Protein Alignment CG8665 and ALDH1A2

DIOPT Version :10

• Sequence 1: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_003879.2
• Gene: ALDH1A2 / 8854
• HGNCID: 15472
• Length: 518
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 233/482 - (48%)
• Similarity: 324/482 - (67%)
• Gaps: 9/482 - (1%)

  Fly   433 TQLFINGEFVDAEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHSAF-YGS-WRQITPRQR 495
            |::|||.|:.::|:.|...:.||...|.:|:|..|...|:||||:||..|| .|| ||::...:|
Human    38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASER 102

  Fly   496 GQLMLNLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVNPA 560
            |:|:..||||:||::..|||:||::.|..:..|....:...|:.:||:|||.|||.|.||||:
Human   103 GRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVD-- 165

  Fly   561 RPNNVLTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELTVR 625
              .:..||||.|||||||.|.|||:||:|.:||:|..:..|||.:||||:..||:||....|...
Human   166 --GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE 228

  Fly   626 AGFPPGVINVLPGKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPL 690
            |||||||||:|||.|..||.|:|.|..:.|:.|||||.:||.|.::...||||:.:||||||||.
Human   229 AGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPN 293

  Fly   691 IIFADCDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPLDRSTA 755
            |||||.|:|.||:.....||||:|:.|.|..|:|||:.|::||:||.::..:...:|.|.|.:|.
Human   294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTE 358

  Fly   756 HGPQNHKAHFDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESFGPI 820
            .|||..|..::|:||..:.||.|||||..|| :....||:|..||||:||||||.||:||.|||:
Human   359 QGPQIDKKQYNKILELIQSGVAEGAKLECGG-KGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPV 422

  Fly   821 MIISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTVFVNVYNKTDVAAPFGG 885
            ..|.:|  ..:|.:::|||.:::||.:.|||.||.|||..:..::||||::|.||..:..:||||
Human   423 QEILRF--KTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGG 485

  Fly   886 FKQSGYGKDLGQEALNEYLKTKCVTVE 912
            ||.||.|:::|:..|.||.:.|.|||:
Human   486 FKMSGNGREMGEFGLREYSEVKTVTVK 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	336..394	CDD:425746
		ALDH_F1L_FTFDH	428..913	CDD:143458	233/482 (48%)
ALDH1A2	NP_003879.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	232/480 (48%)