DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv3 and Atp1b3

DIOPT Version :9

Sequence 1:	NP_001260675.1	Gene:	nrv3 / 35408	FlyBaseID:	FBgn0032946	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_037045.1	Gene:	Atp1b3 / 25390	RGDID:	2172	Length:	279	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	98/318 - (30%)
Similarity:	147/318 - (46%)	Gaps:	76/318 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MGKWEGFKKFLWNSETSQCLGRTGSSWAKILLFYIIFYAALTGFFAAIFT----VFYQTLDNEKP 76
            :.:|   |.|::|..:.:.||||..||..|||||::||    ||.||:||    |..|||::|.|
  Rat    13 LAEW---KLFIYNPTSGEFLGRTSKSWGLILLFYLVFY----GFLAALFTFTMWVMLQTLNDEVP 70

  Fly    77 KWMLDNGLIGSNPGLGFRPMPPEANVESTLVWYESSKKDNYKYWVDETSRFLKYHTYQDLEKQNQ 141
            |:   ...|.| |||...|.||.| ::.|   |..|....||.:|::...|||.::.:  |::|.
  Rat    71 KY---RDQIPS-PGLMVFPKPPTA-LDYT---YSMSDPHTYKKFVEDLKNFLKPYSVE--EQKNL 125

  Fly   142 VNCS----FEHPPQDDKVCGIDFSSFSPCTA--DNNFGYHVARPCIFLKLNKIYNWIPEIYNDSK 200
            .:|.    |.....|...|....|....|:.  |:||||...:||:.:|:|:|.          :
  Rat   126 TDCPGGALFHQEGPDYSACQFPVSLLQECSGVNDSNFGYSKGQPCVLVKMNRII----------E 180

  Fly   201 TLPDHMPEELKQHIKEKQSLRPNETNVVWVSC--EGENPADVENIKARDYYPRMG-FPRYYFPF- 261
            .:||..|                     :::|  :.||.|::..      ||..| ....|||:
  Rat   181 LVPDGAP---------------------YITCITKEENIANIVT------YPDDGLIDLKYFPYY 218

  Fly   262 --KNIQGYIPPIVAVQ--FTVE-TGVLINIECKA-WARNI--NHDRSDRRGSVHFELM 311
              |...||..|:||||  |..: |...:.|||:. ..||:  .::|....|.|.|:::
  Rat   219 GKKRHVGYRQPLVAVQVIFGADATKKEVTIECQIDGTRNLKNKNERDKFLGRVSFKVI 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv3	NP_001260675.1	Na_K-ATPase	20..307	CDD:395224	95/308 (31%)
Atp1b3	NP_037045.1	Na_K_ATPase_bet	1..279	CDD:273446	98/318 (31%)
Atp1b3	NP_037045.1	immunoglobulin-like. /evidence=ECO:0000250	186..279		30/118 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45736
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm9102
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.930