Protein Alignment Tsp39D and TSPAN8

DIOPT Version :10

• Sequence 1: NP_523612.3
• Gene: Tsp39D / 35405
• FlyBaseID: FBgn0032943
• Length: 235
• Species: Drosophila melanogaster
• Sequence 2: NP_004607.1
• Gene: TSPAN8 / 7103
• HGNCID: 11855
• Length: 237
• Species: Homo sapiens
• Alignment Length: 235
• Identity: 69/235 - (29%)
• Similarity: 122/235 - (51%)
• Gaps: 17/235 - (7%)

  Fly     3 SGGLTCVKYLTFFCNLLFALTGLLIFLVGGMVQLNYAHYSNFVSDHV----WTAPIILMIVGAAV 63
            :|...|:||..|..|.||.|.|:||..:...|:::....:.|.|:.|    :.|..||:.|||.:
Human     2 AGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAII 66

  Fly    64 AVICFLGCCGALKESSCMILSFALLAVVIFLFEIGLGLAGYVKHTGLHQIM-ESQFNST---MQH 124
            .::.|||||||:|||.||:|.|.:..::|.|.::..|:.|.|..:...:|: |:.:.:|   ...
Human    67 MILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSAT 131

  Fly   125 YKERADYRDAWTLLQTELDCCG-INGPNDWETVYRNSTLPAACCSVINLSEAKECTNTHATQ--- 185
            .:....:::|..:.|.|..||| :||..||...:::.....||     |.:.:.|.:.:..|
Human   132 GESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCAC-----LDKQRPCQSYNGKQVYK 191

  Fly   186 HGCLQKLLEILDSKTLILASVVLGVAGIQMLTILFACCLY 225
            ..|:..:.:.|....:|:..:..|:|.|::|.::|:..||
Human   192 ETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLY 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp39D	NP_523612.3	Tetraspanin	9..226	CDD:459767	67/229 (29%)
		tetraspanin_LEL	131..>167	CDD:351888	11/36 (31%)
TSPAN8	NP_004607.1	Tetraspanin	8..232	CDD:459767	67/229 (29%)
		hydrophobic region	10..33		9/22 (41%)
		hydrophobic region	58..78		11/19 (58%)
		hydrophobic region	83..109		8/25 (32%)
		TM4SF3_like_LEL	106..206	CDD:239407	22/104 (21%)
		hydrophobic region	206..232		8/26 (31%)