Protein Alignment CG8665 and ALDH1B1

DIOPT Version :10

• Sequence 1: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_011516104.2
• Gene: ALDH1B1 / 219
• HGNCID: 407
• Length: 564
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 240/563 - (42%)
• Similarity: 338/563 - (60%)
• Gaps: 42/563 - (7%)

  Fly   353 STDFFASGAGSMDVVRLVEEVKEAFDVPLQNEQVFMAPVFEEFFSLLVRFLRQGSAGFGNQQLDF 417
            ||..:.|...|:.::|                  |:||   ...||..|..|..||.
Human    35 STSAYQSVTSSVSMLR------------------FLAP---RLLSLQGRTARYSSAA-------- 70

  Fly   418 EAFTLKANKREIRVP-TQLFINGEFVDAEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHS 481
               .|.:......:| .|||||.|:.||.:::|...||||..||:..||.....|||:||:||..
Human    71 ---ALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAARE 132

  Fly   482 AF-YGS-WRQITPRQRGQLMLNLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFA 544
            || .|| ||::...:||:|:..||||:||::..||::|::|:|..:..:....:...|:.:||||
Human   133 AFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFA 197

  Fly   545 GWCDKIQGNTIPVNPARPNNVLTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPA 609
            ||.||..|.|||::    .....|||.||:||||.|.|||:||:|..||:|..:|.|||.::|.|
Human   198 GWADKWHGKTIPMD----GQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVA 258

  Fly   610 QTCPLTALKFAELTVRAGFPPGVINVLPGKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSCAD 674
            :..||:||..|.|...|||||||:|::.|.|..||.|:|.|..|.|:.|||||.:|..|.|:..|
Human   259 EQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGD 323

  Fly   675 SNLKKCSLELGGKSPLIIFADCDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLK 739
            ||||:.:||||||||.|:.||.||:.||:....::|||.|:.|.|..|.|||:.|::||:.|.::
Human   324 SNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVE 388

  Fly   740 DLRTMTIGDPLDRSTAHGPQNHKAHFDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTVFTN 804
            ..:...:|:|.:..|..|||..|..|:::|.:.:.|..|||||:.||.|... :|:|..||||..
Human   389 KAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGE-RGFFIKPTVFGG 452

  Fly   805 VTDDMFIAQEESFGPIMIISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTV 869
            |.|||.||:||.|||:..:.||  ..|:.:::|||.|.||||:.|||:|:.||:.|...::||||
Human   453 VQDDMRIAKEEIFGPVQPLFKF--KKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTV 515

  Fly   870 FVNVYNKTDVAAPFGGFKQSGYGKDLGQEALNEYLKTKCVTVE 912
            :||.||......||||||:||.|::||::.|..|.:.|.||::
Human   516 WVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	336..394	CDD:425746	8/40 (20%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	225/488 (46%)
ALDH1B1	XP_011516104.2	ALDH_F1AB_F2_RALDH1	78..558	CDD:143459	225/486 (46%)