Protein Alignment CG8665 and Aldh4a1

DIOPT Version :10

• Sequence 1: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_780647.3
• Gene: Aldh4a1 / 212647
• MGIID: 2443883
• Length: 562
• Species: Mus musculus
• Alignment Length: 588
• Identity: 134/588 - (22%)
• Similarity: 226/588 - (38%)
• Gaps: 98/588 - (16%)

  Fly   333 VKRSLLAGIWKAILKEDVESSTDFFASGAGSMDVVRLVEEVKEAFDVPLQNEQVFMAPVFEEFFS 397
            ::||||:..|:                |||.        ..|....:.:.||.:.   .|.:
Mouse     7 LRRSLLSHAWR----------------GAGL--------RWKHTSSLKVTNEPIL---AFSQ--- 41

  Fly   398 LLVRFLRQGSAGFGNQQLDFEAFTLKANKREIRVPTQLFINGEFVDAEAQRTLEIVNPTNEEVLC 462
                         |:.:.|.....||..|.::.....:..:.|...::.|..|...|..::  :.
Mouse    42 -------------GSPERDALQKALKDLKGQMEAIPCVVGDEEVWTSDIQYQLSPFNHAHK--VA 91

  Fly   463 KVACASATDVDKAVRAAHSAFYGSWRQITPRQRGQLMLNLADLME--RNKEELATIESVDSGAVY 525
            |...|....:::|:.||.:| ...|.......|.|:.|..||::.  |..|.||
Mouse    92 KFCYADKALLNRAIDAALAA-RKEWDLKPMADRAQVFLKAADMLSGPRRAEVLA----------- 144

  Fly   526 TLALKTHVGMS--------------IEAWRYFAGWCDKIQGNTIPVNPARPNNVLTFTRKEPIGV 576
                ||.||..              |:.:|:.|.:..:::|.. |::.....|...:...|  |.
Mouse   145 ----KTMVGQGKTVIQAEIDAAAELIDFFRFNAKFAVELEGEQ-PISVPPSTNHTVYRGLE--GF 202

  Fly   577 CGLITPWNYPLMMLSWKMAACIA-AGNTCLIKPAQTCPLTALKFAELTVRAGFPPGVINVLPGKG 640
            ...|:|:|:  ..:...:|...| .||..|.||:.|..|.:.....:...||.||.:|..:|..|
Mouse   203 VAAISPFNF--TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADG 265

  Fly   641 SDAGQAVADHELVRKLGFTGSTPIGKHIMKSCADS-----NLKKCSLELGGKSPLIIFADCDMDK 700
            ...|..|...|.:..:.||||.|..||:.:..|.:     ...:.:.|.|||:...:.:..|:|.
Mouse   266 PTFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDS 330

  Fly   701 AVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPL-DRSTAHGPQNHKAH 764
            .|...:.|.|...|:.|.|..||:|...:..:...|:|::...:.:|||. |..|..........
Mouse   331 VVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKA 395

  Fly   765 FDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESFGPIMIISKFNGS 829
            |.::.::........:..:..|.:.....||:..|.:..:......|.:||.|||::.:..:...
Mouse   396 FARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDD 460

  Fly   830 DIDSLMQRA-NRTEYGLASGVFTKDIGKAL-NFADRI---EAGTVFVNVYNKTDVAA--PFGGFK 887
            .....:|.. :.|.|||...||.:|  ||: ..|.|:   .||..::|..:...|..  ||||.:
Mouse   461 KYRETLQLVDSTTSYGLTGAVFAQD--KAIVQEATRMLRNAAGNFYINDKSTGSVVGQQPFGGAR 523

  Fly   888 QSG 890
            .||
Mouse   524 ASG 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	336..394	CDD:425746	11/57 (19%)
		ALDH_F1L_FTFDH	428..913	CDD:143458	117/493 (24%)
Aldh4a1	NP_780647.3	ALDH_F4-17_P5CDH	31..552	CDD:143441	125/540 (23%)