPEANVESTLVWYESSKKDNYKYWVDETSRFLKYHTYQDL- 136
            ...|||.||..|||:||||||||:||..||||||:||:.::.:|||:|.|....||..:....|
  Fly    79 PRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLT 143

  Fly   137 --EKQNQVNCSFEHPPQDDKVCGIDFSSFSPCTADNNFGYHVARPCIFLKLNKIYNWIPEIYNDS 199
              ..||..||.:..||...:||.:|..::||||.:||:.||.:.|||||||||||.||||.||.|
  Fly   144 PGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRS 208

  Fly   200 KTLPDHMPEELKQHIKEKQSLRPNETNVVWVSCEGENPADVENIKARDYYPRMGFPRYYFPFKNI 264
            ..||.:||..||.:|.|.:..:|.:.|.:|||||||||||.|||.|.:|.|..|||.|::|::|.
  Fly   209 NDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNS 273

  Fly   265 QGYIPPIVAVQF-TVETGVLINIECKAWARNINHDRSDRRGSVHFELMVD 313
            :||:.|:|||.| ..:.|::||:||:||||||.|||.:|.||||:||::|
  Fly   274 EGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv3	NP_001260675.1	Na_K-ATPase	20..307	CDD:395224	147/290 (51%)
nrv2	NP_001014475.1	Na_K-ATPase	24..317	CDD:278704	148/292 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473142
Domainoid	1	1.000	125	1.000	Domainoid score	I5399
eggNOG	1	0.900	-	-		E1_KOG3927
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4678
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40668at7147
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm6361
orthoMCL	1	0.900	-	-		OOG6_104632
Panther	1	1.100	-	-	P	PTHR11523
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X254
	11	10.800