DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrv3 and Atp1b2

DIOPT Version :9

Sequence 1:	NP_001260675.1	Gene:	nrv3 / 35408	FlyBaseID:	FBgn0032946	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_036639.2	Gene:	Atp1b2 / 24214	RGDID:	2171	Length:	290	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	91/318 - (28%)
Similarity:	141/318 - (44%)	Gaps:	68/318 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EGFKKFLWNSETSQCLGRTGSSWAKILLFYIIFYAALTGFFAAIFTVFYQTLDNEKPKWMLDNGL 84
            |.:|:|:||..|.|.:||||:|||.|||||::||..||..|.....|..||:.:..||:  .:.|
  Rat    15 EEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSDHTPKY--QDRL 77

  Fly    85 IGSNPGLGFRPMPPE----ANVESTLVWYESSKKDNYKYWVDETSRFLKYHTYQD-LEKQNQVNC 144
              :.|||..||....    .|:..|..|.:..:|.|         :||:  .|.| ::.|....|
  Rat    78 --ATPGLMIRPKTENLDVIVNISDTESWDQHVQKLN---------KFLE--PYNDSIQAQKNDVC 129

  Fly   145 S----FEHPPQ-----DDKVCGIDFSSFSPCTA---DNNFGYHVARPCIFLKLNKIYNWIPEIYN 197
            .    :|.|..     ..:.|..:.:....|:.   ..::||...:||:|:|:|::.|:
  Rat   130 RPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDPTHYGYSTGQPCVFIKMNRVINF------ 188

  Fly   198 DSKTLPDHMPEELKQHIKEKQSLRPNETNVVWVSCEGENPADVENIKARDYYPRMG-FPRYYFPF 261
                           :....||:.        |:|.|:...|.||:.....:|..| ....|||:
  Rat   189 ---------------YAGANQSMN--------VTCVGKKDEDAENLGHFIMFPANGNIDLMYFPY 230

  Fly   262 ---KNIQGYIPPIVAVQF-TVETGVLINIECKAWARNI--NHDRSDRRGSVHFELMVD 313
               |....|..|:|||:| .|...|.:|:||:..|.||  :.:|....|.|.|:|.::
  Rat   231 YGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRIN 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrv3	NP_001260675.1	Na_K-ATPase	20..307	CDD:395224	88/310 (28%)
Atp1b2	NP_036639.2	Na_K_ATPase_bet	2..289	CDD:273446	91/318 (29%)
Atp1b2	NP_036639.2	immunoglobulin-like. /evidence=ECO:0000250	193..290		33/104 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4756
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4445
OMA	1	1.010	-	-		QHG45736
OrthoDB	1	1.010	-	-		D422722at33208
OrthoFinder	1	1.000	-	-		FOG0000357
OrthoInspector	1	1.000	-	-		mtm9102
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11523
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X254
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980