Protein Alignment CG8665 and aldh1a2

DIOPT Version :10

• Sequence 1: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001039196.1
• Gene: aldh1a2 / 734052
• XenbaseID: XB-GENE-1012909
• Length: 511
• Species: Xenopus tropicalis
• Alignment Length: 557
• Identity: 110/557 - (19%)
• Similarity: 187/557 - (33%)
• Gaps: 170/557 - (30%)

  Fly   305 IMVLDTLVGQTQWFGYGSRIIVVTND------KHFLIA--HGIDHIYEVSFPTDVHACQMLCQS- 360
            :||...||.    ||..::::|...:      ||..:.  .|.|.        |.::|.:..|.
 Frog    74 VMVTTQLVR----FGLSNQLVVAFKEDNTVAFKHLFLKGYSGTDE--------DDYSCSVYTQED 126

  Fly   361 -------AFKQNYAPKGFEDLVVDVVRHAGNFP--LGLNLLGKYLRRRDMEYWMDMLPRLENSLR 416
                   |..|.:..|   |:.:..:.:..|..  :||.:..::.::.      .|.|..| :|.
 Frog   127 AYESIFFAINQYHQLK---DITLGTLGYGENEDNRIGLKVCKQHYKKG------TMFPSNE-TLN 181

  Fly   417 IDGKIE-----------------------------KILRISYD----GL--------ESEDQEIF 440
            ||..:|                             ::|::...    |:        |..|..:|
 Frog   182 IDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVF 246

  Fly   441 RHIACLFNHMEVTTIKSLLADSDVSFALENLADKSLIHVRQ---GYVVMH---------RSLQEM 493
            ::.....|......|| :..|||..  :|...|.::....|   .||::.         .||...
 Frog   247 QNTIIFDNKAHSGKIK-IYFDSDAK--IEECKDLNIFGSTQKNAQYVLVFDAFVIVICLASLILC 308

  Fly   494 GRKIVRIQSIDKPGEREFL------VDPNDIHDILNACTGTQKVLGISLDIRNIRELDVHERAFK 552
            .|.||....:.|.....||      |...|..:.:|.    ..||.|..|:..|
 Frog   309 TRSIVLALRLRKRFLNFFLEKYKRPVCDTDQWEFING----WYVLVIISDLMTI----------- 358

  Fly   553 GMSNLRFLEIKNFGLKEDGLHLPPSFDYLP---RTLKLLCWSKFPMRCMPFGFRPENLVKLEMQY 614
             :.::..:|||...|        .::|...   .|..||.|... :|.:.: |:..|::.|.||
 Frog   359 -IGSILKMEIKAKNL--------TNYDLCSIFLGTSTLLVWVGV-IRYLGY-FQAYNVLILTMQ- 411

  Fly   615 SKLHKLWEGVAPLTCLKEMDLHGSSNLKVIPDLSEATNLEILNLKFCESLVELP--SSIRNLN-- 675
                                    ::|..:........:..|...||..:|..|  ....|||
 Frog   412 ------------------------ASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFENLNTV 452

  Fly   676 -----KLLNLDMLNCKSLKILPTGFNLKSLDRLNLYHCSKLKTFPKFSTNISVLNLNLTNIEDFP 735
                 .|:|.|.:.....:|......:....||.||....|..:...|..|:::..:...|:.|.
 Frog   453 AECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQ 517

  Fly   736 SNLHLE-NLVEFRISKEESDEKQWEEEKVSSSTLNII 771
            .|...| :|.||  .||.|.::::::|  ||:.|:.|
 Frog   518 QNGFPETDLQEF--LKECSSKEEYQKE--SSAFLSCI 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731	4/10 (40%)
		PP-binding	336..394	CDD:425746	12/69 (17%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	81/387 (21%)
aldh1a2	NP_001039196.1	ALDH_F1AB_F2_RALDH1	25..505	CDD:143459	95/506 (19%)