Protein Alignment CG8665 and Aldh2

DIOPT Version :10

• Sequence 1: NP_610107.1
• Gene: CG8665 / 35407
• FlyBaseID: FBgn0032945
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_033786.1
• Gene: Aldh2 / 11669
• MGIID: 99600
• Length: 519
• Species: Mus musculus
• Alignment Length: 481
• Identity: 221/481 - (45%)
• Similarity: 318/481 - (66%)
• Gaps: 9/481 - (1%)

  Fly   434 QLFINGEFVDAEAQRTLEIVNPTNEEVLCKVACASATDVDKAVRAAHSAF-YGS-WRQITPRQRG 496
            |:|||.|:.||.:::|...|||:..||:|:||..:..||||||:||.:|| .|| ||::....||
Mouse    40 QIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRG 104

  Fly   497 QLMLNLADLMERNKEELATIESVDSGAVYTLALKTHVGMSIEAWRYFAGWCDKIQGNTIPVNPAR 561
            :|:..||||:||::..||.:|::|:|..|.::....:.|.::..||:|||.||..|.|||::
Mouse   105 RLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPID--- 166

  Fly   562 PNNVLTFTRKEPIGVCGLITPWNYPLMMLSWKMAACIAAGNTCLIKPAQTCPLTALKFAELTVRA 626
             .:..::||.||:||||.|.|||:||:|.:||:...:|.||..::|.|:..|||||..|.|...|
Mouse   167 -GDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEA 230

  Fly   627 GFPPGVINVLPGKGSDAGQAVADHELVRKLGFTGSTPIGKHIMKSCADSNLKKCSLELGGKSPLI 691
            ||||||:|::||.|..||.|:|.||.|.|:.|||||.:|..|..:...||||:.:||||||||.|
Mouse   231 GFPPGVVNIVPGFGPTAGAAIASHEGVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNI 295

  Fly   692 IFADCDMDKAVKHGMSSVFFNKGENCIAAGRLFVEDRIHDEFIRRVLKDLRTMTIGDPLDRSTAH 756
            |.:|.|||.||:....::|||:|:.|.|..|.||::.::|||:.|.:...::..:|:|.|..|..
Mouse   296 IMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQ 360

  Fly   757 GPQNHKAHFDKLLEFCRRGVDEGAKLVYGGCRVPNLKGYFFTPTVFTNVTDDMFIAQEESFGPIM 821
            |||..:..|.|:|.:.:.|..|||||:.||....: :|||..||||.:|.|.|.||:||.|||:|
Mouse   361 GPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAAD-RGYFIQPTVFGDVKDGMTIAKEEIFGPVM 424

  Fly   822 IISKFNGSDIDSLMQRANRTEYGLASGVFTKDIGKALNFADRIEAGTVFVNVYNKTDVAAPFGGF 886
            .|.||  ..|:.::.|||.::||||:.|||||:.||...:..::||||::|.|:.....:||||:
Mouse   425 QILKF--KTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGY 487

  Fly   887 KQSGYGKDLGQEALNEYLKTKCVTVE 912
            |.||.|::||:..|..|.:.|.|||:
Mouse   488 KMSGSGRELGEYGLQAYTEVKTVTVK 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8665	NP_610107.1	FMT_core	5..207	CDD:444886
		FDH_Hydrolase_C	212..316	CDD:187731
		PP-binding	336..394	CDD:425746
		ALDH_F1L_FTFDH	428..913	CDD:143458	221/481 (46%)
Aldh2	NP_033786.1	SIFI-degron. /evidence=ECO:0000250|UniProtKB:P05091	12..26
		ALDH_F1AB_F2_RALDH1	33..513	CDD:143459	220/479 (46%)