Protein Alignment CG8665 and aldh8a1

DIOPT Version :10

• Sequence 1: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001004540.1
• Gene: aldh8a1 / 447801
• ZFINID: ZDB-GENE-040912-3
• Length: 487
• Species: Danio rerio
• Alignment Length: 484
• Identity: 175/484 - (36%)
• Similarity: 272/484 - (56%)
• Gaps: 15/484 - (3%)

  Fly   436 FINGEFVDAEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHSAFYGSWRQITPRQRGQLML 500
            :|.|:||  ...:.::..:|:..||.|||..:.|.:|:.|||||..|| ..|...:|..|.:::.
Zfish    13 YIGGKFV--PCSKLIDSFDPSTGEVYCKVPDSGAEEVNAAVRAAKEAF-PDWSAKSPADRSKVLN 74

  Fly   501 NLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVNPARPNNV 565
            .||||:|...||....||.|.|...|.|....:..|...:|:||   ..:..:|...:.......
Zfish    75 KLADLIEARLEEFVQAESKDQGKTITFARNVDIPRSAYNFRFFA---SSVLHHTNDCSQMDHMGC 136

  Fly   566 LTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELTVRAGFPP 630
            |.:|.:.|:||.|||:|||.||.:|:||:|..:|.|||.:.||::...:||....:|...|||||
Zfish   137 LNYTIRCPVGVAGLISPWNLPLYLLTWKIAPAVATGNTVVAKPSEMTSVTAWMMCQLLEEAGFPP 201

  Fly   631 GVINVLPGKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPLIIFAD 695
            ||:|::.|.|..||.|:..|..|..:.|||||...:.|.:..| .:.||.|||||||:|.|||||
Zfish   202 GVVNIVFGTGPRAGDALVSHPDVPLISFTGSTATARLITERSA-PHCKKLSLELGGKNPAIIFAD 265

  Fly   696 CDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPLDRSTAHGPQN 760
            .||::.:...:.|.|.|:||.|:...|:|||..::.||:.|.::..|....|.|.|.|..:|...
Zfish   266 ADMEQCISTTVRSSFSNQGEICLCTSRIFVERSVYPEFLTRFVEATRRWKTGVPSDPSNDNGALI 330

  Fly   761 HKAHFDKLLEFCRRGVDEGAKLVYG----GCRVP--NLKGYFFTPTVFTNVTDDMFIAQEESFGP 819
            .|.|..|:..:....:.|||::..|    ...:|  |:.|||..||:.:.|.|...:.|||.|||
Zfish   331 SKEHLQKVKGYITLALAEGAQVHCGEGVDKLALPQQNIGGYFMLPTIISGVKDSSALMQEEIFGP 395

  Fly   820 IMIISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTVFVNVYNKTDVAAPFG 884
            :..::.|:  :.:.::.|||...|||::.|:::|:|:....|.:::||.|:.|.:...|:..|||
Zfish   396 VTCVTPFD--EEEEVISRANNVRYGLSATVWSRDVGRVHRVARKLQAGLVWTNCWLVRDLNLPFG 458

  Fly   885 GFKQSGYGKDLGQEALNEYLKTKCVTVEY 913
            |.|.||.|::.|:::.:.:.:.|.|||::
Zfish   459 GMKHSGIGREGGKDSYHFFTEVKSVTVKH 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	336..394	CDD:425746
		ALDH_F1L_FTFDH	428..913	CDD:143458	175/482 (36%)
aldh8a1	NP_001004540.1	ALDH_F8_HMSADH	27..485	CDD:143412	169/464 (36%)